Role of Oral Glutathione in Skin Whitening

Glutathione as an Oral Whitening Agent: a Randomized, Double-blind, Placebo-controlled Study

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01016080

Enrollment

Registered

2009-11-18

Start date

2009-02-28

Completion date

2009-06-30

Last updated

2009-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin Whitening

Keywords

glutathione, melanin, whitening, UV spots, skin pigment

Brief summary

Oral and intravenous glutathione have been used widely to whiten the skin. The investigators tested this hypothesis by giving oral glutathione for 4 weeks to medical students.

Interventions

DRUGglutathione

250 mg capsules, twice daily, orally

DRUGplacebo

250 mg capsules, twice daily, orally

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 25 Years

Inclusion criteria

* Healthy medical students

Exclusion criteria

* history of skin cancer, especially melanoma * consumption of any preparations containing glutathione within 1 month of enrollment * pigmentary disorders or any dermatoses

Design outcomes

Primary

Measure	Time frame
Skin melanin index	4 weeks

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026