Study of Biomarkers in Tissue Samples From Patients With Metastatic Colon Cancer

Assessment of Variation of PKA and Other Molecular Markers in Patients Undergoing Resection of Colon Cancer Metastases

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01012804

Enrollment

Registered

2009-11-13

Start date

2000-01-31

Completion date

Unknown

Last updated

2011-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

stage IV colon cancer, recurrent colon cancer

Brief summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is looking at biomarkers in tissue samples from patients with metastatic colon cancer.

Detailed description

OBJECTIVES: * Determine the effect of surgical resection, in terms of physiological stress, on levels of tumor markers such as protein kinase A (PKA) expression in patients with metastatic colon cancer. * Estimate variation among patients of baseline tumor markers in tumor tissue and sera. * Correlate markers in tumor tissues with that in sera in these patients. * Establish a tissue bank of these specimens for future studies. OUTLINE: Biopsy and surgical specimens are obtained before and during standard surgery (patients may have had tumor tissue obtained before study entry and stored). Serum samples and tumor tissue are analyzed by immunohistochemistry and western blot. Tumor markers (such as PKA expression) are determined and marker levels are measured in serum samples and tissues. PROJECTED ACCRUAL: Approximately 30 patients will be accrued for this study.

Interventions

GENETICwestern blotting

OTHERimmunohistochemistry staining method

OTHERlaboratory biomarker analysis

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Diagnosis of colon cancer * Metastatic disease for which surgical resection is indicated * Metastatic disease accessible for tissue biopsy OR previously biopsied tissue is available PATIENT CHARACTERISTICS: * Platelet count ≥ 80,000/mm\^3 * INR ≤ 1.3 * PTT ≤ upper limit of normal * No history of bleeding disorders or abnormal clotting factors * No extrahepatic biliary obstruction PRIOR CONCURRENT THERAPY: * See Disease Characteristics

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026