Cementless One-stage Revision of the Chronic Infected Hip Arthroplasty

Cementless One-stage Revision in Fast-track Setting of the Chronic Infected Hip Arthroplasty

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01015365

Acronym

CORIHA

Enrollment

Registered

2009-11-18

Start date

2009-11-30

Completion date

2017-11-30

Last updated

2017-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hip Joint Replacement, Infection

Keywords

Chronic infected hip arthroplasty, Fast-track, One-stage cementless revision

Brief summary

The investigators hypothesise that cementless one-stage exchange revision surgery can be performed in patients with chronically infected hip replacement with substantial benefits for the patients, in terms of fast rehabilitation, low re-revision rates and good long term results.

Interventions

PROCEDURECementless one-stage surgical revision

A Cementless one-stage surgical revision is to be performed for all included in the cohort.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient with clinical signs of infection for more than 4 weeks, arising from total hip arthroplasty (primary and revision), resurfacing hip arthroplasty or hemi-hip arthroplasty * Informed oral and written consent given

Exclusion criteria

* Life expectancy under 2 years * Cognitive dysfunction * Pre-operative unwillingness to receive blood * Intravenous drug abuse * Alcoholism * Immunocompromised patients * Patients receiving immunosuppressive medication * Ongoing systemic inflammatory disease * Poorly regulated diabetes mellitus * Renal failure (requiring dialysis) * Acute systemic inflammatory response syndrome with proven infection (sepsis) * Signs of coexisting active long-term local infection (i.e. endocarditis) * Previous two-stage revision of hip arthroplasty due to ipsilateral chronic infection (regardless of symptom free interval) or contralateral chronic infection (within the last 2 years). * \< 6 weeks since last surgery of the affected hip * If definition of infection is not fulfilled: infection defined as Culture positive: ≥ 3 positive intraoperative cultures (tissue biopsies a.m. Kamme-Lindberg) Culture negative: \< 3 positive intraoperative cultures (tissue biopsies a.m. Kamme-Lindberg) + Chronic fistula with history of previous or existing secretion or Positive cultures in pre-operatively joint fluid aspiration with other clinical signs of infection or Visual pus or purulent fluid during exchange procedure with clinical signs of infection

Design outcomes

Primary

Measure	Time frame
re-infection	2 years

Secondary

Measure	Time frame
Revision for other cause than infection	2 years

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026