Schizophrenia or Schizoaffective Disorder
Conditions
Keywords
Schizophrenia, predictors of response, antipsychotics, 18-45 years old, non-refractory
Brief summary
The objective of this study is to evaluate predictors of response to antipsychotic medication in subjects with schizophrenia. The investigators will evaluate psychopathology,brain MRI, genetics and neuropsychological profile. Two groups of treatment will be compared: first generation antipsychotics vs. second generation antipsychotics. Participants will be randomized to one of the groups. Trial duration: 12 weeks.
Interventions
DRUGAntipsychotics
Quetiapine 25-800 mg; ziprasidone 80-160 mg; olanzapine 5-20mg; risperidone 2-8 mg; aripiprazole 15-30 mg
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Schizophrenia or schizoaffective disorder * Age: 18-45 years olde * Less than 10 years of diagnosis * Acute exacerbation of psychotic symptoms
Exclusion criteria
* Use of clozapine * Clinical unstable disease * Delirium and cognitive disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| % responders to first generation antipsychotics vs. % responders to second generation antipsychotics | 8-12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| % of treatment abandon and respective causes | 8-12 weeks |
Countries
Brazil
Contacts
Primary ContactMonica Kayo, MD
Backup ContactHelio Elkis, PhD
Outcome results
None listed