Trauma
Conditions
Keywords
pain, trauma, propranolol
Brief summary
The purpose of this study is to determine whether propranolol can decrease pain symptoms in a common subset of patients admitted to a trauma center after injury.
Detailed description
The main purpose of this pilot study is to investigate Propranolol's utility in the trauma population. Specifically, to see if it reduces pain scores post-injury.
Interventions
Sponsors
University of North Carolina, Chapel Hill
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* at least one fracture * ages 18-60 yrs * pain score \>= 4 * speak and read English
Exclusion criteria
* gunshot, stab wound, or assault * paraplegia/quadriplegia * pregnancy * psychotic, suicidal, or homicidal * hepatic, kidney failure * clinically unstable or intubated at time of recruitment * hyperthyroidism * propranolol use within the last 6 months * significant bradycardia * cancer (except basal cell) * peripheral vascular disease * heart block \> 1 degree * breastfeeding * congestive heart failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Daily average pain score (0-10 numeric rating pain score recorded daily from patient) after study drug initiation. | Study days 1, 3, 5, 7, 10, 13, 17, and 19 |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality | MOS Sleep Scale |
| Anxiety symptoms | 7 days, 6 weeks, 3 months, 6 months |
Countries
United States
Outcome results
None listed