Role of Exercise for Wound Healing in the Larynx

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01009632

Enrollment

Registered

2009-11-09

Start date

2004-02-29

Completion date

2005-03-31

Last updated

2009-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Phonotrauma

Brief summary

The purpose of this study is to explore quantitatively the hypothesis that resonant voice, may enhance recovery from acute laryngeal phonotrauma, based on molecular assays from human laryngeal secretions and secondarily, clinical tests.

Detailed description

The objective is to use the following operationalized question: Does a voicing mode shown to correspond to high-amplitude, low impact vocal cord oscillations, resonant voice, improve the amount and time-course of recovery from acute phonotrauma, compared to vocal rest or spontaneous speech, as measured with molecular assays (primarily) and with behavioral and clinical tests (secondarily)?

Interventions

BEHAVIORALResonant voice

4-hr of resonant voice exercise

BEHAVIORALVoice rest

4-hr of complete refrain from any voice use

BEHAVIORALSpontaneous speech

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

* males and females who have had voice training and feel they are able to produce loud voice safely; * ages 18-49; * generally healthy; * normal hearing bilaterally at 20 dB to 8,000 Hz; and * demonstrated ability to produce resonant voice during training as determined by the examiner perceptually.

Exclusion criteria

* current chronic voice problems; * current medications that are determined to possibly influence voice (e.g. diuretics, decongestants); * heightened gag reflex; * small nasal passage; * deviated septum; and * known or suspected allergy to anesthetics.

Design outcomes

Primary

Measure	Time frame
Biomarkers in laryngeal secretions	Up to 24-hour post-baseline

Secondary

Measure	Time frame
Phonation Threshold Pressure (PTP)	Up to 24-hour post baseline
Direct Magnitude Estimations of phonatory effort (DME)	Up to 24-hour post baseline
Visual-perceptual ratings of the larynx	Up to 24-hour post baseline

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026