Bone Marrow Transplantation, Mucositis
Conditions
Keywords
Mucositis, Bone Marrow Transplantation, BMT, HSCT
Brief summary
In this double blinded randomized study we evaluate effect of Zinc sulfate for prevention mucositis due to high dose chemotherapy in the patients undergoing bone marrow transplantation whose received Busulfan and/or Cyclophosphamide. Patients randomized in two groups: intervention and control with balanced block randomization method. Intervention group received Zinc sulfate immediately after start conditioning regimen and continued for two weeks. Control group received placebo at the same manner. Prevalence and severity of mucositis will be compared in two groups.
Interventions
DRUGZinc Sulfate
Zinc Sulfate: 100 mg of zinc element, per day, bid for two weeks start with chemotherapy
DRUGPlacebo
Placebo: as the same of intervention group
Sponsors
Tehran University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patient undergoing bone marrow transplantation * Signed informed consent
Exclusion criteria
* Unable take drug (or placebo) orally
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of Zinc Sulfate on prevention of mucositis in patients undergoing bone marrow transplantation | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of Zinc Sulfate concentration | 1 year |
| Evaluation of Zinc Sulfate advance effects | 1 year |
Countries
Iran
Outcome results
None listed