Chronic Myelomonocytic Leukemia
Conditions
Keywords
To evaluate the phosphate and tension homolog deleted on chromosome ten (PTEN) protein level in leukemia cells from patients with CMML., To identify the PTEN genetic defect in patients with deficient PTEN protein levels., To evaluate the role of PTEN deregulation in CMML pathogenesis.
Brief summary
The purpose of this study is to evaluate the level of a specific protein (PTEN) in the cancer cells of chronic myelomonocytic leukemia (CMML) patients. This protein might be involved in the transformation from normal blood cells to leukemia cells. The PTEN protein has not been investigated in CMML specifically but it has been discovered in closely related cancers. If this study demonstrates an abnormality in this protein, future testing will be designed to evaluate the genetic abnormality that resulted in lack of the normal presence of this protein. The goal is that the results of this study will help to develop new drugs and strategies to treat the future patients with CMML by understanding the abnormality of the disease at the cellular and molecular levels. The results of this study can also be utilized by future studies to develop individualized treatment to patients who have abnormal levels of this protein.
Interventions
None listed
Sponsors
University of Arkansas
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Subject must be at least 18 years or older. * Subject must sign informed consent. * For study population only, the subject must have a CMML diagnosis based on the WHO 2009 criteria. * For control population only, the subject must be deemed healthy with no hematologic disorders.
Countries
United States
Outcome results
None listed