Analgesic Efficacy, Postoperative Pain
Conditions
Keywords
total knee arthroplasty, postoperative pain
Brief summary
In a randomized, double-blind, cross-over trial, 48 patients scheduled for total knee arthroplasty with placement of an intracapsular catheter will be randomized to receive bolus injection of ropivacaine in high volume/low concentration (20 ml, 5 mg/mL) or low volume/high concentration (10 mL, 10 mg/mL) 6 and 24 hours postoperatively, and pain will be assessed at rest and with mobilization for 2 hours after injections.
Interventions
DRUG20 mL ropivacaine 5 mg/mL
DRUG10 mL ropivacaine 10 mg/mL
Sponsors
Lundbeck Foundation
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Scheduled for total knee arthroplasty * Able to give informed oral and written consent to participate
Exclusion criteria
* Treatment with opioids or steroids, rheumatoid arthritis or other immunological diseases * History of stroke or any neurological or psychiatric disease potentially influencing pain perception (e.g. depression, diabetic neuropathy etc.) * Allergies to any of the drugs administered.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative pain | 32 hours postoperative |
Countries
Denmark
Outcome results
None listed