Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis

Is Antibiotic Therapy Mandatory for Treatment of Uncomplicated Acute Colonic Diverticulitis: a Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01008488

Enrollment

600

Registered

2009-11-05

Start date

2002-11-30

Completion date

2010-12-31

Last updated

2011-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colonic Diverticulitis

Keywords

colonic diverticulitis, diverticular disease, antibiotic therapy

Brief summary

The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis. The hypothesis is that Patients with acute uncomplicated colonic diverticulitis will recover the condition without antibiotic therapy and the lack of antibiotic therapy will not lead to complications. The patients will be randomized to conservative treatment with and without antibiotic therapy.

Interventions

DRUGAntibiotic

Antibiotic according to local treatment routine against bowel pathogenesis

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* adults with CT sign of acute colonic uncomplicated diverticulitis * elevated CRP and LPK * Temp.38c or more

Exclusion criteria

* patients with peritonitis, sepsis or CT- sign of complicated diverticulitis with abscesses or free abdominal air * pregnancy * immunological incompetence and immunosuppressive therapy

Design outcomes

Primary

Measure	Time frame
discharge without complications +/- antibiotic therapy	Within 30 days after discharge

Secondary

Measure	Time frame
to evaluate length of hospital stay, cost and late complications	one year after admission

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026