Labor Pain
Conditions
Keywords
Oxycodone, Labour pain, Pregnancy, Pregnant women
Brief summary
Childbirth is one of the most painful events that a woman is likely to experience, and thus is a major concern for most parturient. Severe pain releases stress mediators and may thus compromise fetus well-being if placental perfusion is decreased. Epidural analgesia is the golden standard for the management of severe labor pain. However, it could not always be used both due the parturient related factors and the organizational reasons.However, the knowledge on safety and efficacy of oxycodone involving mother, fetus and newborn is limited. Aim of the study is firstly, to evaluate the efficacy and safety of oxycodone in labor pain healthy parturients. Secondly, to measure parturient's blood oxycodone concentration during labour and fetal concentration from placental umbilical vein and artery right after birth.
Interventions
DRUGOxycodone
Intravenous, 1 mg, 5 times, in every 5 minutes, duration of drug administration 25 minutes
Sponsors
Kuopio University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Labouring healthy women * Early labour * Age 18-45 years
Exclusion criteria
* Sleep apnea or other central deficit affecting breathing * Pulmonary insufficiency * Liver of kidney insufficiency * Use of mono amine oxidase medication * Thyroid, pituitary insufficiency * Paralytic ileus * Other contraindication specified by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The efficacy and safety of oxycodone in labor pain | 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| The parturient's blood oxycodone concentration during labour and fetal concentration from placental umbilical vein and artery right after birth | 24 hours |
Countries
Finland
Outcome results
None listed