Anterior Cruciate Ligament Injury
Conditions
Keywords
preemptive analgesia, cruciate ligament
Brief summary
The aims of this study was to compare analgesic efficacy of preoperative administration of etoricoxib versus celecoxib for post-operative pain relief after arthroscopic anterior cruciate ligament reconstruction. One hundred and two patients diagnosed as anterior cruciate ligament injury will randomized into 3 groups using opaque envelope. Both patients and surgeon were blinded to the allocation. All of the patients will be operated by one orthopaedic surgeon under regional anesthesia. Each group will be given either etoricoxib 120 mg., celecoxib 400 mg., or placebo 1 hour prior to operative incision. Post-operative pain intensity, time to first dose of analgesic requirement and numbers of analgesic used for rescue pain control and adverse events will be recorded periodically to 48 hours after surgery.
Interventions
DRUGCelecoxib
celecoxib 400 mg 1 cap before surgery
DRUGetoricoxib
120 mg 1 tab before surgery
Sponsors
Prince of Songkla University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
15 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* patients with anterior cruciate ligament injury age 15-50 yr
Exclusion criteria
* previous knee surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score | 6,12,24,48 hour postoperative |
Secondary
| Measure | Time frame |
|---|---|
| number of analgesic used | 48 hour postoperative |
Countries
Thailand
Outcome results
None listed