Pain
Conditions
Keywords
pain, retinal photocoagulation, potassium diclofenac
Brief summary
The purpose of this study was to evaluate the analgesic effect of oral potassium diclofenac in patients with proliferative diabetic retinopathy submitted to retinal photocoagulation. Two groups of patients were followed and the effect of the treatment (diclofenac plus laser) was compared to placebo (placebo plus laser). Pain associated with treatment was recorded using a Visual Analog Scale 15 minutes after the procedure.
Interventions
DRUGpotassium diclofenac
potassium diclofenac 50 mg, one tablet 45 minutes before laser treatment
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 1)high-risk proliferative diabetic retinopathy in both eyes
Exclusion criteria
* 1)history of prior laser treatment or vitrectomy; 2) allergy to non-steroidal anti-inflammatory drugs; 3) any condition affecting comprehension of VAS pain score test; 4) Contra-indications for diclofenac use such as pregnancy, bleeding disorders, asthma, or renal failure; 5) use of any analgesic drug for the last 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain recorded using a Visual Analog Scale | 15 minutes after the procedure |
Countries
Brazil
Outcome results
None listed