Infertility
Conditions
Keywords
Poor responder, Flare up, Micro dose GnRH agonist flare up, IVF/ICSI
Brief summary
About 9 to 24 % of women undergoing in vitro fertilization (IVF) treatment respond poorly to the usual gonadotrophin stimulation protocol applied. Several induction ovulation treatments have been suggested for increasing pregnancy rate. In this study, the investigators will compare the outcome of Microflare protocol and Flare up regimen in poor responders.
Detailed description
In this randomized clinical trial study, a total of 200 infertile women with poor ovarian response who undergo IVF / ICSI treatment cycle at Royan Institute will enroll in this study and will randomly be divided into two groups of 100 patients. This study has been approved by Royan ethics committee and written consent will be obtained from each patient. The patients will be randomized to one of two groups of Flare Up or Microdose GnRh agonist flare up. Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Estradiol, will be evaluated on day 2 or 3 and when follicle size become \>14. 2 weeks after embryo transfer, the patients will be tested for serum β-hCG for assessing the pregnancy. The clinical pregnancy will be clarified by the number of women with gestational sacs on transvaginal sonography at 4-6 weeks of gestation. In the calculation of implantation, the number of gestational sacs will be considered.
Interventions
DRUGMicrodose GnRh
Microflare protocol in poor responders for IVF/ICSI
DRUGFlare up
Flare up protocol in poor responders for IVF/ICSI
Sponsors
Royan Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
Poor responders (Presence of at least two of following items is necessary for inclusion to the study) * History of Cycle Cancellation * History of oocyte number 3 (in previous cycle) * History of Number of antral follicle \< 5 in previous cycle * Age≥38 * FSH\>12 on day 2 or 3 * Ovarian Volume 3 cm3
Exclusion criteria
* Male factor (azospermi) * Myoma ≥6cm * One way ovary * Tumor or cyst \>13mm * Age \>42
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| Cycle cancellation rates | 12 Months |
| Number of oocytes generated | 12 Months |
| Number of embryos generated | 12 Months |
| Implantation rate | 12 Months |
| Pregnancy rate | 12 months |
Countries
Iran
Outcome results
None listed