Gastroesophageal Reflux
Conditions
Keywords
Gastrointestinal motility, Gastroesophageal reflux, Gastric emptying, Sodium glutamate, Lower esophageal sphincter
Brief summary
The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).
Detailed description
Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption. . To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.
Interventions
DIETARY_SUPPLEMENTMonosodium glutamate
Oral intake of 2.0 g of monosodium glutamate on the examination day and 0.6 g of sodium chloride on the other examination day.
DIETARY_SUPPLEMENTSodium chloride
Oral intake of 0.6 g of sodium chloride on the examination day and 2.0 g of monosodium glutamate on the other examination day.
Sponsors
Gunma University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjects * Must not have digestive symptoms * Must not eat within six hours of study participation
Exclusion criteria
* Regular medications for the gastrointestinal tract * Previous Helicobacter pylori infection * Previous abdominal surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gastric emptying | 0-5 hours | half emptying time |
Countries
Japan
Outcome results
None listed