Antibacterial Properties of Silicon Incorporated With Quaternary Ammonium Polyethylenimine Nanoparticles

Clinical Study of the Antibacterial Properties of the Nano Particles Which Incorporated With the Soft Liner Silicone - in Obturators

Status

UNKNOWN

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01007240

Enrollment

Registered

2009-11-04

Start date

2010-01-31

Completion date

2010-12-31

Last updated

2009-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carcinoma of Head and Neck

Keywords

head and neck carcinoma, obturators, maxillectomy, soft liner, nano particles, antibacterial properties, patients post maxillectomy

Brief summary

The aim of this study is to evaluate the antibacterial activity of crosslinked quaternary ammonium polyethylenimine (PEI) nanoparticles incorporated at 1-2% w/w in a commercial soft liner material when compared to the commercial soft liner material. The investigators' results in vitro showed a significant delay in bacterial growth. Therefore, the investigators assume to have the same delay in vivo- on patients.

Interventions

DEVICEpolyethylenimine (PEI) nanoparticles.

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* patients post maxillectomy, who are using obturators

Exclusion criteria

* patients who are not using obturators

Design outcomes

Primary

Measure	Time frame
bacterial growth	a week

Contacts

Primary Contactanat b sharon, Msc, DMD

anatsharon@hadassah.org.il972-54-5255659

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026