Measured Hypocretin Levels and Recovery After Hip Surgery

Preoperative Cerebrospinal Fluid (CSF) Levels of Hypocretin and Recovery After Hip Surgery With Combined Spinal and General Anesthesia

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01009710

Enrollment

Registered

2009-11-09

Start date

2009-07-31

Completion date

2018-12-31

Last updated

2017-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis, Hip

Brief summary

A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increased hypocretin) stabilizes wakefulness; impairing or blocking these neurons (decreased hypocretin) promotes sleep. Evidence suggests that these neurons may be involved in the hypnotic properties of several anesthetics, and play a role in the induction and emergence from anesthesia. In humans there is a considerable inter-individual variability in hypocretin levels. This study aims to investigate how hypocretin levels affect the anesthetic care and recovery of patients undergoing elective hip surgery.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

- Adult (18 years of age or older) * Male or female * Scheduled for elective total hip arthroplasty at the Stanford Orthopedic Clinic. * Comprehend spoken and written English

Exclusion criteria

- ASA physical status \> III (patients with severe systemic disease) * Diagnosed psychiatric disease (except mild depression) * Any diagnoses CNS disease or dementia * History of stroke * History of untreated thyroid disease * Difficulty in airway management (ventilation and/or intubation) * Body Mass Index (BMI) \> 35 kg/m2

Design outcomes

Primary

Measure	Time frame	Description
Anesthetic Recovery Times	0-72 hours after surgery	recovery from anesthesia will be measured by short-term outcomes like time to tracheal extubation and response to verbal commands, as well as by psycho-vigilance testing up to 72 hours postoperatively

Secondary

Measure	Time frame	Description
sensitivity to sevoflurane during inhalation induction to anesthesia, determined by bispectral index of the EEG	during anesthetic induction	pharmacodynamic analysis of bispectral index of the EEG response to sevoflurane
pain and sleepiness	from 0-72 hours after surgery	assessment of pain and sleepiness using the numerical rating scale (0-10) during the 72 hours postoperatively

Countries

United States

Outcome results