Cancer of the Head and Neck
Conditions
Brief summary
Solid tumours contain varying degrees of hypoxia. Studies show hypoxia to be associated with poor local control and survival, as hypoxia is a cause of resistance to radio- and chemotherapy and the development of a more aggressive tumour. Previous attempts to measure hypoxia have been biased because the techniques have been invasive, not repeatable or difficult to apply on a routine basis. There is great interest in trying to measure hypoxia in tumours as this could lead to individualized hypoxia-modifying therapy and prediction of treatment response. Additionally the investigators' knowledge of change in hypoxia over time is limited, but of great interest as individualised treatment, such as intensity-modulated radiation therapy (IMRT) is emerging. 18F-FAZA, appears promising. It is a nitroimidazole, which gets trapped in hypoxic cells and can be detected by a positron emission therapy (PET) scan. Compared to other nitroimidazoles, 18F-FAZA has superior biokinetics and thereby is believed to provide a faster and clearer image of hypoxia. The investigators' hypothesis is that 18F-FAZA can be used as a prognostic marker in HNSCC.
Interventions
OTHER18F-FAZA
PET scan
Sponsors
Danish Head and Neck Cancer Group
University of Aarhus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Histological proven squamous cell carcinoma of the pharynx, larynx, oropharynx and hypopharynx * Curative intent and no prior treatment * Age \>= 18 years * stage T1-4 N0-N3 M0. * Informed consent according to local guidelines and national law * The patient is able (psychological, sociological, geographical and physical) to carry through the treatment and follow-up * Fertile women must use contraceptive devices (IUD or oral contraceptives)
Exclusion criteria
* No serious concurrent medical disease * No metastasis * No prior disease that can affect the treatment, evaluation or outcome of current disease * No pregnant or breastfeeding woman
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Can 18F-FAZA can be used as a prognostic marker in HNSCC? | 1, 5 years |
Secondary
| Measure | Time frame |
|---|---|
| Determine the changes in hypoxia in solid tumours as assessed by 18F-FAZA PET during radiotherapy | Patients will be scanned prior to treatment, every 2 weeks during their treatment and once following radiation |
Countries
Denmark
Outcome results
None listed