Effect of Dexamethasone Combined With Ondansetron on Postoperative Nausea and Vomiting in Patients With Patient-controlled Analgesia After Video-assisted Thoracoscopic Surgery

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01007500

Enrollment

123

Registered

2009-11-04

Start date

2009-09-30

Completion date

2010-09-30

Last updated

2016-12-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea, Vomiting

Keywords

Postoperative nausea and vomiting after video-assisted thoracoscopic surgery

Brief summary

The purpose of this study is to study the effect of dexamethasone combined with ondansetron on postoperative nausea and vomiting in patients with patient-controlled analgesia after video-assisted thoracoscopic surgery.

Interventions

DRUGDexamethasone

Experimental: Dexamethasone 8 mg IV after induction of anesthesia, Ondansetron 4 mg IV at the end of surgery and 12 mg mix to intravenous patient controlled analgesia device.

DRUGOndansetron

Active comparator: Ondansetron 4 mg IV at the end of surgery and 12 mg mix to intravenous patient controlled analgesia device.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing video-assisted thoracoscopic surgery * Age 20-75 * American Society of Anesthesiologists physical status classification I or II

Exclusion criteria

* Antiemetic within 24 hrs * Taking Steroids, Opioids within 1 week * Active drug or alcohol abuse * GI motility disorder, severe renal/ hepatic disease.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative nausea and vomiting	within 48 hrs after surgery

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026