Prostate Cancer
Conditions
Keywords
Magnetic Resonance Imaging, Prostate Cancer, Magnetic Resonance Spectroscopy, Radiotherapy planning
Brief summary
To determine if functional MRI methods will aid planning of a radiation dose boost within the prostate in patients with prostate cancer potentially improving safety and efficacy.
Interventions
OTHERImaging Investigations (not radiation)
Pre-hormone therapy MRI scans will be performed as an adjunct to the patients' staging MRI scan; post hormone MRI will be done wholly for research purposes.
OTHEROther
Insertion of gold seeds into prostate for image registration.
Sponsors
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Eligibility
Sex/Gender
MALE
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Hormone therapy naive patients planned to be treated by radical radiotherapy after 3-6 months of androgen suppression * Patients with low-high risk histologically confirmed localised disease are eligible, with WHO performance status 0-1.
Exclusion criteria
* Patients unsuitable for functional MRI of the prostate or gold seed fiducial marker insertion (e.g. patients unable to tolerate endorectal MRI examination). * No prior pelvic radiotherapy or radical prostatectomy, previous androgen therapy, patients unsuitable for radical radiotherapy, life expectancy \<10 years, previous active malignancy within last 5 years, co-morbid conditions likely to impact on the advisability of radical radiotherapy, full anticoagulation, other exclusions to MRI (e.g. hip prosthesis or fixation, claustrophobia, ferromagnetic implants).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of dose distributions produced by rival radiotherapy plans judged using radiobiological model predictions of Tumour Control Probability (TCP) and Normal Tissue Complication Probability (NTCP). | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of reproducibility of registration algorithms for mapping functional MR data acquired before hormone therapy to MR anatomical data acquired after hormone therapy and prior to radiotherapy. | — |
| Comparison of reproducibility of registration of functional and MR data with computed tomography (CT) data using gold seed registration, assessing reproducibility and positioning issues. | — |
| Comparison of image quality, registration reproducibility and gland distortion of internal and external imaging coils for MRI image acquisition and registration of the prostate. | — |
| Comparison of dose distributions produced by rival radiotherapy plans judged using three standard dose-volume constraints for targets and normal tissues and careful examination of the 3D dose distribution. | — |
Countries
United Kingdom
Contacts
Primary ContactDr Nandita deSouza
Outcome results
None listed