Cystic Fibrosis
Conditions
Brief summary
The investigators research group and others have found that patient-reported adherence to all aspects of the regimen is suboptimal and objective measures suggest even poorer adherence. There is little data, however that identifies and examines the reason for nonadherence in an adult Cystic Fibrosis (CF) population or identifies effective strategies for improving adherence. The investigators propose to evaluate the relative efficacy of a Motivational Interviewing-focused intervention (MI) in improving adherence and reducing CF-related morbidity compared to a CF education intervention (CFE; attention control group). Specifically, The investigators hypothesize that MI will result in improved regimen adherence and reduced CF morbidity compared to the CFE control group.
Interventions
BEHAVIORALMotivational Interviewing
Among a group of older adolescents and adults with CF, we propose to evaluate the relative efficacy of a Motivational Interviewing-focused intervention (MI) in improving adherence and reducing CF-related morbidity compared to a CF education intervention (CFE; attention control group).
OTHERCystic Fibrosis Education
Among a group of older adolescents and adults with CF, we propose to evaluate the relative efficacy of a Motivational Interviewing-focused intervention (MI) in improving adherence and reducing CF-related morbidity compared to a CF education intervention (CFE; attention control group). The Cystic Fibrosis Education serves as the attention control group.
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
Johns Hopkins University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Have a doctor confirmed diagnosis of CF * Age 16 years old or older * Prescribed an inhaled mucolytic, inhaled antibiotic therapy, chronic macrolide therapy and/or hypertonic saline therapy for the previous 12 months. * Scheduled for a regular visit at either the pediatric or the adult CF clinic at Johns Hopkins Hospital.
Exclusion criteria
* Burkholderia cepacia complex isolated from the respiratory tract within the past 2 years. * Had a lung transplant * Participated in NA\_00008649 A pilot study of Motivational Interviewing for adults with CF.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A medication possession ratio (MPR) will be calculated for each prescribed drug that is being monitored for adherence. | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| Change in Forced Expiratory Volume in One Second (FEV1) Percent Predicted. | 12 months |
Countries
United States
Outcome results
None listed