Anaplasmosis, Ehrlichia, Tick-borne Disease
Conditions
Brief summary
Anaplasmosis is a tick-borne transmitted infection. Its clinical expression include fever, cytopenia and hepatitis.This infection was initially described in United States. In Europe, its epidemiology is not well known. Some isolated cases have been diagnosed in several country, were the tick Ixodes ricinus is known to transmitted another infection :the Lyme borreliosis.The purpose of our study is to look systematically for Anaplasmosis, in patient living in Eastern France, and presenting with compatible clinical symptoms using a new diagnosis tool : PCR in blood samples. So we will have new data about epidemiology in our country and the clinical symptoms that are associated with Anaplasmosis.
Interventions
PROCEDUREBlood sampling
* Anaplasma diagnosis test : serology and PCR * If presence of Anaplasma infection, proposition of treatment with doxycylin 200 mg once-a-day during 10 days
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
10 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient with at least one of following symptoms : fever or muscular pain or articular pain or respiratory signs or neurological signs or meningitis or erythema occurring during the three weeks after a tick bite- * Or * patient with fever with at least one of following criteria : thrombocytopenia, leucopenia, hepatitis, without any other cause that can explain these abnormalities. * Or * patient with tick-borne encephalitis, or primary stage Lyme borreliosis
Exclusion criteria
* children less that 10 years * pregnancy * patients with an other diagnosis that can explain clinical symptoms or biological abnormalities * antibiotherapy with cyclins during the days before inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Risk factor, clinical and biological markers of infection for patients with Anaplasma antibody seroconversion | 6 weeks |
Countries
France
Contacts
Primary ContactYves HANSMANN, MD
Outcome results
None listed