Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy

A PHASE 1, DOUBLE-MASKED, PLACEBO-CONTROLLED STUDY EVALUATING THE SAFETY, TOLERABILITY, IMMUNOGENICITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF MULTIPLE ESCALATING DOSAGES OF RN6G (PF-04382923) IN SUBJECTS WITH ADVANCED DRY, AGE-RELATED MACULAR DEGENERATION (AMD) INCLUDING GEOGRAPHIC ATROPHY

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01003691

Enrollment

Registered

2009-10-29

Start date

2010-08-05

Completion date

2013-04-19

Last updated

2022-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age-Related Maculopathies, Age-Related Maculopathy, Eye Diseases, Macular Degeneration, Retinal Degeneration

Keywords

Phase 1b Advanced Dry Age-Related Macular Degeneration RN6G

Brief summary

The purpose of this study is to determine the safety and tolerability of multiple doses of RN6G in subjects with advanced dry, age-related macular degeneration including geographic atrophy.

Interventions

BIOLOGICALRN6G

Intravenous, multiple dose, dose ranging from 5 mg/kg up to a maximum of 15 mg/kg

BIOLOGICALPlacebo

Intravenous, multiple dose with experimental dose

Study design

Allocation

RANDOMIZED

Intervention model

SEQUENTIAL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

60 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Be of non-child bearing potential * Diagnosis of dry AMD including uni- or multi-focal geographic atrophy without foveal involvement * BCVA of 20/50 or better in the study eye

Exclusion criteria

* Evidence of ocular disease other than advanced AMD or GA in the study eye * History or diagnosis of exudative (wet) AMD, with subretinal or choroidal neovascular lesions in the study eye * Presence of disease or condition that might compromise the cardiovascular, hematological, renal, hepatic, pulmonary, endocrine, central nervous immune, or gastrointestinal system * Requires ocular or systemic medications that are known to be toxic to the lens, retina or optic nerve

Design outcomes

Primary

Measure	Time frame	Description
Number of Participants With Toxicity or Intolerable Dose Criteria	Baseline up to Day 304/End of Treatment (ET)	The dose was considered intolerable if a participant developed either ocular toxicity or other toxicity as per Common Terminology Criteria for Adverse Events (CTCAE) or based on the investigator's discretion. Ocular toxicity included: Grade \>= 3 (retinopathy, retinal detachment, cataract formation, optic disk edema, keratitis, vitreous hemorrhage and uveitis) and acute vision loss of greater than 3 lines of vision up to and including 140 days after the first dose. Other toxicity included serious adverse event (SAE), Grade \>= 3 (increased liver transaminases, encephalopathy/leukoencephalopathy, diarrhea, enteritis or nausea, prolongation of QT interval \[Fridericia's correction\]), Grade \>=2 (central nervous system hemorrhage, decreased total leukocyte count, increased serum creatinine) and thrombocytopenia \<100\*10 9 /liter.
Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Baseline up to Day 304/ET	AE was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. AE was assessed according to severity; Grade 1 (mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated), Grade 2 (moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental activities of daily living \[ADL\]), Grade 3 (severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL), Grade 4 (life-threatening consequences; urgent intervention indicated) and Grade 5 (death related to AE).
Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	Baseline up to Day 304/ET	All causalities AE was any untoward medical occurrence in participant who received study drug without regard to causal relationship. Drug-related AE was any untoward medical occurrence attributed to study drug in a participant who received study drug. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. All causalities and drug-related AEs reported wherein drug-related AEs were reported as ocular and non-ocular AEs. Ocular AEs were events which were localized in the ocular region and non-ocular AEs were systemic events which were not localized but occurred throughout the systemic circulation.
Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Baseline up to Day 304/ET	AE was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. Ocular AE were events which were localized in the ocular region and was assessed according to severity; Grade 1 (mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated), Grade 2 (moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL), Grade 3 (severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL), Grade 4 (life-threatening consequences; urgent intervention indicated) and Grade 5 (death related to AE).
Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Baseline up to Day 304/ET	AE was any untoward medical occurrence in participant who received study drug without regard to causal relationship and drug-related AE was any untoward medical occurrence attributed to study drug in a participant who received study drug. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. Ocular AEs were events which were localized in the ocular region. Ocular AEs reported as related and non-related to study drug.
Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Baseline up to Day 304/ET	AE was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. Systemic AE were events which were not localized but occurred throughout the systemic circulation and was assessed according to severity; Grade 1 (mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated), Grade 2 (moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL), Grade 3 (severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL), Grade 4 (life-threatening consequences; urgent intervention indicated) and Grade 5 (death related to AE).
Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Baseline up to Day 304/ET	AE was any untoward medical occurrence in participant who received study drug without regard to causal relationship and drug-related AE was any untoward medical occurrence attributed to study drug in a participant who received study drug. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. Systemic TEAEs were events which were not localized but occurred throughout the systemic circulation and reported as related and non-related to study drug.
Number of Participants With Positive Anti-Drug-Antibodies (ADA) and Neutralizing Antibodies (Nab)	Baseline up to Day 304/ET	The immunogenicity of RN6G (PF-04382923) in terms of producing an antidrug antibody (ADA) and neutralizing antibody response were assessed. Neutralizing antibody response were to be assess in participants with positive ADA samples.

Secondary

Measure	Time frame	Description
Plasma Decay Half-Life (t1/2) of RN6G (PF-04382923)	Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140	Plasma decay half-life is the time measured for the plasma concentration to decrease by one half.
Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline, Day 1 (1 hour, 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET	Amyloid (A) Beta (1-X) is a primary activator of complement in Alzheimer's disease (AD).
Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Baseline, 1 and 4 H post-dose on Day 1; 24 H post-dose on Days 2 and 141; pre-dose and 4 - 8 H post-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 7, 14, 19, 45, 75, 103;131, 141, 154 168, 224 and 304/ET	—
Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Day 1 (1 hour , 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET	—
Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline, Day 1 (1 hour , 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET	—
Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Day 1 (1 hour, 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET	—
Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline, Day 1 (1 hour, 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET	—
Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Day 1 (1 hour, 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET	—
Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Baseline, 1 and 4 hour (H) post-dose on Day 1; 24 H post-dose on Days 2 and 141; pre-dose and 4 - 8 H post-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 7, 14, 19, 45, 75, 103;131, 141, 154 168, 224 and 304/ET	—
Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Baseline, 1 and 4 H post-dose on Day 1; 24 H post-dose on Days 2 and 141; pre-dose and 4 - 8 H post-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 7, 14, 19, 45, 75, 103;131, 141, 154 168, 224 and 304/ET	—
Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Baseline, 1 and 4 H post-dose on Day 1; 24 H post-dose on Days 2 and 141; pre-dose and 4 - 8 H post-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 7, 14, 19, 45, 75, 103;131, 141, 154 168, 224 and 304/ET	—
Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, 1 and 4 H post-dose on Day 1; pre-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 168, 224 and 304/ET	Criteria for changes in ECG (12-lead) were defined as: PR interval \>=220 millisecond (msec) and increase of \>=20 msec; QRS interval \>=120 msec; QT interval corrected using the Bazett's formula (QTcB) \>=500 msec; Maximum Change from Baseline in QTcF at Borderline \>=30 msec to \<60 msec and Prolonged \>=60 msec.
Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, 1 and 4 H post-dose on Day 1; pre-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 168, 224 and 304/ET	—
Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Following parameters were analyzed for laboratory examination: Bilirubin, Direct Bilirubin, Blood Urea Nitrogen(BUN), Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol (CL)(Fasting), Triglycerides (Fasting) (TG), Immunoglobulin G (Ig G), Immunoglobulin A (Ig A), Immunoglobulin M (Ig M)
Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	—
Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Following parameters were analyzed for laboratory examination: Aspartate Aminotransferase (AMT), Creatine Kinase (CK), Alanine Aminotransferase (ALT), Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase (LD), Alkaline Phosphatase (AP).
Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	—
Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Following hematology parameters were analyzed for laboratory examination: Hemoglobin, Hematocrit, Red blood cell (RBC) count, Platelet count, WBC count, Total neutrophils (Abs),Eosinophils (Abs),Monocytes (Abs),Basophils (Abs), Lymphocytes (Abs).
Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	—
Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of RN6G (PF-04382923)	Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 168, 336 hours on Day 1 and 1, 2, 4, 24, 336, 672 hours on Day 140	Area under the concentration-time profile from time zero to time tau (τ), the dosing interval, where tau = 672 hours.
Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Following hematology parameters were analyzed for laboratory examination: Prothrombin Time (PT), Partial Thromboplastin Time.
Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Urine specific gravity is a measure of the ratio of the density of urine to the density of water.
Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Urine pH is a method for evaluating urine acidity measured on a 10-point scale ranging from 0 (most acidic) to 9 (most alkaline). A lower pH means more acidity.
Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline, Day 28, 56, 84, 112, 140	—
Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Baseline, Day 28, 56, 84, 112, 140	—
Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Baseline, Day 28, 56, 84, 112, 140	—
Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	—
Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, 1 and 4 H post-dose on Day 1; pre-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 168, 224 and 304/ET	QT interval corrected using the Fridericia formula (QTcF) \>=500 msec; Maximum Change from Baseline in QTcF at Borderline \>=30 msec to \<60 msec and Prolonged \>=60 msec.
Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET	—
Maximum Observed Plasma Concentration (Cmax) of RN6G (PF-04382923)	Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 168, 336 hours on Day 1 and 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140	—
Minimum Observed Plasma Trough Concentration (Cmin) of RN6G (PF-04382923)	Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140	—
Plasma Concentration (Css) at Steady State of RN6G (PF-04382923)	Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140	Css is the concentration of the drug at the state when the amount of drug administered is equal to the amount of drug eliminated.
Time to Reach Maximum Observed Plasma Concentration (Tmax) of RN6G (PF-04382923)	Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 168, 336 hours on Day 1 and 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140	—
Volume of Distribution at Steady State (Vss) of RN6G (PF-04382923)	Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140	Volume of distribution is defined as the theoretical volume in which the total amount of drug would need to be uniformly distributed to produce the desired blood concentration of a drug. Steady state volume of distribution (Vss) is the apparent volume of distribution at steady-state.
Mean Residence Time (MRT) of RN6G (PF-04382923)	Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140	The mean total time drug resides in the body.
Systemic Clearance (CL) of RN6G (PF-04382923)	Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140	CL is a quantitative measure of the rate at which a drug substance is removed from the body.

Countries

United States

Participant flow

Participants by arm

Arm	Count
RN6G 5 mg/kg RN6G (PF-04382923) 5 milligram/kilogram (mg/kg) of body weight, intravenous infusion over 60 minutes every 4 weeks until unacceptable toxicity, up to Month 5.	6
RN6G 10 mg/kg RN6G (PF-04382923) 10 mg/kg of body weight, intravenous infusion over 60 minutes every 4 weeks until unacceptable toxicity, up to Month 5.	6
RN6G 15 mg/kg RN6G (PF-04382923) 15 mg/kg of body weight, intravenous infusion over 60 minutes every 4 weeks until unacceptable toxicity, up to Month 5.	6
Placebo Placebo intravenous infusion over 60 minutes, every 4 weeks, until unacceptable toxicity, up to Month 5.	6
Total	24

Withdrawals & dropouts

Period	Reason	FG000	FG001	FG002	FG003
Overall Study	Adverse Event	0	0	0	1

Baseline characteristics

Characteristic	RN6G 5 mg/kg	RN6G 10 mg/kg	RN6G 15 mg/kg	Placebo	Total
Age, Customized 60 to less than (<) 75 years	3 Participants	3 Participants	3 Participants	2 Participants	11 Participants
Age, Customized Greater than or equal to (>=) 75 years	3 Participants	3 Participants	3 Participants	4 Participants	13 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	0 Participants	0 Participants	0 Participants	1 Participants	1 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	6 Participants	6 Participants	6 Participants	5 Participants	23 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Asian	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Black or African American	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) More than one race	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants	0 Participants	0 Participants	1 Participants	1 Participants
Race (NIH/OMB) White	6 Participants	6 Participants	6 Participants	5 Participants	23 Participants
Sex: Female, Male Female	4 Participants	1 Participants	5 Participants	3 Participants	13 Participants
Sex: Female, Male Male	2 Participants	5 Participants	1 Participants	3 Participants	11 Participants

Adverse events

Event type	EG000 affected / at risk	EG001 affected / at risk	EG002 affected / at risk	EG003 affected / at risk
deaths Total, all-cause mortality	0 / 6	0 / 6	0 / 6	0 / 6
other Total, other adverse events	6 / 6	6 / 6	6 / 6	6 / 6
serious Total, serious adverse events	0 / 6	0 / 6	2 / 6	0 / 6

Outcome results

Primary

Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug

AE was any untoward medical occurrence in participant who received study drug without regard to causal relationship and drug-related AE was any untoward medical occurrence attributed to study drug in a participant who received study drug. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. Ocular AEs were events which were localized in the ocular region. Ocular AEs reported as related and non-related to study drug.

Time frame: Baseline up to Day 304/ET

Population: Safety analysis set included all randomized participants who received at least 1 dose of study drug or placebo.

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
RN6G 5 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Related	0 Participants
RN6G 5 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Not Related	4 Participants
RN6G 10 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Not Related	4 Participants
RN6G 10 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Related	0 Participants
RN6G 15 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Related	0 Participants
RN6G 15 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Not Related	3 Participants
Placebo	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Related	0 Participants
Placebo	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Not Related	4 Participants

Primary

Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity

AE was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. Ocular AE were events which were localized in the ocular region and was assessed according to severity; Grade 1 (mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated), Grade 2 (moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL), Grade 3 (severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL), Grade 4 (life-threatening consequences; urgent intervention indicated) and Grade 5 (death related to AE).

Time frame: Baseline up to Day 304/ET

Population: Safety analysis set included all randomized participants who received at least 1 dose of study drug or placebo.

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
RN6G 5 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
RN6G 5 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	4 Participants
RN6G 5 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants
RN6G 5 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	0 Participants
RN6G 5 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	0 Participants
RN6G 10 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	0 Participants
RN6G 10 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
RN6G 10 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	0 Participants
RN6G 10 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	4 Participants
RN6G 10 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants
RN6G 15 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	3 Participants
RN6G 15 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	0 Participants
RN6G 15 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	0 Participants
RN6G 15 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
RN6G 15 mg/kg	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants
Placebo	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
Placebo	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	2 Participants
Placebo	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	2 Participants
Placebo	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	0 Participants
Placebo	Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants

Primary

Number of Participants With Positive Anti-Drug-Antibodies (ADA) and Neutralizing Antibodies (Nab)

The immunogenicity of RN6G (PF-04382923) in terms of producing an antidrug antibody (ADA) and neutralizing antibody response were assessed. Neutralizing antibody response were to be assess in participants with positive ADA samples.

Time frame: Baseline up to Day 304/ET

Population: Analysis population included all randomized participants who met the inclusion criteria and received any amount of study drug. Here Number Analyzed signifies number of participants evaluated for specified category. Data for Nab was not estimable as no participant was eligible for neutralizing antibody assessment, as there were no positive ADA samples.

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
RN6G 5 mg/kg	Number of Participants With Positive Anti-Drug-Antibodies (ADA) and Neutralizing Antibodies (Nab)	Positive ADA	0 Participants
RN6G 10 mg/kg	Number of Participants With Positive Anti-Drug-Antibodies (ADA) and Neutralizing Antibodies (Nab)	Positive ADA	0 Participants
RN6G 15 mg/kg	Number of Participants With Positive Anti-Drug-Antibodies (ADA) and Neutralizing Antibodies (Nab)	Positive ADA	0 Participants
Placebo	Number of Participants With Positive Anti-Drug-Antibodies (ADA) and Neutralizing Antibodies (Nab)	Positive ADA	0 Participants

Primary

Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug

AE was any untoward medical occurrence in participant who received study drug without regard to causal relationship and drug-related AE was any untoward medical occurrence attributed to study drug in a participant who received study drug. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. Systemic TEAEs were events which were not localized but occurred throughout the systemic circulation and reported as related and non-related to study drug.

Time frame: Baseline up to Day 304/ET

Population: Safety analysis set included all randomized participants who received at least 1 dose of study drug or placebo.

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
RN6G 5 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Related	2 Participants
RN6G 5 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Not related	4 Participants
RN6G 10 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Not related	6 Participants
RN6G 10 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Related	0 Participants
RN6G 15 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Not related	6 Participants
RN6G 15 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Related	0 Participants
Placebo	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Related	0 Participants
Placebo	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug	Not related	6 Participants

Primary

Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity

AE was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. Systemic AE were events which were not localized but occurred throughout the systemic circulation and was assessed according to severity; Grade 1 (mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated), Grade 2 (moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL), Grade 3 (severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL), Grade 4 (life-threatening consequences; urgent intervention indicated) and Grade 5 (death related to AE).

Time frame: Baseline up to Day 304/ET

Population: Safety analysis set included all randomized participants who received at least 1 dose of study drug or placebo.

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
RN6G 5 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
RN6G 5 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	0 Participants
RN6G 5 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	5 Participants
RN6G 5 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	1 Participants
RN6G 5 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants
RN6G 10 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants
RN6G 10 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	3 Participants
RN6G 10 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
RN6G 10 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	3 Participants
RN6G 10 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	0 Participants
RN6G 15 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	2 Participants
RN6G 15 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	4 Participants
RN6G 15 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	0 Participants
RN6G 15 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
RN6G 15 mg/kg	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants
Placebo	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	5 Participants
Placebo	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
Placebo	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants
Placebo	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	0 Participants
Placebo	Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	1 Participants

Primary

Number of Participants With Toxicity or Intolerable Dose Criteria

The dose was considered intolerable if a participant developed either ocular toxicity or other toxicity as per Common Terminology Criteria for Adverse Events (CTCAE) or based on the investigator's discretion. Ocular toxicity included: Grade \>= 3 (retinopathy, retinal detachment, cataract formation, optic disk edema, keratitis, vitreous hemorrhage and uveitis) and acute vision loss of greater than 3 lines of vision up to and including 140 days after the first dose. Other toxicity included serious adverse event (SAE), Grade \>= 3 (increased liver transaminases, encephalopathy/leukoencephalopathy, diarrhea, enteritis or nausea, prolongation of QT interval \[Fridericia's correction\]), Grade \>=2 (central nervous system hemorrhage, decreased total leukocyte count, increased serum creatinine) and thrombocytopenia \<100\*10 9 /liter.

Time frame: Baseline up to Day 304/End of Treatment (ET)

Population: Safety analysis set included all randomized participants who received at least 1 dose of study drug or placebo.

Arm	Measure	Value (NUMBER)
RN6G 5 mg/kg	Number of Participants With Toxicity or Intolerable Dose Criteria	0 Participants
RN6G 10 mg/kg	Number of Participants With Toxicity or Intolerable Dose Criteria	0 Participants
RN6G 15 mg/kg	Number of Participants With Toxicity or Intolerable Dose Criteria	0 Participants
Placebo	Number of Participants With Toxicity or Intolerable Dose Criteria	0 Participants

Primary

Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug

All causalities AE was any untoward medical occurrence in participant who received study drug without regard to causal relationship. Drug-related AE was any untoward medical occurrence attributed to study drug in a participant who received study drug. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. All causalities and drug-related AEs reported wherein drug-related AEs were reported as ocular and non-ocular AEs. Ocular AEs were events which were localized in the ocular region and non-ocular AEs were systemic events which were not localized but occurred throughout the systemic circulation.

Time frame: Baseline up to Day 304/ET

Population: Safety analysis set included all randomized participants who received at least 1 dose of study drug or placebo.

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
RN6G 5 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	All causalities AE	6 Participants
RN6G 5 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	Drug-related non-ocular AE	2 Participants
RN6G 5 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	Drug-related Ocular AE	0 Participants
RN6G 10 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	All causalities AE	6 Participants
RN6G 10 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	Drug-related non-ocular AE	0 Participants
RN6G 10 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	Drug-related Ocular AE	0 Participants
RN6G 15 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	Drug-related Ocular AE	0 Participants
RN6G 15 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	All causalities AE	6 Participants
RN6G 15 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	Drug-related non-ocular AE	0 Participants
Placebo	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	All causalities AE	6 Participants
Placebo	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	Drug-related non-ocular AE	0 Participants
Placebo	Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug	Drug-related Ocular AE	0 Participants

Primary

Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity

AE was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. Treatment-emergent are events between first dose of study drug and up to Day 304/ET that were absent before treatment or that worsened relative to pretreatment state. AE was assessed according to severity; Grade 1 (mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated), Grade 2 (moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental activities of daily living \[ADL\]), Grade 3 (severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL), Grade 4 (life-threatening consequences; urgent intervention indicated) and Grade 5 (death related to AE).

Time frame: Baseline up to Day 304/ET

Population: Safety analysis set included all randomized participants who received at least 1 dose of study drug or placebo.

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
RN6G 5 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
RN6G 5 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	5 Participants
RN6G 5 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants
RN6G 5 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	0 Participants
RN6G 5 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	1 Participants
RN6G 10 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	0 Participants
RN6G 10 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
RN6G 10 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants
RN6G 10 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	3 Participants
RN6G 10 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	3 Participants
RN6G 15 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	2 Participants
RN6G 15 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	0 Participants
RN6G 15 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	4 Participants
RN6G 15 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
RN6G 15 mg/kg	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants
Placebo	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 4	0 Participants
Placebo	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 2	5 Participants
Placebo	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 1	0 Participants
Placebo	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 3	1 Participants
Placebo	Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity	Grade 5	0 Participants

Secondary

Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of RN6G (PF-04382923)

Area under the concentration-time profile from time zero to time tau (τ), the dosing interval, where tau = 672 hours.

Time frame: Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 168, 336 hours on Day 1 and 1, 2, 4, 24, 336, 672 hours on Day 140

Population: Analysis population included all randomized participants who met the inclusion criteria and received any amount of study drug. Here Overall Number of participants Analyzed signifies number of participants evaluable for this outcome measure and Number Analyzed signifies number of participants evaluated for specified category.

Arm	Measure	Group	Value (GEOMETRIC_MEAN)	Dispersion
RN6G 5 mg/kg	Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of RN6G (PF-04382923)	Day 1	NA Microgramhour per milliliter (mcgh/mL)	—
RN6G 5 mg/kg	Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of RN6G (PF-04382923)	Day 140	50230 Microgramhour per milliliter (mcgh/mL)	Geometric Coefficient of Variation 20
RN6G 10 mg/kg	Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of RN6G (PF-04382923)	Day 140	140300 Microgramhour per milliliter (mcgh/mL)	Geometric Coefficient of Variation 14
RN6G 15 mg/kg	Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of RN6G (PF-04382923)	Day 1	NA Microgramhour per milliliter (mcgh/mL)	—
RN6G 15 mg/kg	Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of RN6G (PF-04382923)	Day 140	213200 Microgramhour per milliliter (mcgh/mL)	Geometric Coefficient of Variation 16

Secondary

Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET

Criteria for changes in ECG (12-lead) were defined as: PR interval \>=220 millisecond (msec) and increase of \>=20 msec; QRS interval \>=120 msec; QT interval corrected using the Bazett's formula (QTcB) \>=500 msec; Maximum Change from Baseline in QTcF at Borderline \>=30 msec to \<60 msec and Prolonged \>=60 msec.

Time frame: Baseline, 1 and 4 H post-dose on Day 1; pre-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 168, 224 and 304/ET

Population: Safety analysis set included all randomized participants who received any amount of study drug. Here Number Analyzed signifies number of participants evaluated for given time point.

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: RR	-36.28 Millisecond	Standard Deviation 38.148
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QTcB	-2.06 Millisecond	Standard Deviation 16.679
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: PR	-6.78 Millisecond	Standard Deviation 9.27
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QTcB	-0.61 Millisecond	Standard Deviation 9.855
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QT	-3.78 Millisecond	Standard Deviation 18.493
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QTcB	-6.39 Millisecond	Standard Deviation 18.637
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QTcB	-6.39 Millisecond	Standard Deviation 17.989
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: PR	0.22 Millisecond	Standard Deviation 6.885
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QRS	-4.44 Millisecond	Standard Deviation 5.106
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: RR	5.39 Millisecond	Standard Deviation 61.533
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QTcB	-2.11 Millisecond	Standard Deviation 6.493
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: PR	-0.78 Millisecond	Standard Deviation 12.567
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QT	-2.33 Millisecond	Standard Deviation 11.939
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QT	-1.33 Millisecond	Standard Deviation 13.367
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QTcB	4.44 Millisecond	Standard Deviation 13.274
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: PR	2.33 Millisecond	Standard Deviation 8.892
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: RR	939.28 Millisecond	Standard Deviation 124.486
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: RR	-33.11 Millisecond	Standard Deviation 80.934
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QTcB	-5.39 Millisecond	Standard Deviation 11.496
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: PR	-3.33 Millisecond	Standard Deviation 7.76
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: RR	21.72 Millisecond	Standard Deviation 77.289
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QRS	-2.44 Millisecond	Standard Deviation 6.017
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QTcB	0.39 Millisecond	Standard Deviation 4.823
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: PR	-4.33 Millisecond	Standard Deviation 9.177
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QRS	-2.56 Millisecond	Standard Deviation 3.538
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: RR	-7.61 Millisecond	Standard Deviation 53.735
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QT	-4.67 Millisecond	Standard Deviation 24.909
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PR	-4.11 Millisecond	Standard Deviation 8.405
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QT	-1.00 Millisecond	Standard Deviation 5.379
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: RR	-6.78 Millisecond	Standard Deviation 120.518
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QTcB	418.56 Millisecond	Standard Deviation 13.605
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PR	-7.11 Millisecond	Standard Deviation 14.09
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QTcB	-6.89 Millisecond	Standard Deviation 9.135
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: RR	4.06 Millisecond	Standard Deviation 45.449
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PR	170.78 Millisecond	Standard Deviation 23.268
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: RR	-44.61 Millisecond	Standard Deviation 76.284
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QTcB	0.72 Millisecond	Standard Deviation 9.525
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QT	-3.44 Millisecond	Standard Deviation 12.274
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QRS	87.11 Millisecond	Standard Deviation 5.036
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QT	405.00 Millisecond	Standard Deviation 25.174
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: RR	30.56 Millisecond	Standard Deviation 23.478
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QT	-1.67 Millisecond	Standard Deviation 6.782
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QRS	-2.67 Millisecond	Standard Deviation 4.881
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: PR	-4.22 Millisecond	Standard Deviation 13.589
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QRS	-2.22 Millisecond	Standard Deviation 3.202
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: RR	29.56 Millisecond	Standard Deviation 40.059
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QRS	-1.78 Millisecond	Standard Deviation 4.856
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QTcB	-0.89 Millisecond	Standard Deviation 8.516
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: PR	-1.33 Millisecond	Standard Deviation 9.762
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QT	-13.00 Millisecond	Standard Deviation 17.255
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QRS	1.56 Millisecond	Standard Deviation 4.375
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QRS	-2.67 Millisecond	Standard Deviation 4.638
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QT	-2.33 Millisecond	Standard Deviation 15.769
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1H post-dose Day 1: QT	1.22 Millisecond	Standard Deviation 14.27
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QRS	-1.44 Millisecond	Standard Deviation 2.083
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: PR	-2.78 Millisecond	Standard Deviation 11.711
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: RR	-6.39 Millisecond	Standard Deviation 43.272
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QT	-10.22 Millisecond	Standard Deviation 12.174
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QRS	-2.11 Millisecond	Standard Deviation 3.331
RN6G 5 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QRS	-3.11 Millisecond	Standard Deviation 7.101
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QRS	-1.44 Millisecond	Standard Deviation 3.41
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QTcB	-14.78 Millisecond	Standard Deviation 38.322
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QT	-13.00 Millisecond	Standard Deviation 17.006
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QRS	0.22 Millisecond	Standard Deviation 5.054
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: RR	-39.89 Millisecond	Standard Deviation 85.486
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QRS	-0.11 Millisecond	Standard Deviation 6.217
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QT	-18.00 Millisecond	Standard Deviation 35.7
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QRS	1.56 Millisecond	Standard Deviation 4.593
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QRS	1.22 Millisecond	Standard Deviation 5.439
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QT	-6.00 Millisecond	Standard Deviation 14.092
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QRS	0.67 Millisecond	Standard Deviation 6.613
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QRS	-0.22 Millisecond	Standard Deviation 4.456
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: RR	-16.83 Millisecond	Standard Deviation 58.974
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QT	-9.33 Millisecond	Standard Deviation 17.42
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QRS	1.89 Millisecond	Standard Deviation 5.34
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QRS	0.22 Millisecond	Standard Deviation 3.569
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QTcB	3.17 Millisecond	Standard Deviation 11.201
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QRS	1.22 Millisecond	Standard Deviation 6.895
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QT	-11.33 Millisecond	Standard Deviation 13.914
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QT	422.00 Millisecond	Standard Deviation 29.835
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: RR	-66.17 Millisecond	Standard Deviation 86.676
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1H post-dose Day 1: QT	2.22 Millisecond	Standard Deviation 11.713
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QT	-8.67 Millisecond	Standard Deviation 10.302
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QT	-13.44 Millisecond	Standard Deviation 19.018
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QT	-11.33 Millisecond	Standard Deviation 17.42
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: RR	-31.78 Millisecond	Standard Deviation 27.507
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: RR	8.89 Millisecond	Standard Deviation 58.224
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: RR	-34.22 Millisecond	Standard Deviation 82.327
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QTcB	-4.33 Millisecond	Standard Deviation 8.899
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: RR	32.39 Millisecond	Standard Deviation 70.6
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: RR	962.44 Millisecond	Standard Deviation 117.246
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PR	190.00 Millisecond	Standard Deviation 38.006
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QTcB	1.33 Millisecond	Standard Deviation 13.471
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QTcB	-9.33 Millisecond	Standard Deviation 16.35
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: PR	-4.33 Millisecond	Standard Deviation 9.407
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: PR	-4.89 Millisecond	Standard Deviation 6.898
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: RR	0.39 Millisecond	Standard Deviation 53.575
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QTcB	-4.67 Millisecond	Standard Deviation 9.92
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: PR	1.00 Millisecond	Standard Deviation 10.673
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QTcB	-9.5 Millisecond	Standard Deviation 15.812
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QTcB	-12.50 Millisecond	Standard Deviation 14.442
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: PR	0.33 Millisecond	Standard Deviation 15.842
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: PR	-8.33 Millisecond	Standard Deviation 18.426
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QTcB	-6.67 Millisecond	Standard Deviation 14.188
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: PR	-3.33 Millisecond	Standard Deviation 18.086
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: RR	-19.78 Millisecond	Standard Deviation 32.654
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: PR	-1.11 Millisecond	Standard Deviation 14.052
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QTcB	-12.33 Millisecond	Standard Deviation 13.105
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QTcB	-3.50 Millisecond	Standard Deviation 6.483
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: PR	-1.56 Millisecond	Standard Deviation 11.938
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QTcB	1.83 Millisecond	Standard Deviation 9.697
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: PR	2.00 Millisecond	Standard Deviation 8.316
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QTcB	430.67 Millisecond	Standard Deviation 20.976
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PR	-7.00 Millisecond	Standard Deviation 12.994
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: RR	-12.78 Millisecond	Standard Deviation 56.646
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PR	-1.00 Millisecond	Standard Deviation 15.468
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QT	-1.67 Millisecond	Standard Deviation 16.896
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PR	-3.00 Millisecond	Standard Deviation 19.066
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QT	-9.67 Millisecond	Standard Deviation 12.442
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QRS	91.44 Millisecond	Standard Deviation 8.352
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QRS	-1.56 Millisecond	Standard Deviation 3.417
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: RR	-24.11 Millisecond	Standard Deviation 63.637
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QT	-5.67 Millisecond	Standard Deviation 11.939
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QRS	-1.67 Millisecond	Standard Deviation 2.692
RN6G 10 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: RR	24.94 Millisecond	Standard Deviation 70.632
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: RR	60.44 Millisecond	Standard Deviation 122.291
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: RR	918.39 Millisecond	Standard Deviation 101.325
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: RR	79.11 Millisecond	Standard Deviation 89.729
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: RR	22.33 Millisecond	Standard Deviation 115.576
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: RR	69.44 Millisecond	Standard Deviation 91.732
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: RR	74.78 Millisecond	Standard Deviation 98.804
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: RR	57.11 Millisecond	Standard Deviation 102.514
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: RR	34.94 Millisecond	Standard Deviation 77.744
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: RR	26.56 Millisecond	Standard Deviation 91.107
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: RR	80.44 Millisecond	Standard Deviation 104.487
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: RR	52.17 Millisecond	Standard Deviation 86.145
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: RR	-22.72 Millisecond	Standard Deviation 99.733
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: RR	-9.22 Millisecond	Standard Deviation 80.263
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PR	167.89 Millisecond	Standard Deviation 25.711
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: PR	-7.11 Millisecond	Standard Deviation 12.261
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: PR	-6.33 Millisecond	Standard Deviation 7.563
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: PR	28.44 Millisecond	Standard Deviation 84.486
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: PR	-11.47 Millisecond	Standard Deviation 22.912
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: PR	-0.67 Millisecond	Standard Deviation 1.944
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: PR	-13.56 Millisecond	Standard Deviation 22.134
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: PR	-4.22 Millisecond	Standard Deviation 5.311
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: PR	-4.67 Millisecond	Standard Deviation 14.569
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: PR	-7.89 Millisecond	Standard Deviation 11.262
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PR	-2.56 Millisecond	Standard Deviation 5.154
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PR	-7.89 Millisecond	Standard Deviation 7.061
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PR	-17.22 Millisecond	Standard Deviation 21.935
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QRS	97.89 Millisecond	Standard Deviation 22.444
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QRS	-2.33 Millisecond	Standard Deviation 2.789
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QRS	0.44 Millisecond	Standard Deviation 2.373
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QRS	-0.89 Millisecond	Standard Deviation 2.656
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QRS	1.78 Millisecond	Standard Deviation 2.722
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QRS	6.78 Millisecond	Standard Deviation 22.333
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QRS	5.11 Millisecond	Standard Deviation 20.149
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QRS	0.33 Millisecond	Standard Deviation 2.883
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QRS	1.22 Millisecond	Standard Deviation 2.083
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QRS	-0.44 Millisecond	Standard Deviation 1.44
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QRS	2.11 Millisecond	Standard Deviation 4.53
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QRS	9.78 Millisecond	Standard Deviation 26.712
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QRS	-2.56 Millisecond	Standard Deviation 1.76
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QT	408.56 Millisecond	Standard Deviation 30.56
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1H post-dose Day 1: QT	14.22 Millisecond	Standard Deviation 14.845
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QT	4.67 Millisecond	Standard Deviation 29.796
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QT	11.11 Millisecond	Standard Deviation 14.228
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QT	18.44 Millisecond	Standard Deviation 31.865
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QT	14.11 Millisecond	Standard Deviation 26.319
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QT	5.44 Millisecond	Standard Deviation 13.607
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QT	11.89 Millisecond	Standard Deviation 18.621
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QT	22.33 Millisecond	Standard Deviation 22.17
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QT	19.67 Millisecond	Standard Deviation 14.34
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QT	16.44 Millisecond	Standard Deviation 36.302
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QT	-1.22 Millisecond	Standard Deviation 27.995
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QT	-8.56 Millisecond	Standard Deviation 31.792
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QTcB	426.28 Millisecond	Standard Deviation 18.37
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QTcB	-2.67 Millisecond	Standard Deviation 12.006
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QTcB	-0.11 Millisecond	Standard Deviation 6.811
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QTcB	-2.94 Millisecond	Standard Deviation 18.639
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QTcB	1.56 Millisecond	Standard Deviation 15.45
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QTcB	2.22 Millisecond	Standard Deviation 21.281
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QTcB	-1.11 Millisecond	Standard Deviation 9.66
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QTcB	6.94 Millisecond	Standard Deviation 6.641
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QTcB	4.72 Millisecond	Standard Deviation 10.794
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QTcB	9.06 Millisecond	Standard Deviation 11.144
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QTcB	4.06 Millisecond	Standard Deviation 10.81
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QTcB	3.72 Millisecond	Standard Deviation 14.188
RN6G 15 mg/kg	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QTcB	-6.28 Millisecond	Standard Deviation 17.655
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QRS	-0.33 Millisecond	Standard Deviation 2.261
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QTcB	13.17 Millisecond	Standard Deviation 8.813
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QT	11.33 Millisecond	Standard Deviation 35.308
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QRS	0.78 Millisecond	Standard Deviation 3.41
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QRS	0.78 Millisecond	Standard Deviation 1.76
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QTcB	11.33 Millisecond	Standard Deviation 18.318
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QT	4.27 Millisecond	Standard Deviation 26.594
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QRS	100.33 Millisecond	Standard Deviation 24.858
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PR	16.33 Millisecond	Standard Deviation 21.709
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: RR	-51.67 Millisecond	Standard Deviation 186.668
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QT	19.22 Millisecond	Standard Deviation 22.225
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PR	14.13 Millisecond	Standard Deviation 24.214
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: RR	8.83 Millisecond	Standard Deviation 65.44
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QT	9.33 Millisecond	Standard Deviation 36.127
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PR	-1.50 Millisecond	Standard Deviation 10.932
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: PR	21.87 Millisecond	Standard Deviation 28.757
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QTcB	6.72 Millisecond	Standard Deviation 17.425
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QTcB	417.11 Millisecond	Standard Deviation 17.539
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: PR	16.27 Millisecond	Standard Deviation 22.229
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: PR	11.33 Millisecond	Standard Deviation 23.636
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QTcB	11.80 Millisecond	Standard Deviation 20.895
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QTcB	5.81 Millisecond	Standard Deviation 17.269
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: PR	16.53 Millisecond	Standard Deviation 26.764
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: PR	11.73 Millisecond	Standard Deviation 32.392
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: RR	49.00 Millisecond	Standard Deviation 78.316
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QTcB	13.50 Millisecond	Standard Deviation 29.257
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: PR	12.22 Millisecond	Standard Deviation 23.512
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QRS	0.00 Millisecond	Standard Deviation 4.922
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: RR	-54.11 Millisecond	Standard Deviation 94.978
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QTcB	-5.94 Millisecond	Standard Deviation 5.953
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: PR	3.89 Millisecond	Standard Deviation 12.245
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: PR	-2.89 Millisecond	Standard Deviation 6.362
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: RR	-28.67 Millisecond	Standard Deviation 70.982
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QTcB	5.39 Millisecond	Standard Deviation 19.841
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: PR	-2.67 Millisecond	Standard Deviation 6.902
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PR	166.11 Millisecond	Standard Deviation 41.177
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QTcB	10.07 Millisecond	Standard Deviation 21.177
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QTcB	23.07 Millisecond	Standard Deviation 32.116
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: RR	-11.92 Millisecond	Standard Deviation 122.446
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: RR	56.50 Millisecond	Standard Deviation 78.87
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: RR	-21.22 Millisecond	Standard Deviation 136.555
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QTcB	29.07 Millisecond	Standard Deviation 42.361
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: RR	5.13 Millisecond	Standard Deviation 166.054
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QT	4.89 Millisecond	Standard Deviation 18.29
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QT	1.56 Millisecond	Standard Deviation 32.457
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1H post-dose Day 1: QT	0.78 Millisecond	Standard Deviation 26.346
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: RR	42.60 Millisecond	Standard Deviation 150.052
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QT	8.22 Millisecond	Standard Deviation 10.221
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QT	401.78 Millisecond	Standard Deviation 31.932
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QRS	5.83 Millisecond	Standard Deviation 4.631
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: RR	928.33 Millisecond	Standard Deviation 117.701
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QT	10.27 Millisecond	Standard Deviation 28.482
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QRS	1.00 Millisecond	Standard Deviation 2.692
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QRS	2.53 Millisecond	Standard Deviation 5.586
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QTcB	9.33 Millisecond	Standard Deviation 22.955
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QT	19.07 Millisecond	Standard Deviation 35.345
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QRS	0.40 Millisecond	Standard Deviation 4.681
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QRS	-0.40 Millisecond	Standard Deviation 4.017
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: RR	-9.60 Millisecond	Standard Deviation 51.462
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QT	7.47 Millisecond	Standard Deviation 25.304
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QRS	0.80 Millisecond	Standard Deviation 4.84
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QRS	1.60 Millisecond	Standard Deviation 9.541
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: RR	-44.87 Millisecond	Standard Deviation 82.091
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QT	19.33 Millisecond	Standard Deviation 28.091
Placebo	Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QRS	-2.67 Millisecond	Standard Deviation 6.037

Secondary

Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Following parameters were analyzed for laboratory examination: Bilirubin, Direct Bilirubin, Blood Urea Nitrogen(BUN), Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol (CL)(Fasting), Triglycerides (Fasting) (TG), Immunoglobulin G (Ig G), Immunoglobulin A (Ig A), Immunoglobulin M (Ig M)

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Population: All randomized participants who met the inclusion criteria and received any amount of study drug were included. Here Number Analyzed signifies number of participants evaluated for given time point. Categories with at least 1 non-zero data have been provided below.

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Bilirubin	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.075
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Calcium	0.17 Milligram per deciliter (MG/DL)	Standard Deviation 0.55
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Creatinine	0.008 Milligram per deciliter (MG/DL)	Standard Deviation 0.1121
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Calcium	0.13 Milligram per deciliter (MG/DL)	Standard Deviation 0.367
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Bilirubin	-0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.082
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Creatinine	0.020 Milligram per deciliter (MG/DL)	Standard Deviation 0.1316
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Calcium	-0.15 Milligram per deciliter (MG/DL)	Standard Deviation 0.638
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Glucose	22.8 Milligram per deciliter (MG/DL)	Standard Deviation 48.16
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Calcium	0.10 Milligram per deciliter (MG/DL)	Standard Deviation 0.369
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: TG (fasting)	-15.0 Milligram per deciliter (MG/DL)	Standard Deviation 45.79
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: TG (fasting)	4.2 Milligram per deciliter (MG/DL)	Standard Deviation 63.29
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Direct Bilirubin	0.15 Milligram per deciliter (MG/DL)	Standard Deviation 0.055
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Uric Acid	-0.05 Milligram per deciliter (MG/DL)	Standard Deviation 0.497
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Creatinine	0.053 Milligram per deciliter (MG/DL)	Standard Deviation 0.0755
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Glucose	93.8 Milligram per deciliter (MG/DL)	Standard Deviation 11.2
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Direct Bilirubin	-0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.052
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Phosphate	0.22 Milligram per deciliter (MG/DL)	Standard Deviation 0.417
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: CL (fasting)	-6.5 Milligram per deciliter (MG/DL)	Standard Deviation 35.23
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Uric Acid	0.62 Milligram per deciliter (MG/DL)	Standard Deviation 1.072
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.063
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Uric Acid	-0.08 Milligram per deciliter (MG/DL)	Standard Deviation 0.722
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: CL (fasting)	-9.0 Milligram per deciliter (MG/DL)	Standard Deviation 13.28
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Creatinine	-0.002 Milligram per deciliter (MG/DL)	Standard Deviation 0.1321
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.063
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Creatinine	0.918 Milligram per deciliter (MG/DL)	Standard Deviation 0.2322
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: TG (fasting)	-11.5 Milligram per deciliter (MG/DL)	Standard Deviation 43.72
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Phosphate	0.13 Milligram per deciliter (MG/DL)	Standard Deviation 0.472
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Direct Bilirubin	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.075
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: CL (fasting)	-2.5 Milligram per deciliter (MG/DL)	Standard Deviation 17.13
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Uric Acid	-0.32 Milligram per deciliter (MG/DL)	Standard Deviation 0.571
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Glucose	0.7 Milligram per deciliter (MG/DL)	Standard Deviation 6.28
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Direct Bilirubin	-0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.052
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Bilirubin	0.48 Milligram per deciliter (MG/DL)	Standard Deviation 0.147
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: TG (fasting)	141.7 Milligram per deciliter (MG/DL)	Standard Deviation 47.32
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Phosphate	0.17 Milligram per deciliter (MG/DL)	Standard Deviation 0.459
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Direct Bilirubin	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.041
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Uric Acid	0.23 Milligram per deciliter (MG/DL)	Standard Deviation 0.855
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Uric Acid	-0.05 Milligram per deciliter (MG/DL)	Standard Deviation 0.641
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Creatinine	0.043 Milligram per deciliter (MG/DL)	Standard Deviation 0.1179
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Direct Bilirubin	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.075
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Creatinine	0.047 Milligram per deciliter (MG/DL)	Standard Deviation 0.088
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: TG (fasting)	-24.5 Milligram per deciliter (MG/DL)	Standard Deviation 46
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Phosphate	0.32 Milligram per deciliter (MG/DL)	Standard Deviation 0.36
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: TG (fasting)	2.2 Milligram per deciliter (MG/DL)	Standard Deviation 38.57
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Calcium	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.335
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Bilirubin	-0.05 Milligram per deciliter (MG/DL)	Standard Deviation 0.122
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: BUN	18.7 Milligram per deciliter (MG/DL)	Standard Deviation 5.01
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Uric Acid	4.87 Milligram per deciliter (MG/DL)	Standard Deviation 1.172
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: CL (fasting)	0.0 Milligram per deciliter (MG/DL)	Standard Deviation 8.02
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Phosphate	0.27 Milligram per deciliter (MG/DL)	Standard Deviation 0.308
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: BUN	-0.3 Milligram per deciliter (MG/DL)	Standard Deviation 3.14
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Glucose	4.7 Milligram per deciliter (MG/DL)	Standard Deviation 5.28
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: CL (fasting)	191.7 Milligram per deciliter (MG/DL)	Standard Deviation 20.34
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Bilirubin	0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.133
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: BUN	-2.0 Milligram per deciliter (MG/DL)	Standard Deviation 2.1
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: CL (fasting)	-4.7 Milligram per deciliter (MG/DL)	Standard Deviation 19.79
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Creatinine	0.055 Milligram per deciliter (MG/DL)	Standard Deviation 0.171
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Phosphate	0.27 Milligram per deciliter (MG/DL)	Standard Deviation 0.489
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: BUN	1.3 Milligram per deciliter (MG/DL)	Standard Deviation 4.32
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Uric Acid	-0.05 Milligram per deciliter (MG/DL)	Standard Deviation 0.539
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: CL (fasting)	-0.8 Milligram per deciliter (MG/DL)	Standard Deviation 26.54
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Bilirubin	-0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.082
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: BUN	-0.2 Milligram per deciliter (MG/DL)	Standard Deviation 5.08
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Calcium	0.12 Milligram per deciliter (MG/DL)	Standard Deviation 0.279
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: CL (fasting)	12.3 Milligram per deciliter (MG/DL)	Standard Deviation 14.19
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Phosphate	-0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.273
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: BUN	1.0 Milligram per deciliter (MG/DL)	Standard Deviation 4.6
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Glucose	-2.0 Milligram per deciliter (MG/DL)	Standard Deviation 1.41
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Bilirubin	-0.10 Milligram per deciliter (MG/DL)	Standard Deviation 0.141
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Glucose	6.8 Milligram per deciliter (MG/DL)	Standard Deviation 4.88
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: BUN	0.0 Milligram per deciliter (MG/DL)	Standard Deviation 2.45
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: TG (fasting)	6.0 Milligram per deciliter (MG/DL)	Standard Deviation 73.16
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Calcium	9.62 Milligram per deciliter (MG/DL)	Standard Deviation 0.248
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Phosphate	3.20 Milligram per deciliter (MG/DL)	Standard Deviation 0.583
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: BUN	1.2 Milligram per deciliter (MG/DL)	Standard Deviation 2.14
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Bilirubin	-0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.082
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: TG (fasting)	-23.2 Milligram per deciliter (MG/DL)	Standard Deviation 35.44
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Calcium	-0.17 Milligram per deciliter (MG/DL)	Standard Deviation 0.361
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Glucose	-1.0 Milligram per deciliter (MG/DL)	Standard Deviation 6.42
RN6G 5 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Glucose	1.7 Milligram per deciliter (MG/DL)	Standard Deviation 6.19
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Glucose	5.8 Milligram per deciliter (MG/DL)	Standard Deviation 12.16
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: BUN	-0.2 Milligram per deciliter (MG/DL)	Standard Deviation 4.07
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: CL (fasting)	1.5 Milligram per deciliter (MG/DL)	Standard Deviation 9.57
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Phosphate	3.48 Milligram per deciliter (MG/DL)	Standard Deviation 0.376
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: BUN	0.5 Milligram per deciliter (MG/DL)	Standard Deviation 3.51
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Glucose	3.3 Milligram per deciliter (MG/DL)	Standard Deviation 5.85
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: BUN	1.3 Milligram per deciliter (MG/DL)	Standard Deviation 2.8
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Calcium	-0.15 Milligram per deciliter (MG/DL)	Standard Deviation 0.446
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: BUN	1.5 Milligram per deciliter (MG/DL)	Standard Deviation 2.59
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Calcium	-0.27 Milligram per deciliter (MG/DL)	Standard Deviation 0.393
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: TG (fasting)	4.0 Milligram per deciliter (MG/DL)	Standard Deviation 68.07
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Creatinine	0.955 Milligram per deciliter (MG/DL)	Standard Deviation 0.075
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Creatinine	-0.032 Milligram per deciliter (MG/DL)	Standard Deviation 0.0708
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Calcium	-0.32 Milligram per deciliter (MG/DL)	Standard Deviation 0.306
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Creatinine	0.000 Milligram per deciliter (MG/DL)	Standard Deviation 0.1163
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Glucose	3.2 Milligram per deciliter (MG/DL)	Standard Deviation 6.11
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Creatinine	0.038 Milligram per deciliter (MG/DL)	Standard Deviation 0.1196
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Calcium	-0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.388
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: CL (fasting)	0.2 Milligram per deciliter (MG/DL)	Standard Deviation 10.72
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Creatinine	0.008 Milligram per deciliter (MG/DL)	Standard Deviation 0.0924
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Creatinine	-0.020 Milligram per deciliter (MG/DL)	Standard Deviation 0.1271
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: CL (fasting)	-2.5 Milligram per deciliter (MG/DL)	Standard Deviation 8.57
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Creatinine	-0.045 Milligram per deciliter (MG/DL)	Standard Deviation 0.0922
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Calcium	-0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.344
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Creatinine	0.012 Milligram per deciliter (MG/DL)	Standard Deviation 0.1297
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: TG (fasting)	-24.7 Milligram per deciliter (MG/DL)	Standard Deviation 57.41
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Calcium	-0.22 Milligram per deciliter (MG/DL)	Standard Deviation 0.264
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Creatinine	0.008 Milligram per deciliter (MG/DL)	Standard Deviation 0.1072
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Glucose	6.3 Milligram per deciliter (MG/DL)	Standard Deviation 12.04
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Uric Acid	5.97 Milligram per deciliter (MG/DL)	Standard Deviation 1.335
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: CL (fasting)	-5.8 Milligram per deciliter (MG/DL)	Standard Deviation 7.99
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Calcium	9.62 Milligram per deciliter (MG/DL)	Standard Deviation 0.458
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Uric Acid	-0.25 Milligram per deciliter (MG/DL)	Standard Deviation 0.176
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Calcium	-0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.356
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Uric Acid	0.32 Milligram per deciliter (MG/DL)	Standard Deviation 0.677
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Calcium	-0.17 Milligram per deciliter (MG/DL)	Standard Deviation 0.378
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: CL (fasting)	-10.2 Milligram per deciliter (MG/DL)	Standard Deviation 15.79
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Uric Acid	0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.662
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Uric Acid	-0.25 Milligram per deciliter (MG/DL)	Standard Deviation 0.383
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Uric Acid	0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.327
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Phosphate	0.08 Milligram per deciliter (MG/DL)	Standard Deviation 0.382
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Uric Acid	-0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.698
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Uric Acid	0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.694
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Uric Acid	-0.05 Milligram per deciliter (MG/DL)	Standard Deviation 0.701
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Bilirubin	0.58 Milligram per deciliter (MG/DL)	Standard Deviation 0.422
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Glucose	7.3 Milligram per deciliter (MG/DL)	Standard Deviation 12.13
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Bilirubin	-0.12 Milligram per deciliter (MG/DL)	Standard Deviation 0.264
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: TG (fasting)	-18.0 Milligram per deciliter (MG/DL)	Standard Deviation 43.32
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Bilirubin	-0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.121
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: CL (fasting)	1.3 Milligram per deciliter (MG/DL)	Standard Deviation 19.28
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Glucose	7.2 Milligram per deciliter (MG/DL)	Standard Deviation 12.56
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Bilirubin	-0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.25
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Bilirubin	-0.08 Milligram per deciliter (MG/DL)	Standard Deviation 0.325
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Glucose	3.7 Milligram per deciliter (MG/DL)	Standard Deviation 7.42
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Bilirubin	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.343
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: TG (fasting)	-16.5 Milligram per deciliter (MG/DL)	Standard Deviation 32.31
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.2
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: CL (fasting)	0.3 Milligram per deciliter (MG/DL)	Standard Deviation 15.23
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Glucose	3.8 Milligram per deciliter (MG/DL)	Standard Deviation 9.77
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.21
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: CL (fasting)	2.7 Milligram per deciliter (MG/DL)	Standard Deviation 15.12
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Bilirubin	0.05 Milligram per deciliter (MG/DL)	Standard Deviation 0.105
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Glucose	92.5 Milligram per deciliter (MG/DL)	Standard Deviation 7.84
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Direct Bilirubin	0.17 Milligram per deciliter (MG/DL)	Standard Deviation 0.082
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: TG (fasting)	-13.7 Milligram per deciliter (MG/DL)	Standard Deviation 50.39
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Direct Bilirubin	-0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.052
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Phosphate	0.25 Milligram per deciliter (MG/DL)	Standard Deviation 0.217
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Phosphate	-0.10 Milligram per deciliter (MG/DL)	Standard Deviation 0.456
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Direct Bilirubin	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.041
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Direct Bilirubin	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.041
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: TG (fasting)	-7.3 Milligram per deciliter (MG/DL)	Standard Deviation 26.3
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Phosphate	-0.12 Milligram per deciliter (MG/DL)	Standard Deviation 0.331
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Direct Bilirubin	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.041
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Direct Bilirubin	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.041
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: CL (fasting)	188.7 Milligram per deciliter (MG/DL)	Standard Deviation 60.01
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Phosphate	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.369
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: TG (fasting)	-18.0 Milligram per deciliter (MG/DL)	Standard Deviation 54.98
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Phosphate	0.17 Milligram per deciliter (MG/DL)	Standard Deviation 0.197
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: BUN	15.5 Milligram per deciliter (MG/DL)	Standard Deviation 3.89
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: TG (fasting)	138.5 Milligram per deciliter (MG/DL)	Standard Deviation 58.95
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: BUN	-0.2 Milligram per deciliter (MG/DL)	Standard Deviation 2.64
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Phosphate	0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.197
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: BUN	-1.2 Milligram per deciliter (MG/DL)	Standard Deviation 4.62
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: TG (fasting)	-18.5 Milligram per deciliter (MG/DL)	Standard Deviation 31.17
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: BUN	1.3 Milligram per deciliter (MG/DL)	Standard Deviation 3.78
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Phosphate	0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.194
RN6G 10 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: BUN	-0.5 Milligram per deciliter (MG/DL)	Standard Deviation 2.74
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Creatinine	0.042 Milligram per deciliter (MG/DL)	Standard Deviation 0.0891
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: lg M	101.0 Milligram per deciliter (MG/DL)	Standard Deviation 60.79
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: lg M	9.7 Milligram per deciliter (MG/DL)	Standard Deviation 8.74
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: lg M	4.7 Milligram per deciliter (MG/DL)	Standard Deviation 7.06
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: lg M	8.2 Milligram per deciliter (MG/DL)	Standard Deviation 19.69
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: CL (fasting)	-3.5 Milligram per deciliter (MG/DL)	Standard Deviation 13.88
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: TG (fasting)	110.5 Milligram per deciliter (MG/DL)	Standard Deviation 41.4
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: TG (fasting)	-9.3 Milligram per deciliter (MG/DL)	Standard Deviation 34.91
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: TG (fasting)	-8.2 Milligram per deciliter (MG/DL)	Standard Deviation 23.51
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: TG (fasting)	-19.7 Milligram per deciliter (MG/DL)	Standard Deviation 18.22
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: TG (fasting)	-2.8 Milligram per deciliter (MG/DL)	Standard Deviation 23.76
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: TG (fasting)	-7.5 Milligram per deciliter (MG/DL)	Standard Deviation 29.13
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: TG (fasting)	-4.2 Milligram per deciliter (MG/DL)	Standard Deviation 24.13
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: TG (fasting)	-13.8 Milligram per deciliter (MG/DL)	Standard Deviation 22.68
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: TG (fasting)	0.5 Milligram per deciliter (MG/DL)	Standard Deviation 26.94
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: lg G	840.5 Milligram per deciliter (MG/DL)	Standard Deviation 171.08
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: lg G	42.7 Milligram per deciliter (MG/DL)	Standard Deviation 26.63
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: lg G	69.7 Milligram per deciliter (MG/DL)	Standard Deviation 65.83
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: lg G	41.8 Milligram per deciliter (MG/DL)	Standard Deviation 72.02
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: lg A	257.3 Milligram per deciliter (MG/DL)	Standard Deviation 108.27
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: lg A	7.0 Milligram per deciliter (MG/DL)	Standard Deviation 7.55
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: lg A	-10.0 Milligram per deciliter (MG/DL)	Standard Deviation 14.56
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: lg A	-4.2 Milligram per deciliter (MG/DL)	Standard Deviation 26.36
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Calcium	0.10 Milligram per deciliter (MG/DL)	Standard Deviation 0.54
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Bilirubin	0.47 Milligram per deciliter (MG/DL)	Standard Deviation 0.234
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Bilirubin	0.08 Milligram per deciliter (MG/DL)	Standard Deviation 0.435
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Bilirubin	0.25 Milligram per deciliter (MG/DL)	Standard Deviation 0.409
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Bilirubin	0.12 Milligram per deciliter (MG/DL)	Standard Deviation 0.133
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Bilirubin	0.20 Milligram per deciliter (MG/DL)	Standard Deviation 0.276
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Bilirubin	0.20 Milligram per deciliter (MG/DL)	Standard Deviation 0.316
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Bilirubin	0.17 Milligram per deciliter (MG/DL)	Standard Deviation 0.423
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Bilirubin	0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.133
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Bilirubin	0.20 Milligram per deciliter (MG/DL)	Standard Deviation 0.415
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Direct Bilirubin	0.15 Milligram per deciliter (MG/DL)	Standard Deviation 0.055
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.082
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Direct Bilirubin	0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.098
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.063
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.071
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.063
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Direct Bilirubin	0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.098
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Direct Bilirubin	0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.098
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: BUN	18.8 Milligram per deciliter (MG/DL)	Standard Deviation 3.87
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: BUN	0.5 Milligram per deciliter (MG/DL)	Standard Deviation 7.14
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: BUN	2.7 Milligram per deciliter (MG/DL)	Standard Deviation 1.63
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: BUN	-0.2 Milligram per deciliter (MG/DL)	Standard Deviation 5.98
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: BUN	1.7 Milligram per deciliter (MG/DL)	Standard Deviation 4.27
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: BUN	1.3 Milligram per deciliter (MG/DL)	Standard Deviation 2.42
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: BUN	1.0 Milligram per deciliter (MG/DL)	Standard Deviation 3.46
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: BUN	0.8 Milligram per deciliter (MG/DL)	Standard Deviation 2.93
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: BUN	2.3 Milligram per deciliter (MG/DL)	Standard Deviation 4.63
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Creatinine	0.917 Milligram per deciliter (MG/DL)	Standard Deviation 0.1657
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Creatinine	0.108 Milligram per deciliter (MG/DL)	Standard Deviation 0.1024
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Creatinine	0.037 Milligram per deciliter (MG/DL)	Standard Deviation 0.0766
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Creatinine	0.082 Milligram per deciliter (MG/DL)	Standard Deviation 0.1389
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Creatinine	0.035 Milligram per deciliter (MG/DL)	Standard Deviation 0.0742
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Creatinine	0.113 Milligram per deciliter (MG/DL)	Standard Deviation 0.1088
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Creatinine	0.047 Milligram per deciliter (MG/DL)	Standard Deviation 0.1196
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Creatinine	0.092 Milligram per deciliter (MG/DL)	Standard Deviation 0.0909
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Uric Acid	5.77 Milligram per deciliter (MG/DL)	Standard Deviation 1.039
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Calcium	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.387
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Calcium	0.08 Milligram per deciliter (MG/DL)	Standard Deviation 0.488
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Calcium	-0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.472
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Uric Acid	0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.64
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Uric Acid	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.566
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Uric Acid	-0.12 Milligram per deciliter (MG/DL)	Standard Deviation 0.943
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Uric Acid	0.32 Milligram per deciliter (MG/DL)	Standard Deviation 0.804
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Uric Acid	0.18 Milligram per deciliter (MG/DL)	Standard Deviation 0.828
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Uric Acid	0.28 Milligram per deciliter (MG/DL)	Standard Deviation 0.422
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Uric Acid	0.17 Milligram per deciliter (MG/DL)	Standard Deviation 0.836
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Uric Acid	-0.07 Milligram per deciliter (MG/DL)	Standard Deviation 1.143
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Calcium	9.60 Milligram per deciliter (MG/DL)	Standard Deviation 0.358
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Calcium	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.395
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: CL (fasting)	-12.5 Milligram per deciliter (MG/DL)	Standard Deviation 21.68
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: CL (fasting)	-11.8 Milligram per deciliter (MG/DL)	Standard Deviation 24.34
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Calcium	-0.17 Milligram per deciliter (MG/DL)	Standard Deviation 0.327
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Calcium	0.05 Milligram per deciliter (MG/DL)	Standard Deviation 0.509
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Calcium	0.23 Milligram per deciliter (MG/DL)	Standard Deviation 0.484
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Phosphate	3.62 Milligram per deciliter (MG/DL)	Standard Deviation 0.637
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Phosphate	0.18 Milligram per deciliter (MG/DL)	Standard Deviation 0.31
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Phosphate	0.25 Milligram per deciliter (MG/DL)	Standard Deviation 0.539
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Phosphate	0.12 Milligram per deciliter (MG/DL)	Standard Deviation 0.512
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Phosphate	0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.356
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Phosphate	-0.27 Milligram per deciliter (MG/DL)	Standard Deviation 0.575
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Phosphate	0.15 Milligram per deciliter (MG/DL)	Standard Deviation 0.418
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Phosphate	0.15 Milligram per deciliter (MG/DL)	Standard Deviation 0.521
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Phosphate	0.12 Milligram per deciliter (MG/DL)	Standard Deviation 0.598
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Glucose	90.0 Milligram per deciliter (MG/DL)	Standard Deviation 13.97
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Glucose	7.0 Milligram per deciliter (MG/DL)	Standard Deviation 5.48
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Glucose	6.5 Milligram per deciliter (MG/DL)	Standard Deviation 15.67
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Glucose	7.5 Milligram per deciliter (MG/DL)	Standard Deviation 11.47
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Glucose	9.2 Milligram per deciliter (MG/DL)	Standard Deviation 11.58
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Glucose	17.7 Milligram per deciliter (MG/DL)	Standard Deviation 7.69
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Glucose	12.5 Milligram per deciliter (MG/DL)	Standard Deviation 14.79
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Glucose	8.5 Milligram per deciliter (MG/DL)	Standard Deviation 12.85
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Glucose	3.8 Milligram per deciliter (MG/DL)	Standard Deviation 15.69
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: CL (fasting)	196.5 Milligram per deciliter (MG/DL)	Standard Deviation 48.19
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: CL (fasting)	-10.8 Milligram per deciliter (MG/DL)	Standard Deviation 12.63
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: CL (fasting)	1.7 Milligram per deciliter (MG/DL)	Standard Deviation 12.89
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: CL (fasting)	-2.2 Milligram per deciliter (MG/DL)	Standard Deviation 10.8
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: CL (fasting)	0.7 Milligram per deciliter (MG/DL)	Standard Deviation 19.05
RN6G 15 mg/kg	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: CL (fasting)	4.2 Milligram per deciliter (MG/DL)	Standard Deviation 10.67
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: BUN	-3.5 Milligram per deciliter (MG/DL)	Standard Deviation 6.35
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Glucose	20.3 Milligram per deciliter (MG/DL)	Standard Deviation 50.7
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Calcium	-0.08 Milligram per deciliter (MG/DL)	Standard Deviation 0.512
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: BUN	-0.5 Milligram per deciliter (MG/DL)	Standard Deviation 8.87
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: TG (fasting)	-58.0 Milligram per deciliter (MG/DL)	Standard Deviation 77.36
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Calcium	0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.377
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: BUN	-1.2 Milligram per deciliter (MG/DL)	Standard Deviation 6.76
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: BUN	-1.6 Milligram per deciliter (MG/DL)	Standard Deviation 5.41
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: TG (fasting)	-52.2 Milligram per deciliter (MG/DL)	Standard Deviation 151.28
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Phosphate	3.28 Milligram per deciliter (MG/DL)	Standard Deviation 0.717
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: CL (fasting)	-7.2 Milligram per deciliter (MG/DL)	Standard Deviation 18.86
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Phosphate	0.22 Milligram per deciliter (MG/DL)	Standard Deviation 0.508
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: BUN	-1.0 Milligram per deciliter (MG/DL)	Standard Deviation 7.62
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: BUN	-3.6 Milligram per deciliter (MG/DL)	Standard Deviation 7.02
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: CL (fasting)	194.2 Milligram per deciliter (MG/DL)	Standard Deviation 33.71
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Phosphate	0.22 Milligram per deciliter (MG/DL)	Standard Deviation 0.598
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: BUN	0.0 Milligram per deciliter (MG/DL)	Standard Deviation 4.52
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: BUN	1.5 Milligram per deciliter (MG/DL)	Standard Deviation 3.73
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: TG (fasting)	-67.6 Milligram per deciliter (MG/DL)	Standard Deviation 84.14
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Phosphate	0.12 Milligram per deciliter (MG/DL)	Standard Deviation 0.466
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: BUN	23.3 Milligram per deciliter (MG/DL)	Standard Deviation 8.33
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Direct Bilirubin	0.03 Milligram per deciliter (MG/DL)	Standard Deviation 0.05
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: TG (fasting)	-89.0 Milligram per deciliter (MG/DL)	Standard Deviation 146.53
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Phosphate	0.38 Milligram per deciliter (MG/DL)	Standard Deviation 0.497
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.063
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Direct Bilirubin	0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.045
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: lg M	-9.0 Milligram per deciliter (MG/DL)	—
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Phosphate	0.58 Milligram per deciliter (MG/DL)	Standard Deviation 0.554
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Direct Bilirubin	0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.045
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: CL (fasting)	13.3 Milligram per deciliter (MG/DL)	Standard Deviation 27.09
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Phosphate	0.36 Milligram per deciliter (MG/DL)	Standard Deviation 0.581
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Direct Bilirubin	0.00 Milligram per deciliter (MG/DL)	Standard Deviation 0.071
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: TG (fasting)	-98.4 Milligram per deciliter (MG/DL)	Standard Deviation 140.73
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Phosphate	0.30 Milligram per deciliter (MG/DL)	Standard Deviation 0.863
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Direct Bilirubin	-0.02 Milligram per deciliter (MG/DL)	Standard Deviation 0.041
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: TG (fasting)	-49.5 Milligram per deciliter (MG/DL)	Standard Deviation 124.64
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Phosphate	0.15 Milligram per deciliter (MG/DL)	Standard Deviation 0.412
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Direct Bilirubin	0.13 Milligram per deciliter (MG/DL)	Standard Deviation 0.052
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Bilirubin	-0.05 Milligram per deciliter (MG/DL)	Standard Deviation 0.1
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: lg M	-6.0 Milligram per deciliter (MG/DL)	—
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Glucose	95.8 Milligram per deciliter (MG/DL)	Standard Deviation 9.99
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Bilirubin	-0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.163
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Bilirubin	-0.08 Milligram per deciliter (MG/DL)	Standard Deviation 0.192
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: CL (fasting)	8.0 Milligram per deciliter (MG/DL)	Standard Deviation 42.82
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Glucose	3.3 Milligram per deciliter (MG/DL)	Standard Deviation 14.39
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Bilirubin	-0.10 Milligram per deciliter (MG/DL)	Standard Deviation 0.158
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Bilirubin	-0.10 Milligram per deciliter (MG/DL)	Standard Deviation 0.158
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: TG (fasting)	-8.0 Milligram per deciliter (MG/DL)	Standard Deviation 37.31
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Glucose	0.5 Milligram per deciliter (MG/DL)	Standard Deviation 11.04
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Bilirubin	-0.10 Milligram per deciliter (MG/DL)	Standard Deviation 0.122
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Bilirubin	-0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.121
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: TG (fasting)	195.2 Milligram per deciliter (MG/DL)	Standard Deviation 149.85
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Glucose	7.8 Milligram per deciliter (MG/DL)	Standard Deviation 13.35
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Bilirubin	-0.10 Milligram per deciliter (MG/DL)	Standard Deviation 0.126
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Bilirubin	0.52 Milligram per deciliter (MG/DL)	Standard Deviation 0.204
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: lg M	58.0 Milligram per deciliter (MG/DL)	—
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Glucose	3.6 Milligram per deciliter (MG/DL)	Standard Deviation 10.67
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Calcium	-0.37 Milligram per deciliter (MG/DL)	Standard Deviation 0.301
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: lg A	-25.0 Milligram per deciliter (MG/DL)	—
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: CL (fasting)	-2.4 Milligram per deciliter (MG/DL)	Standard Deviation 23.2
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Glucose	11.0 Milligram per deciliter (MG/DL)	Standard Deviation 14.61
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: lg A	299.0 Milligram per deciliter (MG/DL)	—
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: lg G	-40.0 Milligram per deciliter (MG/DL)	—
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Uric Acid	0.32 Milligram per deciliter (MG/DL)	Standard Deviation 0.785
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Uric Acid	0.10 Milligram per deciliter (MG/DL)	Standard Deviation 0.997
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Uric Acid	-0.48 Milligram per deciliter (MG/DL)	Standard Deviation 0.487
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: CL (fasting)	-1.3 Milligram per deciliter (MG/DL)	Standard Deviation 29.34
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Uric Acid	0.22 Milligram per deciliter (MG/DL)	Standard Deviation 0.779
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Uric Acid	-0.07 Milligram per deciliter (MG/DL)	Standard Deviation 0.463
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Uric Acid	0.22 Milligram per deciliter (MG/DL)	Standard Deviation 0.471
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Glucose	17.6 Milligram per deciliter (MG/DL)	Standard Deviation 32.65
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Uric Acid	0.48 Milligram per deciliter (MG/DL)	Standard Deviation 0.933
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Calcium	-0.26 Milligram per deciliter (MG/DL)	Standard Deviation 0.55
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: lg G	-30.0 Milligram per deciliter (MG/DL)	—
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Uric Acid	-0.10 Milligram per deciliter (MG/DL)	Standard Deviation 0.51
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Calcium	-0.38 Milligram per deciliter (MG/DL)	Standard Deviation 0.396
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Uric Acid	5.58 Milligram per deciliter (MG/DL)	Standard Deviation 1.238
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: lg G	793.0 Milligram per deciliter (MG/DL)	—
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Calcium	9.76 Milligram per deciliter (MG/DL)	Standard Deviation 0.301
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Creatinine	-0.045 Milligram per deciliter (MG/DL)	Standard Deviation 0.3023
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Creatinine	0.015 Milligram per deciliter (MG/DL)	Standard Deviation 0.2118
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: CL (fasting)	7.2 Milligram per deciliter (MG/DL)	Standard Deviation 40.49
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Creatinine	-0.018 Milligram per deciliter (MG/DL)	Standard Deviation 0.2525
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Calcium	-0.22 Milligram per deciliter (MG/DL)	Standard Deviation 0.471
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Creatinine	0.002 Milligram per deciliter (MG/DL)	Standard Deviation 0.1956
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Glucose	7.2 Milligram per deciliter (MG/DL)	Standard Deviation 28.03
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: CL (fasting)	13.0 Milligram per deciliter (MG/DL)	Standard Deviation 37.9
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Creatinine	-0.024 Milligram per deciliter (MG/DL)	Standard Deviation 0.1747
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Creatinine	-0.038 Milligram per deciliter (MG/DL)	Standard Deviation 0.1512
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: TG (fasting)	-42.0 Milligram per deciliter (MG/DL)	Standard Deviation 168.16
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: lg A	-25.0 Milligram per deciliter (MG/DL)	—
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Calcium	-0.16 Milligram per deciliter (MG/DL)	Standard Deviation 0.498
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Creatinine	-0.013 Milligram per deciliter (MG/DL)	Standard Deviation 0.1317
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Creatinine	-0.007 Milligram per deciliter (MG/DL)	Standard Deviation 0.1371
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: CL (fasting)	-5.4 Milligram per deciliter (MG/DL)	Standard Deviation 33.06
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Calcium	-0.30 Milligram per deciliter (MG/DL)	Standard Deviation 0.66
Placebo	Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Creatinine	1.105 Milligram per deciliter (MG/DL)	Standard Deviation 0.3136

Secondary

Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET

Time frame: Baseline, 1 and 4 H post-dose on Day 1; pre-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 168, 224 and 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112	-1.78 Beats per minute	Standard Deviation 1.559
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140	0.50 Beats per minute	Standard Deviation 2.606
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1	2.28 Beats per minute	Standard Deviation 2.752
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140	3.67 Beats per minute	Standard Deviation 5.578
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140	2.61 Beats per minute	Standard Deviation 11.432
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET	-0.61 Beats per minute	Standard Deviation 5.031
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28	-1.78 Beats per minute	Standard Deviation 2.562
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1	-0.33 Beats per minute	Standard Deviation 3.026
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56	0.39 Beats per minute	Standard Deviation 4.096
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168	2.22 Beats per minute	Standard Deviation 5.419
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84	0.22 Beats per minute	Standard Deviation 3.41
RN6G 5 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline	64.94 Beats per minute	Standard Deviation 9.318
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline	63.17 Beats per minute	Standard Deviation 7.327
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28	-0.17 Beats per minute	Standard Deviation 3.475
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET	-0.67 Beats per minute	Standard Deviation 4.279
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140	5.11 Beats per minute	Standard Deviation 6.869
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112	1.33 Beats per minute	Standard Deviation 4.58
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140	2.89 Beats per minute	Standard Deviation 5.556
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168	2.00 Beats per minute	Standard Deviation 1.687
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84	0.50 Beats per minute	Standard Deviation 3.378
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56	1.17 Beats per minute	Standard Deviation 1.81
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140	1.17 Beats per minute	Standard Deviation 3.65
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1	2.11 Beats per minute	Standard Deviation 5.188
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET	-2.50 Beats per minute	Standard Deviation 4.451
RN6G 10 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1	-1.67 Beats per minute	Standard Deviation 4.142
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140	-3.61 Beats per minute	Standard Deviation 5.752
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline	66.06 Beats per minute	Standard Deviation 7.295
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1	-5.44 Beats per minute	Standard Deviation 6.527
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1	-1.72 Beats per minute	Standard Deviation 8.045
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28	-4.39 Beats per minute	Standard Deviation 5.463
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56	-4.89 Beats per minute	Standard Deviation 7.29
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84	-3.72 Beats per minute	Standard Deviation 6.191
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112	-1.89 Beats per minute	Standard Deviation 3.959
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140	-1.39 Beats per minute	Standard Deviation 6.591
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140	-5.22 Beats per minute	Standard Deviation 6.649
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168	-3.56 Beats per minute	Standard Deviation 7.745
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET	1.11 Beats per minute	Standard Deviation 7.067
RN6G 15 mg/kg	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET	0.94 Beats per minute	Standard Deviation 6.22
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84	4.00 Beats per minute	Standard Deviation 12.243
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140	0.47 Beats per minute	Standard Deviation 12.613
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56	-1.11 Beats per minute	Standard Deviation 4.617
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28	-3.78 Beats per minute	Standard Deviation 5.496
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline	65.44 Beats per minute	Standard Deviation 7.556
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168	2.20 Beats per minute	Standard Deviation 5.316
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1	4.00 Beats per minute	Standard Deviation 7.226
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1	2.72 Beats per minute	Standard Deviation 10.603
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET	3.08 Beats per minute	Standard Deviation 9.094
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET	-3.44 Beats per minute	Standard Deviation 5.73
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140	-2.13 Beats per minute	Standard Deviation 10.038
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140	0.93 Beats per minute	Standard Deviation 3.919
Placebo	Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112	3.00 Beats per minute	Standard Deviation 6.342

Secondary

Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Following parameters were analyzed for laboratory examination: Aspartate Aminotransferase (AMT), Creatine Kinase (CK), Alanine Aminotransferase (ALT), Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase (LD), Alkaline Phosphatase (AP).

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: AST	-3.3 international units per liter (IU/L)	Standard Deviation 4.27
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: CK	-0.5 international units per liter (IU/L)	Standard Deviation 79.89
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: CK	-15.3 international units per liter (IU/L)	Standard Deviation 12.6
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: ALT	-2.0 international units per liter (IU/L)	Standard Deviation 4.52
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: CK	-32.5 international units per liter (IU/L)	Standard Deviation 34.16
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: CK	-16.7 international units per liter (IU/L)	Standard Deviation 28.79
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: LD	-3.0 international units per liter (IU/L)	Standard Deviation 30.42
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: ALT	-3.0 international units per liter (IU/L)	Standard Deviation 4.15
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: CK	-29.3 international units per liter (IU/L)	Standard Deviation 24.47
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: GGT	-3.3 international units per liter (IU/L)	Standard Deviation 3.33
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: CK	15.0 international units per liter (IU/L)	Standard Deviation 43.26
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: AP	63.5 international units per liter (IU/L)	Standard Deviation 20.34
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: ALT	8.2 international units per liter (IU/L)	Standard Deviation 25.13
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: ALT	17.0 international units per liter (IU/L)	Standard Deviation 4
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: ALT	-1.8 international units per liter (IU/L)	Standard Deviation 4.07
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: ALT	-0.3 international units per liter (IU/L)	Standard Deviation 5.13
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: ALT	1.8 international units per liter (IU/L)	Standard Deviation 3.54
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: AP	-1.3 international units per liter (IU/L)	Standard Deviation 3.72
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: LD	-11.3 international units per liter (IU/L)	Standard Deviation 9.4
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: GGT	-5.0 international units per liter (IU/L)	Standard Deviation 4.52
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: AP	-2.3 international units per liter (IU/L)	Standard Deviation 6.56
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: AP	-2.3 international units per liter (IU/L)	Standard Deviation 8.62
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: AST	0.2 international units per liter (IU/L)	Standard Deviation 5.81
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: GGT	-4.5 international units per liter (IU/L)	Standard Deviation 5.01
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: AP	-1.7 international units per liter (IU/L)	Standard Deviation 7.17
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: LD	-15.7 international units per liter (IU/L)	Standard Deviation 13.06
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: AP	-1.0 international units per liter (IU/L)	Standard Deviation 12.12
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: LD	-18.0 international units per liter (IU/L)	Standard Deviation 6.9
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: GGT	-2.2 international units per liter (IU/L)	Standard Deviation 6.88
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: AP	-1.3 international units per liter (IU/L)	Standard Deviation 8.36
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: AST	22.2 international units per liter (IU/L)	Standard Deviation 3.13
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: AST	-1.2 international units per liter (IU/L)	Standard Deviation 8.16
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: GGT	-2.0 international units per liter (IU/L)	Standard Deviation 4.05
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: AST	1.3 international units per liter (IU/L)	Standard Deviation 3.93
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: LD	-17.3 international units per liter (IU/L)	Standard Deviation 9.65
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: AST	-3.5 international units per liter (IU/L)	Standard Deviation 2.95
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: AST	-3.2 international units per liter (IU/L)	Standard Deviation 2.64
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: ALT	1.0 international units per liter (IU/L)	Standard Deviation 3.69
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: GGT	-2.3 international units per liter (IU/L)	Standard Deviation 3.39
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: AST	0.3 international units per liter (IU/L)	Standard Deviation 4.18
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: LD	174.5 international units per liter (IU/L)	Standard Deviation 13.4
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: LD	-7.5 international units per liter (IU/L)	Standard Deviation 18.56
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: GGT	-2.7 international units per liter (IU/L)	Standard Deviation 2.58
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: CK	97.2 international units per liter (IU/L)	Standard Deviation 40.32
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: AP	3.3 international units per liter (IU/L)	Standard Deviation 9.95
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: GGT	22.0 international units per liter (IU/L)	Standard Deviation 6.78
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: LD	5.7 international units per liter (IU/L)	Standard Deviation 27.16
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: CK	-26.3 international units per liter (IU/L)	Standard Deviation 26.07
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: LD	-6.5 international units per liter (IU/L)	Standard Deviation 17.56
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: LD	-6.0 international units per liter (IU/L)	Standard Deviation 13.11
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: AP	-0.5 international units per liter (IU/L)	Standard Deviation 10.84
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: AP	-5.8 international units per liter (IU/L)	Standard Deviation 14.8
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: GGT	-0.8 international units per liter (IU/L)	Standard Deviation 4.75
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: AST	-0.7 international units per liter (IU/L)	Standard Deviation 4.27
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: AP	-6.5 international units per liter (IU/L)	Standard Deviation 10.8
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: AST	-0.5 international units per liter (IU/L)	Standard Deviation 2.35
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: CK	-4.2 international units per liter (IU/L)	Standard Deviation 12.48
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: AST	2.0 international units per liter (IU/L)	Standard Deviation 1.67
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: ALT	-1.2 international units per liter (IU/L)	Standard Deviation 3.54
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: GGT	-0.3 international units per liter (IU/L)	Standard Deviation 3.93
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: CK	1.0 international units per liter (IU/L)	Standard Deviation 18.22
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: GGT	-1.5 international units per liter (IU/L)	Standard Deviation 3.39
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: AST	-0.5 international units per liter (IU/L)	Standard Deviation 1.87
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: AP	-4.2 international units per liter (IU/L)	Standard Deviation 10.61
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: CK	7.5 international units per liter (IU/L)	Standard Deviation 18.73
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: LD	-5.2 international units per liter (IU/L)	Standard Deviation 15.56
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: ALT	-1.8 international units per liter (IU/L)	Standard Deviation 3.49
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: LD	0.0 international units per liter (IU/L)	Standard Deviation 17.42
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: CK	7.7 international units per liter (IU/L)	Standard Deviation 19.71
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: ALT	0.3 international units per liter (IU/L)	Standard Deviation 1.97
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: AST	21.2 international units per liter (IU/L)	Standard Deviation 1.6
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: LD	-10.0 international units per liter (IU/L)	Standard Deviation 7.69
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: CK	16.3 international units per liter (IU/L)	Standard Deviation 45.35
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: GGT	-0.7 international units per liter (IU/L)	Standard Deviation 2.34
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: ALT	2.2 international units per liter (IU/L)	Standard Deviation 2.48
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: GGT	-2.3 international units per liter (IU/L)	Standard Deviation 4.32
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: CK	19.0 international units per liter (IU/L)	Standard Deviation 29.14
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: AST	-1.0 international units per liter (IU/L)	Standard Deviation 1.41
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: LD	174.7 international units per liter (IU/L)	Standard Deviation 25.11
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: CK	61.8 international units per liter (IU/L)	Standard Deviation 134
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: AP	72.5 international units per liter (IU/L)	Standard Deviation 22.65
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: ALT	-1.2 international units per liter (IU/L)	Standard Deviation 2.4
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: CK	0.7 international units per liter (IU/L)	Standard Deviation 15.06
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: ALT	19.5 international units per liter (IU/L)	Standard Deviation 1.64
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: LD	-14.5 international units per liter (IU/L)	Standard Deviation 9.89
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: CK	104.8 international units per liter (IU/L)	Standard Deviation 74.79
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: AST	0.0 international units per liter (IU/L)	Standard Deviation 0.89
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: ALT	0.3 international units per liter (IU/L)	Standard Deviation 2.66
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: GGT	-2.3 international units per liter (IU/L)	Standard Deviation 5.01
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: ALT	0.8 international units per liter (IU/L)	Standard Deviation 1.6
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: GGT	21.5 international units per liter (IU/L)	Standard Deviation 8.29
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: GGT	-1.3 international units per liter (IU/L)	Standard Deviation 3.27
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: AP	-4.0 international units per liter (IU/L)	Standard Deviation 4.43
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: ALT	-1.0 international units per liter (IU/L)	Standard Deviation 3.46
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: AST	-0.2 international units per liter (IU/L)	Standard Deviation 2.48
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: LD	-14.0 international units per liter (IU/L)	Standard Deviation 21.95
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: AP	-4.7 international units per liter (IU/L)	Standard Deviation 3.98
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: LD	-3.5 international units per liter (IU/L)	Standard Deviation 17.93
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: GGT	-2.2 international units per liter (IU/L)	Standard Deviation 4.71
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: AP	-6.0 international units per liter (IU/L)	Standard Deviation 9.32
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: AP	-0.8 international units per liter (IU/L)	Standard Deviation 6.31
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: AST	-0.3 international units per liter (IU/L)	Standard Deviation 3.14
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: GGT	-1.2 international units per liter (IU/L)	Standard Deviation 2.48
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: AST	-5.8 international units per liter (IU/L)	Standard Deviation 11.61
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: AST	-5.2 international units per liter (IU/L)	Standard Deviation 9.58
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: LD	-1.7 international units per liter (IU/L)	Standard Deviation 13.69
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: LD	-0.8 international units per liter (IU/L)	Standard Deviation 12.72
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: LD	-1.0 international units per liter (IU/L)	Standard Deviation 15.48
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: LD	-2.8 international units per liter (IU/L)	Standard Deviation 13.51
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: LD	4.8 international units per liter (IU/L)	Standard Deviation 18.63
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: LD	7.2 international units per liter (IU/L)	Standard Deviation 19.22
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: AP	59.3 international units per liter (IU/L)	Standard Deviation 12.72
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: AP	-6.8 international units per liter (IU/L)	Standard Deviation 2.5
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: AP	-5.3 international units per liter (IU/L)	Standard Deviation 9.87
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: AP	-7.7 international units per liter (IU/L)	Standard Deviation 9.67
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: AP	-6.5 international units per liter (IU/L)	Standard Deviation 8.24
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: AP	-6.5 international units per liter (IU/L)	Standard Deviation 8.98
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: AP	-5.8 international units per liter (IU/L)	Standard Deviation 11.25
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: AST	25.5 international units per liter (IU/L)	Standard Deviation 11.38
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: AST	-6.8 international units per liter (IU/L)	Standard Deviation 12.26
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: AST	-3.7 international units per liter (IU/L)	Standard Deviation 10.05
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: AST	-4.3 international units per liter (IU/L)	Standard Deviation 11.02
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: AST	-6.2 international units per liter (IU/L)	Standard Deviation 9.26
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: AST	-3.8 international units per liter (IU/L)	Standard Deviation 11.34
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: AST	-3.8 international units per liter (IU/L)	Standard Deviation 9.77
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: AP	-6.2 international units per liter (IU/L)	Standard Deviation 10.94
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: AP	-3.3 international units per liter (IU/L)	Standard Deviation 11.52
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: LD	-1.2 international units per liter (IU/L)	Standard Deviation 13.51
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: CK	80.0 international units per liter (IU/L)	Standard Deviation 20.21
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: CK	-7.3 international units per liter (IU/L)	Standard Deviation 24.1
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: CK	12.0 international units per liter (IU/L)	Standard Deviation 11.45
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: CK	7.5 international units per liter (IU/L)	Standard Deviation 26.77
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: CK	2.8 international units per liter (IU/L)	Standard Deviation 13.1
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: CK	0.5 international units per liter (IU/L)	Standard Deviation 29.92
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: CK	21.7 international units per liter (IU/L)	Standard Deviation 59.27
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: CK	77.8 international units per liter (IU/L)	Standard Deviation 148.91
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: CK	19.0 international units per liter (IU/L)	Standard Deviation 31.69
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: ALT	24.3 international units per liter (IU/L)	Standard Deviation 14.14
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: ALT	-11.3 international units per liter (IU/L)	Standard Deviation 14.24
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: ALT	-6.2 international units per liter (IU/L)	Standard Deviation 13.7
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: ALT	-6.8 international units per liter (IU/L)	Standard Deviation 14.13
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: ALT	-7.2 international units per liter (IU/L)	Standard Deviation 14.5
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: ALT	-6.5 international units per liter (IU/L)	Standard Deviation 10.54
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: ALT	-8.7 international units per liter (IU/L)	Standard Deviation 13.81
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: ALT	-6.7 international units per liter (IU/L)	Standard Deviation 13.28
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: ALT	-6.8 international units per liter (IU/L)	Standard Deviation 12.8
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: GGT	17.3 international units per liter (IU/L)	Standard Deviation 7.37
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: GGT	-1.8 international units per liter (IU/L)	Standard Deviation 2.06
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: GGT	0.5 international units per liter (IU/L)	Standard Deviation 2.59
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: GGT	-0.7 international units per liter (IU/L)	Standard Deviation 4.8
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: GGT	-0.2 international units per liter (IU/L)	Standard Deviation 2.04
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: GGT	-1.3 international units per liter (IU/L)	Standard Deviation 2.73
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: GGT	0.2 international units per liter (IU/L)	Standard Deviation 2.56
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: GGT	0.5 international units per liter (IU/L)	Standard Deviation 1.97
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: LD	166.7 international units per liter (IU/L)	Standard Deviation 19.65
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: LD	-8.0 international units per liter (IU/L)	Standard Deviation 15.47
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: LD	0.2 international units per liter (IU/L)	Standard Deviation 18.35
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: ALT	0.8 international units per liter (IU/L)	Standard Deviation 4.55
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: CK	9.2 international units per liter (IU/L)	Standard Deviation 18.69
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: CK	67.5 international units per liter (IU/L)	Standard Deviation 26.91
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: LD	-4.3 international units per liter (IU/L)	Standard Deviation 20.26
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: ALT	0.3 international units per liter (IU/L)	Standard Deviation 3.44
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: AP	9.3 international units per liter (IU/L)	Standard Deviation 18.71
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: GGT	31.5 international units per liter (IU/L)	Standard Deviation 61.07
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: ALT	13.8 international units per liter (IU/L)	Standard Deviation 25.33
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: AP	8.8 international units per liter (IU/L)	Standard Deviation 9.45
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: AP	3.4 international units per liter (IU/L)	Standard Deviation 5.55
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: LD	-1.2 international units per liter (IU/L)	Standard Deviation 16.57
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: GGT	20.0 international units per liter (IU/L)	Standard Deviation 10.32
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: AST	7.5 international units per liter (IU/L)	Standard Deviation 10.47
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: AST	1.8 international units per liter (IU/L)	Standard Deviation 2.64
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: LD	-6.0 international units per liter (IU/L)	Standard Deviation 15.87
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: GGT	-0.7 international units per liter (IU/L)	Standard Deviation 1.21
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: AST	0.6 international units per liter (IU/L)	Standard Deviation 3.65
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: AST	2.5 international units per liter (IU/L)	Standard Deviation 7.79
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: AST	-1.0 international units per liter (IU/L)	Standard Deviation 4.64
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: GGT	-0.8 international units per liter (IU/L)	Standard Deviation 1.17
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: AST	-1.3 international units per liter (IU/L)	Standard Deviation 3.2
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: AST	19.5 international units per liter (IU/L)	Standard Deviation 4.55
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: LD	172.0 international units per liter (IU/L)	Standard Deviation 20.03
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: GGT	-2.0 international units per liter (IU/L)	Standard Deviation 4.12
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: AP	1.4 international units per liter (IU/L)	Standard Deviation 4.51
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: AP	5.8 international units per liter (IU/L)	Standard Deviation 5.12
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: AST	-0.8 international units per liter (IU/L)	Standard Deviation 3.86
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: GGT	-1.0 international units per liter (IU/L)	Standard Deviation 3.39
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: AP	0.2 international units per liter (IU/L)	Standard Deviation 5.89
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: AP	-0.8 international units per liter (IU/L)	Standard Deviation 3.31
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: LD	3.3 international units per liter (IU/L)	Standard Deviation 25.53
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: GGT	0.0 international units per liter (IU/L)	Standard Deviation 1.41
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: AP	-1.7 international units per liter (IU/L)	Standard Deviation 3.78
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: AP	69.7 international units per liter (IU/L)	Standard Deviation 9.73
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: LD	1.2 international units per liter (IU/L)	Standard Deviation 8.53
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: GGT	0.8 international units per liter (IU/L)	Standard Deviation 1.92
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: ALT	-0.2 international units per liter (IU/L)	Standard Deviation 0.98
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: LD	-6.5 international units per liter (IU/L)	Standard Deviation 38.66
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: ALT	3.3 international units per liter (IU/L)	Standard Deviation 11.24
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: ALT	17.2 international units per liter (IU/L)	Standard Deviation 5.27
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: CK	9.5 international units per liter (IU/L)	Standard Deviation 8.58
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: LD	-4.0 international units per liter (IU/L)	Standard Deviation 18.61
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: ALT	-2.5 international units per liter (IU/L)	Standard Deviation 3.32
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: CK	7.5 international units per liter (IU/L)	Standard Deviation 9.79
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: CK	8.8 international units per liter (IU/L)	Standard Deviation 16.16
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: AST	-2.2 international units per liter (IU/L)	Standard Deviation 2.77
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: ALT	-2.2 international units per liter (IU/L)	Standard Deviation 3.96
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: CK	53.0 international units per liter (IU/L)	Standard Deviation 106.5
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: CK	-2.0 international units per liter (IU/L)	Standard Deviation 19.79
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: GGT	1.3 international units per liter (IU/L)	Standard Deviation 3.98
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: ALT	-1.0 international units per liter (IU/L)	Standard Deviation 4.06
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: CK	3.2 international units per liter (IU/L)	Standard Deviation 14.2
Placebo	Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: CK	8.7 international units per liter (IU/L)	Standard Deviation 15.6

Secondary

Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140

Time frame: Baseline, Day 28, 56, 84, 112, 140

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline: IL-6	0.00 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 56: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 84: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 112: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 28: beta IL-1	0.32 Picogram per milliliter (pg/ml)	Standard Deviation 0.776
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 140: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline: beta IL-1	0.00 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 84: IL-6	0.00 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 140: beta IL-1	0.23 Picogram per milliliter (pg/ml)	Standard Deviation 0.572
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 112: IL-6	1.84 Picogram per milliliter (pg/ml)	Standard Deviation 2.855
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 84: beta IL-1	0.40 Picogram per milliliter (pg/ml)	Standard Deviation 0.98
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 140: IL-6	0.00 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline: alpha TNF	2.943 Picogram per milliliter (pg/ml)	Standard Deviation 1.7942
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 28: alpha TNF	1.175 Picogram per milliliter (pg/ml)	Standard Deviation 2.017
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 56: alpha TNF	0.590 Picogram per milliliter (pg/ml)	Standard Deviation 2.2536
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 56: beta IL-1	0.00 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 84: alpha TNF	1.423 Picogram per milliliter (pg/ml)	Standard Deviation 1.2367
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 28: IL-6	0.90 Picogram per milliliter (pg/ml)	Standard Deviation 1.445
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 112: alpha TNF	1.762 Picogram per milliliter (pg/ml)	Standard Deviation 1.5999
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 140: alpha TNF	1.512 Picogram per milliliter (pg/ml)	Standard Deviation 1.4736
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 112: beta IL-1	0.00 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 28: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 56: IL-6	0.67 Picogram per milliliter (pg/ml)	Standard Deviation 1.633
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline: IL-6	1.22 Picogram per milliliter (pg/ml)	Standard Deviation 1.354
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 140: IL-6	0.90 Picogram per milliliter (pg/ml)	Standard Deviation 3.366
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 112: IL-6	-0.05 Picogram per milliliter (pg/ml)	Standard Deviation 2.002
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 56: IL-6	-1.22 Picogram per milliliter (pg/ml)	Standard Deviation 1.354
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 84: IL-6	1.50 Picogram per milliliter (pg/ml)	Standard Deviation 2.386
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 28: IL-6	-1.22 Picogram per milliliter (pg/ml)	Standard Deviation 1.354
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 56: IL-6	0.10 Picogram per milliliter (pg/ml)	Standard Deviation 3.186
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 28: IL-6	1.23 Picogram per milliliter (pg/ml)	Standard Deviation 4.19
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline: IL-6	0.62 Picogram per milliliter (pg/ml)	Standard Deviation 1.511
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 140: IL-6	3.38 Picogram per milliliter (pg/ml)	Standard Deviation 5.754
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 84: IL-6	-0.05 Picogram per milliliter (pg/ml)	Standard Deviation 2.247
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 112: IL-6	-0.62 Picogram per milliliter (pg/ml)	Standard Deviation 1.511
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 140: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline: beta IL-1	0.00 Picogram per milliliter (pg/ml)	Standard Deviation 0
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 28: beta IL-1	0.00 Picogram per milliliter (pg/ml)	Standard Deviation 0
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 56: beta IL-1	0.00 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 84: beta IL-1	0.00 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 112: beta IL-1	0.00 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 140: beta IL-1	0.00 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline: IL-6	0.52 Picogram per milliliter (pg/ml)	Standard Deviation 1.163
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 28: IL-6	0.34 Picogram per milliliter (pg/ml)	Standard Deviation 0.76
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 56: IL-6	0.20 Picogram per milliliter (pg/ml)	Standard Deviation 0.4
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 84: IL-6	0.50 Picogram per milliliter (pg/ml)	Standard Deviation 1
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 112: IL-6	0.55 Picogram per milliliter (pg/ml)	Standard Deviation 1.168
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 140: IL-6	1.63 Picogram per milliliter (pg/ml)	Standard Deviation 1.95
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline: alpha TNF	3.185 Picogram per milliliter (pg/ml)	Standard Deviation 1.2657
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 28: alpha TNF	-1.425 Picogram per milliliter (pg/ml)	Standard Deviation 1.2233
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 56: alpha TNF	0.790 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 84: alpha TNF	0.520 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 112: alpha TNF	1.140 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 140: alpha TNF	1.220 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Baseline: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	Standard Deviation 0
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 28: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	Standard Deviation 0
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 56: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 84: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	—
Placebo	Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140	Change at Day 112: INF (Gamma)	0.0 Picogram per milliliter (pg/ml)	—

Secondary

Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140

Time frame: Baseline, Day 28, 56, 84, 112, 140

Population: All randomized participants who met the inclusion criteria and received any amount of study drug were included. Here, Overall Number of Participants Analyzed signifies participants evaluable for this outcome measure and Number Analyzed signifies number of participants evaluated for given time point.

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Baseline: C4D	2.692 Microgram per milliliter (mcg/mL)	Standard Deviation 1.5264
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Change at Day 28: C4D	1.078 Microgram per milliliter (mcg/mL)	Standard Deviation 4.3643
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Change at Day 56: C4D	-1.503 Microgram per milliliter (mcg/mL)	Standard Deviation 1.4911
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Change at Day 84: C4D	-0.907 Microgram per milliliter (mcg/mL)	Standard Deviation 1.6772
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Change at Day 112: C4D	-0.466 Microgram per milliliter (mcg/mL)	Standard Deviation 1.6322
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Change at Day 140: C4D	-0.338 Microgram per milliliter (mcg/mL)	Standard Deviation 1.679
Placebo	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Change at Day 112: C4D	1.060 Microgram per milliliter (mcg/mL)	—
Placebo	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Baseline: C4D	3.720 Microgram per milliliter (mcg/mL)	Standard Deviation 2.291
Placebo	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Change at Day 84: C4D	1.180 Microgram per milliliter (mcg/mL)	—
Placebo	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Change at Day 28: C4D	-1.720 Microgram per milliliter (mcg/mL)	Standard Deviation 1.0748
Placebo	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Change at Day 140: C4D	0.140 Microgram per milliliter (mcg/mL)	—
Placebo	Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140	Change at Day 56: C4D	-1.320 Microgram per milliliter (mcg/mL)	—

Secondary

Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140

Time frame: Baseline, Day 28, 56, 84, 112, 140

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 84: C5B-9	-9.8 Nanogram per milliliter (ng/mL)	Standard Deviation 152.15
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 140: C5B-9	-36.8 Nanogram per milliliter (ng/mL)	Standard Deviation 69.42
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 28: C5B-9	-33.5 Nanogram per milliliter (ng/mL)	Standard Deviation 83.69
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Baseline: C3A	970.3 Nanogram per milliliter (ng/mL)	Standard Deviation 214.77
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 56: C5B-9	-78.0 Nanogram per milliliter (ng/mL)	Standard Deviation 47.76
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 56: C3A )	404.7 Nanogram per milliliter (ng/mL)	Standard Deviation 280.7
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 84: C3A	380.3 Nanogram per milliliter (ng/mL)	Standard Deviation 341.07
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 28: C3A	560.2 Nanogram per milliliter (ng/mL)	Standard Deviation 1109.51
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 112: C5B-9	-35.8 Nanogram per milliliter (ng/mL)	Standard Deviation 63.01
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 112: C3A	445.2 Nanogram per milliliter (ng/mL)	Standard Deviation 465.87
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 140: C3A	297.8 Nanogram per milliliter (ng/mL)	Standard Deviation 508.62
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Baseline: C5B-9	289.5 Nanogram per milliliter (ng/mL)	Standard Deviation 56.64
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 28: C3A	447.5 Nanogram per milliliter (ng/mL)	Standard Deviation 457.21
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Baseline: C5B-9	199.8 Nanogram per milliliter (ng/mL)	Standard Deviation 16.87
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 84: C3A	290.2 Nanogram per milliliter (ng/mL)	Standard Deviation 414.07
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 56: C5B-9	11.3 Nanogram per milliliter (ng/mL)	Standard Deviation 59.09
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 84: C5B-9	16.6 Nanogram per milliliter (ng/mL)	Standard Deviation 105.2
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 28: C5B-9	-26.2 Nanogram per milliliter (ng/mL)	Standard Deviation 44.51
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Baseline: C3A	928.0 Nanogram per milliliter (ng/mL)	Standard Deviation 228.37
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 140: C3A	928.6 Nanogram per milliliter (ng/mL)	Standard Deviation 398.79
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 112: C3A	246.0 Nanogram per milliliter (ng/mL)	Standard Deviation 337.86
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 56: C3A )	221.0 Nanogram per milliliter (ng/mL)	Standard Deviation 202.67
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 140: C5B-9	-10.2 Nanogram per milliliter (ng/mL)	Standard Deviation 123.29
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 112: C5B-9	-15.3 Nanogram per milliliter (ng/mL)	Standard Deviation 36.68
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 28: C5B-9	-63.0 Nanogram per milliliter (ng/mL)	Standard Deviation 131.56
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Baseline: C3A	1465.8 Nanogram per milliliter (ng/mL)	Standard Deviation 352.95
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 28: C3A	161.3 Nanogram per milliliter (ng/mL)	Standard Deviation 523.83
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 56: C3A )	-74.5 Nanogram per milliliter (ng/mL)	Standard Deviation 723.41
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 84: C3A	-610.3 Nanogram per milliliter (ng/mL)	Standard Deviation 425.31
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 112: C3A	-129.5 Nanogram per milliliter (ng/mL)	Standard Deviation 454.93
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 140: C3A	-68.3 Nanogram per milliliter (ng/mL)	Standard Deviation 543.15
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Baseline: C5B-9	244.3 Nanogram per milliliter (ng/mL)	Standard Deviation 132.87
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 56: C5B-9	0.0 Nanogram per milliliter (ng/mL)	Standard Deviation 50.73
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 84: C5B-9	34.5 Nanogram per milliliter (ng/mL)	Standard Deviation 102.8
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 112: C5B-9	51.8 Nanogram per milliliter (ng/mL)	Standard Deviation 106.84
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 140: C5B-9	-13.3 Nanogram per milliliter (ng/mL)	Standard Deviation 98.95
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 140: C3A	-32.2 Nanogram per milliliter (ng/mL)	Standard Deviation 846.33
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 112: C3A	746.2 Nanogram per milliliter (ng/mL)	Standard Deviation 1686.03
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Baseline: C3A	1813.0 Nanogram per milliliter (ng/mL)	Standard Deviation 1060.66
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 84: C5B-9	4.8 Nanogram per milliliter (ng/mL)	Standard Deviation 86.14
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 84: C3A	117.0 Nanogram per milliliter (ng/mL)	Standard Deviation 826.44
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 56: C3A )	-220.6 Nanogram per milliliter (ng/mL)	Standard Deviation 231.43
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 140: C5B-9	-30.2 Nanogram per milliliter (ng/mL)	Standard Deviation 74.25
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 112: C5B-9	42.6 Nanogram per milliliter (ng/mL)	Standard Deviation 99.64
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 28: C5B-9	-85.5 Nanogram per milliliter (ng/mL)	Standard Deviation 87.54
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Baseline: C5B-9	299.7 Nanogram per milliliter (ng/mL)	Standard Deviation 154.14
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 28: C3A	-305.3 Nanogram per milliliter (ng/mL)	Standard Deviation 899.05
Placebo	Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140	Change at Day 56: C5B-9	-8.0 Nanogram per milliliter (ng/mL)	Standard Deviation 109.9

Secondary

Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Following hematology parameters were analyzed for laboratory examination: Hemoglobin, Hematocrit, Red blood cell (RBC) count, Platelet count, WBC count, Total neutrophils (Abs),Eosinophils (Abs),Monocytes (Abs),Basophils (Abs), Lymphocytes (Abs).

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Hematocrit	-0.25 Percentage of RBCs to total blood volume	Standard Deviation 1.545
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Hematocrit	-1.47 Percentage of RBCs to total blood volume	Standard Deviation 1.48
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Hematocrit	0.07 Percentage of RBCs to total blood volume	Standard Deviation 2.272
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Hematocrit	-0.53 Percentage of RBCs to total blood volume	Standard Deviation 1.458
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Hematocrit	-1.18 Percentage of RBCs to total blood volume	Standard Deviation 1.161
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Hematocrit	-0.30 Percentage of RBCs to total blood volume	Standard Deviation 1.611
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Hematocrit	-0.60 Percentage of RBCs to total blood volume	Standard Deviation 1.797
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Hematocrit	41.70 Percentage of RBCs to total blood volume	Standard Deviation 3.906
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Hematocrit	0.08 Percentage of RBCs to total blood volume	Standard Deviation 2.464
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Hematocrit	41.28 Percentage of RBCs to total blood volume	Standard Deviation 2.436
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Hematocrit	-0.67 Percentage of RBCs to total blood volume	Standard Deviation 0.864
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Hematocrit	-1.68 Percentage of RBCs to total blood volume	Standard Deviation 0.823
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Hematocrit	0.56 Percentage of RBCs to total blood volume	Standard Deviation 1.593
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Hematocrit	0.53 Percentage of RBCs to total blood volume	Standard Deviation 1.28
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Hematocrit	0.05 Percentage of RBCs to total blood volume	Standard Deviation 1.294
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Hematocrit	1.50 Percentage of RBCs to total blood volume	Standard Deviation 1.745
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Hematocrit	2.07 Percentage of RBCs to total blood volume	Standard Deviation 3.841
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Hematocrit	0.90 Percentage of RBCs to total blood volume	Standard Deviation 0.876
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Hematocrit	-0.34 Percentage of RBCs to total blood volume	Standard Deviation 3.14
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Hematocrit	-1.28 Percentage of RBCs to total blood volume	Standard Deviation 3.342
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Hematocrit	-0.78 Percentage of RBCs to total blood volume	Standard Deviation 2.92
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Hematocrit	-1.20 Percentage of RBCs to total blood volume	Standard Deviation 3.251
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Hematocrit	40.78 Percentage of RBCs to total blood volume	Standard Deviation 2.927
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Hematocrit	0.23 Percentage of RBCs to total blood volume	Standard Deviation 2.007
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Hematocrit	1.15 Percentage of RBCs to total blood volume	Standard Deviation 2.393
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Hematocrit	1.25 Percentage of RBCs to total blood volume	Standard Deviation 1.714
Placebo	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Hematocrit	-1.35 Percentage of RBCs to total blood volume	Standard Deviation 2.914
Placebo	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Hematocrit	-1.26 Percentage of RBCs to total blood volume	Standard Deviation 0.73
Placebo	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Hematocrit	-2.18 Percentage of RBCs to total blood volume	Standard Deviation 1.847
Placebo	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Hematocrit	-1.85 Percentage of RBCs to total blood volume	Standard Deviation 1.771
Placebo	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Hematocrit	0.22 Percentage of RBCs to total blood volume	Standard Deviation 2.845
Placebo	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Hematocrit	-1.73 Percentage of RBCs to total blood volume	Standard Deviation 1.866
Placebo	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Hematocrit	-1.30 Percentage of RBCs to total blood volume	Standard Deviation 1.687
Placebo	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Hematocrit	40.87 Percentage of RBCs to total blood volume	Standard Deviation 5.369
Placebo	Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Hematocrit	-1.10 Percentage of RBCs to total blood volume	Standard Deviation 5.412

Secondary

Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Monocytes (abs)	0.522 10^3 cells/microliter	Standard Deviation 0.1622
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Eosinophils (abs)	-0.008 10^3 cells/microliter	Standard Deviation 0.0685
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Eosinophils (abs)	-0.007 10^3 cells/microliter	Standard Deviation 0.0547
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: WBC	-0.08 10^3 cells/microliter	Standard Deviation 1.28
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Platelets	13.5 10^3 cells/microliter	Standard Deviation 21.19
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Eosinophils (abs)	-0.002 10^3 cells/microliter	Standard Deviation 0.0898
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Eosinophils (abs)	0.012 10^3 cells/microliter	Standard Deviation 0.0638
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: WBC	0.35 10^3 cells/microliter	Standard Deviation 1.693
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Monocytes (abs)	-0.023 10^3 cells/microliter	Standard Deviation 0.1649
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Eosinophils (abs)	0.212 10^3 cells/microliter	Standard Deviation 0.1298
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Neutrophils(abs)	0.413 10^3 cells/microliter	Standard Deviation 1.3356
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Lymphocytes(abs)	-0.025 10^3 cells/microliter	Standard Deviation 0.3961
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Neutrophils (abs)	0.137 10^3 cells/microliter	Standard Deviation 0.9677
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Neutrophils (abs)	-0.348 10^3 cells/microliter	Standard Deviation 1.1549
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Neutrophils (abs)	3.508 10^3 cells/microliter	Standard Deviation 1.4359
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Lymphocytes (abs)	-0.173 10^3 cells/microliter	Standard Deviation 0.2486
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Neutrophils (abs)	0.043 10^3 cells/microliter	Standard Deviation 0.8887
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Neutrophils (abs)	0.405 10^3 cells/microliter	Standard Deviation 1.3205
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Neutrophils (abs)	0.154 10^3 cells/microliter	Standard Deviation 0.8442
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Platelets	5.2 10^3 cells/microliter	Standard Deviation 20.97
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Neutrophils (abs)	0.237 10^3 cells/microliter	Standard Deviation 1.1972
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Monocytes (abs)	-0.020 10^3 cells/microliter	Standard Deviation 0.1753
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Lymphocytes (abs)	0.012 10^3 cells/microliter	Standard Deviation 0.2175
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Lymphocytes (abs)	0.023 10^3 cells/microliter	Standard Deviation 0.2299
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Platelets	4.5 10^3 cells/microliter	Standard Deviation 26.16
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Monocytes (abs)	0.000 10^3 cells/microliter	Standard Deviation 0.0701
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Lymphocytes (abs)	-0.063 10^3 cells/microliter	Standard Deviation 0.1973
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Platelets	187.5 10^3 cells/microliter	Standard Deviation 50.91
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Platelets	5.4 10^3 cells/microliter	Standard Deviation 9.56
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Platelets	-1.0 10^3 cells/microliter	Standard Deviation 15.38
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Lymphocytes (abs)	-0.042 10^3 cells/microliter	Standard Deviation 0.1594
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Lymphocytes (abs)	-0.160 10^3 cells/microliter	Standard Deviation 0.2853
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Monocytes (abs)	-0.005 10^3 cells/microliter	Standard Deviation 0.1566
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Lymphocytes (abs)	1.470 10^3 cells/microliter	Standard Deviation 0.3329
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Basophils (abs)	-0.008 10^3 cells/microliter	Standard Deviation 0.0147
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: WBC	5.75 10^3 cells/microliter	Standard Deviation 1.744
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Monocytes (abs)	-0.040 10^3 cells/microliter	Standard Deviation 0.1185
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Basophils (abs)	0.005 10^3 cells/microliter	Standard Deviation 0.0266
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Basophils (abs)	0.003 10^3 cells/microliter	Standard Deviation 0.0137
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: WBC	-0.02 10^3 cells/microliter	Standard Deviation 1.163
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Monocytes (abs)	-0.043 10^3 cells/microliter	Standard Deviation 0.1229
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Basophils (abs)	0.003 10^3 cells/microliter	Standard Deviation 0.0103
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Basophils (abs)	0.007 10^3 cells/microliter	Standard Deviation 0.0175
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: WBC	0.15 10^3 cells/microliter	Standard Deviation 1.104
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Platelets	-0.6 10^3 cells/microliter	Standard Deviation 14.17
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Basophils (abs)	0.003 10^3 cells/microliter	Standard Deviation 0.0137
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Basophils (abs)	0.014 10^3 cells/microliter	Standard Deviation 0.0358
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: WBC	0.30 10^3 cells/microliter	Standard Deviation 1.41
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Platelets	1.2 10^3 cells/microliter	Standard Deviation 13.55
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Basophils (abs)	0.032 10^3 cells/microliter	Standard Deviation 0.0133
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Eosinophils(abs)	-0.015 10^3 cells/microliter	Standard Deviation 0.074
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: WBC	0.05 10^3 cells/microliter	Standard Deviation 1.048
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Monocytes (abs)	-0.034 10^3 cells/microliter	Standard Deviation 0.1826
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Eosinophils (abs)	-0.042 10^3 cells/microliter	Standard Deviation 0.0786
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Eosinophils (abs)	0.028 10^3 cells/microliter	Standard Deviation 0.0567
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: WBC	-0.33 10^3 cells/microliter	Standard Deviation 1.414
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Lymphocytes (abs)	-0.190 10^3 cells/microliter	Standard Deviation 0.2155
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Platelets	209.3 10^3 cells/microliter	Standard Deviation 39.52
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Platelets	-10.7 10^3 cells/microliter	Standard Deviation 21.99
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Platelets	-14.4 10^3 cells/microliter	Standard Deviation 24.27
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Platelets	4.0 10^3 cells/microliter	Standard Deviation 22.9
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Platelets	-3.5 10^3 cells/microliter	Standard Deviation 31.05
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Platelets	-12.2 10^3 cells/microliter	Standard Deviation 16.8
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Platelets	-1.2 10^3 cells/microliter	Standard Deviation 28.49
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Platelets	-5.5 10^3 cells/microliter	Standard Deviation 27.29
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Platelets	-11.8 10^3 cells/microliter	Standard Deviation 30.33
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: WBC	6.08 10^3 cells/microliter	Standard Deviation 1.023
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: WBC	-0.40 10^3 cells/microliter	Standard Deviation 0.839
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: WBC	-0.42 10^3 cells/microliter	Standard Deviation 0.676
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: WBC	-0.28 10^3 cells/microliter	Standard Deviation 1.326
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: WBC	0.32 10^3 cells/microliter	Standard Deviation 1.341
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: WBC	0.03 10^3 cells/microliter	Standard Deviation 1.166
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: WBC	-0.13 10^3 cells/microliter	Standard Deviation 1.657
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: WBC	-0.42 10^3 cells/microliter	Standard Deviation 0.882
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: WBC	-0.18 10^3 cells/microliter	Standard Deviation 1.743
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Neutrophils (abs)	3.813 10^3 cells/microliter	Standard Deviation 1.1002
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Neutrophils (abs)	-0.320 10^3 cells/microliter	Standard Deviation 0.7102
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Neutrophils (abs)	-0.226 10^3 cells/microliter	Standard Deviation 0.7418
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Neutrophils (abs)	-0.062 10^3 cells/microliter	Standard Deviation 0.9878
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Neutrophils (abs)	0.455 10^3 cells/microliter	Standard Deviation 1.2804
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Neutrophils (abs)	0.260 10^3 cells/microliter	Standard Deviation 1.1844
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Neutrophils (abs)	0.092 10^3 cells/microliter	Standard Deviation 1.5919
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Neutrophils(abs)	-0.188 10^3 cells/microliter	Standard Deviation 0.7241
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Neutrophils(abs)	-0.035 10^3 cells/microliter	Standard Deviation 1.3786
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Eosinophils (abs)	0.242 10^3 cells/microliter	Standard Deviation 0.0823
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Eosinophils (abs)	0.020 10^3 cells/microliter	Standard Deviation 0.0994
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Eosinophils (abs)	0.012 10^3 cells/microliter	Standard Deviation 0.1215
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Eosinophils (abs)	0.074 10^3 cells/microliter	Standard Deviation 0.0832
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Eosinophils (abs)	0.053 10^3 cells/microliter	Standard Deviation 0.1285
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Eosinophils (abs)	-0.005 10^3 cells/microliter	Standard Deviation 0.0892
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Eosinophils (abs)	0.012 10^3 cells/microliter	Standard Deviation 0.0467
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Eosinophils(abs)	0.002 10^3 cells/microliter	Standard Deviation 0.083
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Eosinophils(abs)	-0.010 10^3 cells/microliter	Standard Deviation 0.1122
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Basophils (abs)	0.048 10^3 cells/microliter	Standard Deviation 0.0371
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Basophils (abs)	-0.012 10^3 cells/microliter	Standard Deviation 0.0549
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Basophils (abs)	-0.016 10^3 cells/microliter	Standard Deviation 0.0611
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Basophils (abs)	-0.014 10^3 cells/microliter	Standard Deviation 0.0404
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Basophils (abs)	-0.022 10^3 cells/microliter	Standard Deviation 0.0422
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Basophils (abs)	-0.027 10^3 cells/microliter	Standard Deviation 0.0344
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Basophils (abs)	-0.025 10^3 cells/microliter	Standard Deviation 0.0378
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Basophils (abs)	-0.027 10^3 cells/microliter	Standard Deviation 0.0294
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Basophils (abs)	-0.028 10^3 cells/microliter	Standard Deviation 0.0223
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Lymphocytes (abs)	1.528 10^3 cells/microliter	Standard Deviation 0.3669
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Lymphocytes (abs)	-0.088 10^3 cells/microliter	Standard Deviation 0.2491
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Lymphocytes (abs)	-0.256 10^3 cells/microliter	Standard Deviation 0.4282
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Lymphocytes (abs)	-0.145 10^3 cells/microliter	Standard Deviation 0.3142
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Lymphocytes (abs)	-0.188 10^3 cells/microliter	Standard Deviation 0.2584
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Lymphocytes (abs)	-0.192 10^3 cells/microliter	Standard Deviation 0.1985
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Lymphocytes(abs)	-0.200 10^3 cells/microliter	Standard Deviation 0.1579
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Lymphocytes(abs)	-0.128 10^3 cells/microliter	Standard Deviation 0.2971
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Monocytes (abs)	0.455 10^3 cells/microliter	Standard Deviation 0.144
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Monocytes (abs)	-0.033 10^3 cells/microliter	Standard Deviation 0.0898
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Monocytes (abs)	-0.020 10^3 cells/microliter	Standard Deviation 0.0265
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Monocytes (abs)	-0.022 10^3 cells/microliter	Standard Deviation 0.0991
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Monocytes (abs)	-0.017 10^3 cells/microliter	Standard Deviation 0.1061
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Monocytes (abs)	-0.013 10^3 cells/microliter	Standard Deviation 0.1058
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Monocytes (abs)	-0.017 10^3 cells/microliter	Standard Deviation 0.1216
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Monocytes (abs)	-0.025 10^3 cells/microliter	Standard Deviation 0.1154
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Monocytes (abs)	0.012 10^3 cells/microliter	Standard Deviation 0.162
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Eosinophils (abs)	-0.008 10^3 cells/microliter	Standard Deviation 0.0643
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Platelets	19.3 10^3 cells/microliter	Standard Deviation 30.32
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Basophils (abs)	0.008 10^3 cells/microliter	Standard Deviation 0.0214
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Lymphocytes (abs)	0.023 10^3 cells/microliter	Standard Deviation 0.2467
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Eosinophils(abs)	-0.057 10^3 cells/microliter	Standard Deviation 0.0831
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Platelets	5.2 10^3 cells/microliter	Standard Deviation 13.52
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Platelets	-7.0 10^3 cells/microliter	Standard Deviation 22.3
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Lymphocytes (abs)	-0.090 10^3 cells/microliter	Standard Deviation 0.1452
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: WBC	-0.87 10^3 cells/microliter	Standard Deviation 1.571
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Platelets	9.3 10^3 cells/microliter	Standard Deviation 14.49
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Basophils (abs)	-0.008 10^3 cells/microliter	Standard Deviation 0.0204
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Lymphocytes (abs)	-0.303 10^3 cells/microliter	Standard Deviation 0.2717
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: WBC	-0.35 10^3 cells/microliter	Standard Deviation 1.417
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Platelets	-2.7 10^3 cells/microliter	Standard Deviation 41.86
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Monocytes (abs)	-0.177 10^3 cells/microliter	Standard Deviation 0.2366
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Lymphocytes (abs)	-0.293 10^3 cells/microliter	Standard Deviation 0.0907
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: WBC	-0.54 10^3 cells/microliter	Standard Deviation 0.783
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Monocytes (abs)	-0.017 10^3 cells/microliter	Standard Deviation 0.1188
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Basophils (abs)	0.008 10^3 cells/microliter	Standard Deviation 0.0194
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Lymphocytes (abs)	-0.192 10^3 cells/microliter	Standard Deviation 0.2218
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Eosinophils(abs)	-0.010 10^3 cells/microliter	Standard Deviation 0.0447
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Monocytes (abs)	-0.084 10^3 cells/microliter	Standard Deviation 0.0899
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Neutrophils (abs)	-0.264 10^3 cells/microliter	Standard Deviation 0.4348
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Platelets	27.3 10^3 cells/microliter	Standard Deviation 55.97
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Neutrophils (abs)	-0.007 10^3 cells/microliter	Standard Deviation 0.4337
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Monocytes (abs)	-0.102 10^3 cells/microliter	Standard Deviation 0.07
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Basophils (abs)	-0.003 10^3 cells/microliter	Standard Deviation 0.0225
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: WBC	-0.33 10^3 cells/microliter	Standard Deviation 0.463
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Neutrophils (abs)	-0.100 10^3 cells/microliter	Standard Deviation 0.3685
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: WBC	6.17 10^3 cells/microliter	Standard Deviation 1.334
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Neutrophils (abs)	3.637 10^3 cells/microliter	Standard Deviation 0.843
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Lymphocytes(abs)	-0.048 10^3 cells/microliter	Standard Deviation 0.2303
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Neutrophils (abs)	0.218 10^3 cells/microliter	Standard Deviation 1.3491
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Platelets	198.7 10^3 cells/microliter	Standard Deviation 57.3
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Basophils (abs)	-0.007 10^3 cells/microliter	Standard Deviation 0.0225
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Basophils (abs)	0.032 10^3 cells/microliter	Standard Deviation 0.0214
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Neutrophils (abs)	-0.313 10^3 cells/microliter	Standard Deviation 1.3322
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Eosinophils (abs)	-0.082 10^3 cells/microliter	Standard Deviation 0.0891
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: WBC	0.60 10^3 cells/microliter	Standard Deviation 2.199
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Platelets	-1.0 10^3 cells/microliter	Standard Deviation 11.54
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Neutrophils (abs)	-0.398 10^3 cells/microliter	Standard Deviation 0.3572
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Basophils (abs)	0.007 10^3 cells/microliter	Standard Deviation 0.0378
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Monocytes (abs)	-0.095 10^3 cells/microliter	Standard Deviation 0.0517
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Lymphocytes(abs)	-0.180 10^3 cells/microliter	Standard Deviation 0.36
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Neutrophils(abs)	0.088 10^3 cells/microliter	Standard Deviation 0.4068
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Monocytes (abs)	-0.077 10^3 cells/microliter	Standard Deviation 0.0789
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Basophils (abs)	-0.012 10^3 cells/microliter	Standard Deviation 0.0256
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Neutrophils(abs)	0.838 10^3 cells/microliter	Standard Deviation 1.8792
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Basophils (abs)	0.002 10^3 cells/microliter	Standard Deviation 0.0349
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: WBC	-0.10 10^3 cells/microliter	Standard Deviation 0.395
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Platelets	15.5 10^3 cells/microliter	Standard Deviation 16.36
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Eosinophils (abs)	0.208 10^3 cells/microliter	Standard Deviation 0.1338
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Monocytes (abs)	-0.203 10^3 cells/microliter	Standard Deviation 0.1183
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Lymphocytes (abs)	1.748 10^3 cells/microliter	Standard Deviation 0.4477
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Monocytes (abs)	-0.128 10^3 cells/microliter	Standard Deviation 0.0781
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Eosinophils (abs)	0.012 10^3 cells/microliter	Standard Deviation 0.0676
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Eosinophils (abs)	-0.045 10^3 cells/microliter	Standard Deviation 0.0547
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: WBC	-0.82 10^3 cells/microliter	Standard Deviation 0.454
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Monocytes (abs)	0.525 10^3 cells/microliter	Standard Deviation 0.1169
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Eosinophils (abs)	0.017 10^3 cells/microliter	Standard Deviation 0.0909
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: WBC	-0.07 10^3 cells/microliter	Standard Deviation 0.579
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Eosinophils (abs)	-0.078 10^3 cells/microliter	Standard Deviation 0.0652
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Lymphocytes (abs)	-0.198 10^3 cells/microliter	Standard Deviation 0.1997
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Lymphocytes (abs)	-0.197 10^3 cells/microliter	Standard Deviation 0.376
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Eosinophils (abs)	0.043 10^3 cells/microliter	Standard Deviation 0.0842
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Eosinophils (abs)	0.058 10^3 cells/microliter	Standard Deviation 0.1003
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: WBC	-0.76 10^3 cells/microliter	Standard Deviation 1.408
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Monocytes (abs)	-0.080 10^3 cells/microliter	Standard Deviation 0.0718
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Eosinophils (abs)	0.032 10^3 cells/microliter	Standard Deviation 0.075
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Eosinophils (abs)	0.030 10^3 cells/microliter	Standard Deviation 0.0903
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: WBC	-1.08 10^3 cells/microliter	Standard Deviation 1.721
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Monocytes (abs)	-0.127 10^3 cells/microliter	Standard Deviation 0.1488
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Eosinophils(abs)	0.076 10^3 cells/microliter	Standard Deviation 0.1328
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Platelets	-3.2 10^3 cells/microliter	Standard Deviation 18.85
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Eosinophils(abs)	0.075 10^3 cells/microliter	Standard Deviation 0.1318
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Basophils (abs)	0.030 10^3 cells/microliter	Standard Deviation 0.02
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: WBC	-1.75 10^3 cells/microliter	Standard Deviation 1.26
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Basophils (abs)	-0.003 10^3 cells/microliter	Standard Deviation 0.0258
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Monocytes (abs)	-0.133 10^3 cells/microliter	Standard Deviation 0.1402
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Basophils (abs)	-0.005 10^3 cells/microliter	Standard Deviation 0.0176
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: WBC	-1.02 10^3 cells/microliter	Standard Deviation 1.88
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Basophils (abs)	0.000 10^3 cells/microliter	Standard Deviation 0.0216
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Basophils (abs)	0.002 10^3 cells/microliter	Standard Deviation 0.0217
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: WBC	7.40 10^3 cells/microliter	Standard Deviation 2.497
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Basophils (abs)	0.000 10^3 cells/microliter	Standard Deviation 0.0265
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Monocytes (abs)	-0.100 10^3 cells/microliter	Standard Deviation 0.0702
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Basophils (abs)	0.022 10^3 cells/microliter	Standard Deviation 0.0363
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Platelets	6.0 10^3 cells/microliter	Standard Deviation 37.05
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Platelets	0.7 10^3 cells/microliter	Standard Deviation 17.19
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Basophils (abs)	0.012 10^3 cells/microliter	Standard Deviation 0.0179
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Basophils (abs)	0.010 10^3 cells/microliter	Standard Deviation 0.0082
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Lymphocytes (abs)	1.598 10^3 cells/microliter	Standard Deviation 0.381
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Platelets	0.2 10^3 cells/microliter	Standard Deviation 24.77
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Monocytes (abs)	-0.090 10^3 cells/microliter	Standard Deviation 0.062
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Platelets	-2.0 10^3 cells/microliter	Standard Deviation 35.94
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Lymphocytes (abs)	-0.273 10^3 cells/microliter	Standard Deviation 0.3223
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Lymphocytes (abs)	-0.108 10^3 cells/microliter	Standard Deviation 0.0171
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Platelets	-2.0 10^3 cells/microliter	Standard Deviation 17.72
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Monocytes (abs)	-0.080 10^3 cells/microliter	Standard Deviation 0.1259
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Lymphocytes (abs)	-0.238 10^3 cells/microliter	Standard Deviation 0.3872
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Lymphocytes (abs)	-0.084 10^3 cells/microliter	Standard Deviation 0.4824
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Platelets	10.4 10^3 cells/microliter	Standard Deviation 29.95
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Monocytes (abs)	-0.068 10^3 cells/microliter	Standard Deviation 0.1283
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Lymphocytes (abs)	-0.152 10^3 cells/microliter	Standard Deviation 0.5413
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Neutrophils (abs)	-0.730 10^3 cells/microliter	Standard Deviation 1.9961
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Neutrophils (abs)	-1.342 10^3 cells/microliter	Standard Deviation 1.2706
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Neutrophils (abs)	5.077 10^3 cells/microliter	Standard Deviation 2.3807
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Platelets	204.2 10^3 cells/microliter	Standard Deviation 51.86
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Neutrophils (abs)	-0.925 10^3 cells/microliter	Standard Deviation 1.7647
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Neutrophils (abs)	-0.502 10^3 cells/microliter	Standard Deviation 1.5264
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: WBC	-0.98 10^3 cells/microliter	Standard Deviation 1.513
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Lymphocytes(abs)	0.118 10^3 cells/microliter	Standard Deviation 0.3841
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Neutrophils (abs)	-0.968 10^3 cells/microliter	Standard Deviation 1.641
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Monocytes (abs)	-0.065 10^3 cells/microliter	Standard Deviation 0.0915
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Neutrophils (abs)	-0.020 10^3 cells/microliter	Standard Deviation 1.9093
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: WBC	-0.82 10^3 cells/microliter	Standard Deviation 1.329
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Neutrophils(abs)	-0.972 10^3 cells/microliter	Standard Deviation 1.1744
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Lymphocytes(abs)	-0.180 10^3 cells/microliter	Standard Deviation 0.1911
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Neutrophils(abs)	-0.815 10^3 cells/microliter	Standard Deviation 1.3199
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Platelets	9.8 10^3 cells/microliter	Standard Deviation 31.96
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Eosinophils (abs)	0.162 10^3 cells/microliter	Standard Deviation 0.1005
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: WBC	-0.16 10^3 cells/microliter	Standard Deviation 1.766
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Eosinophils (abs)	0.027 10^3 cells/microliter	Standard Deviation 0.0871
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Eosinophils (abs)	-0.007 10^3 cells/microliter	Standard Deviation 0.0628
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: WBC	-1.06 10^3 cells/microliter	Standard Deviation 1.324
Placebo	Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Monocytes (abs)	0.542 10^3 cells/microliter	Standard Deviation 0.1569

Secondary

Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Albumin	-0.12 Gram per deciliter (g/dL)	Standard Deviation 0.313
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Protein	-0.33 Gram per deciliter (g/dL)	Standard Deviation 0.273
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Albumin	0.02 Gram per deciliter (g/dL)	Standard Deviation 0.098
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Albumin	0.08 Gram per deciliter (g/dL)	Standard Deviation 0.319
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Albumin	-0.10 Gram per deciliter (g/dL)	Standard Deviation 0.19
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Protein	-0.18 Gram per deciliter (g/dL)	Standard Deviation 0.354
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Protein	7.07 Gram per deciliter (g/dL)	Standard Deviation 0.273
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Albumin	4.23 Gram per deciliter (g/dL)	Standard Deviation 0.301
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Hemoglobin	-0.48 Gram per deciliter (g/dL)	Standard Deviation 0.293
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Hemoglobin	-0.18 Gram per deciliter (g/dL)	Standard Deviation 0.627
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Protein	-0.08 Gram per deciliter (g/dL)	Standard Deviation 0.392
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Hemoglobin	-0.28 Gram per deciliter (g/dL)	Standard Deviation 0.471
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Hemoglobin	-0.03 Gram per deciliter (g/dL)	Standard Deviation 0.622
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Protein	-0.03 Gram per deciliter (g/dL)	Standard Deviation 0.216
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Hemoglobin	-0.12 Gram per deciliter (g/dL)	Standard Deviation 0.585
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Hemoglobin	-0.36 Gram per deciliter (g/dL)	Standard Deviation 0.493
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Hemoglobin	14.07 Gram per deciliter (g/dL)	Standard Deviation 1.392
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Protein	-0.25 Gram per deciliter (g/dL)	Standard Deviation 0.339
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Hemoglobin	-0.42 Gram per deciliter (g/dL)	Standard Deviation 0.462
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Albumin	0.03 Gram per deciliter (g/dL)	Standard Deviation 0.175
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Albumin	-0.17 Gram per deciliter (g/dL)	Standard Deviation 0.175
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Protein	-0.28 Gram per deciliter (g/dL)	Standard Deviation 0.271
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Protein	-0.25 Gram per deciliter (g/dL)	Standard Deviation 0.274
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Albumin	-0.08 Gram per deciliter (g/dL)	Standard Deviation 0.133
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Protein	-0.13 Gram per deciliter (g/dL)	Standard Deviation 0.25
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Protein	6.93 Gram per deciliter (g/dL)	Standard Deviation 0.273
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Protein	-0.25 Gram per deciliter (g/dL)	Standard Deviation 0.302
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Protein	-0.25 Gram per deciliter (g/dL)	Standard Deviation 0.207
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Protein	0.02 Gram per deciliter (g/dL)	Standard Deviation 0.293
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Protein	-0.02 Gram per deciliter (g/dL)	Standard Deviation 0.343
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Protein	-0.17 Gram per deciliter (g/dL)	Standard Deviation 0.225
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Protein	-0.17 Gram per deciliter (g/dL)	Standard Deviation 0.383
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Protein	-0.03 Gram per deciliter (g/dL)	Standard Deviation 0.339
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Albumin	4.48 Gram per deciliter (g/dL)	Standard Deviation 0.194
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Albumin	-0.12 Gram per deciliter (g/dL)	Standard Deviation 0.256
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Albumin	-0.13 Gram per deciliter (g/dL)	Standard Deviation 0.151
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Albumin	-0.02 Gram per deciliter (g/dL)	Standard Deviation 0.286
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Albumin	-0.07 Gram per deciliter (g/dL)	Standard Deviation 0.197
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Albumin	-0.15 Gram per deciliter (g/dL)	Standard Deviation 0.152
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Albumin	-0.10 Gram per deciliter (g/dL)	Standard Deviation 0.155
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Albumin	-0.05 Gram per deciliter (g/dL)	Standard Deviation 0.362
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Albumin	-0.08 Gram per deciliter (g/dL)	Standard Deviation 0.264
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Hemoglobin	14.28 Gram per deciliter (g/dL)	Standard Deviation 0.662
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Hemoglobin	-0.38 Gram per deciliter (g/dL)	Standard Deviation 0.337
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Hemoglobin	-0.68 Gram per deciliter (g/dL)	Standard Deviation 0.356
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Hemoglobin	0.08 Gram per deciliter (g/dL)	Standard Deviation 0.576
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Hemoglobin	-0.12 Gram per deciliter (g/dL)	Standard Deviation 0.714
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Hemoglobin	-0.10 Gram per deciliter (g/dL)	Standard Deviation 0.352
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Hemoglobin	-0.25 Gram per deciliter (g/dL)	Standard Deviation 0.451
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Hemoglobin	0.00 Gram per deciliter (g/dL)	Standard Deviation 0.525
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Hemoglobin	0.28 Gram per deciliter (g/dL)	Standard Deviation 1.1136
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Protein	-0.05 Gram per deciliter (g/dL)	Standard Deviation 0.383
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Hemoglobin	0.15 Gram per deciliter (g/dL)	Standard Deviation 0.709
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Albumin	-0.02 Gram per deciliter (g/dL)	Standard Deviation 0.075
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Hemoglobin	0.17 Gram per deciliter (g/dL)	Standard Deviation 0.308
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Albumin	0.02 Gram per deciliter (g/dL)	Standard Deviation 0.232
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Protein	-0.03 Gram per deciliter (g/dL)	Standard Deviation 0.266
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Protein	6.97 Gram per deciliter (g/dL)	Standard Deviation 0.234
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Hemoglobin	0.18 Gram per deciliter (g/dL)	Standard Deviation 0.523
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Albumin	0.02 Gram per deciliter (g/dL)	Standard Deviation 0.117
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Albumin	0.00 Gram per deciliter (g/dL)	Standard Deviation 0.167
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Protein	0.02 Gram per deciliter (g/dL)	Standard Deviation 0.319
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Protein	-0.23 Gram per deciliter (g/dL)	Standard Deviation 0.386
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Protein	0.03 Gram per deciliter (g/dL)	Standard Deviation 0.258
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Hemoglobin	-0.25 Gram per deciliter (g/dL)	Standard Deviation 0.991
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Albumin	4.43 Gram per deciliter (g/dL)	Standard Deviation 0.121
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Albumin	-0.08 Gram per deciliter (g/dL)	Standard Deviation 0.16
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Hemoglobin	13.93 Gram per deciliter (g/dL)	Standard Deviation 1.007
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Protein	-0.05 Gram per deciliter (g/dL)	Standard Deviation 0.259
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Albumin	-0.13 Gram per deciliter (g/dL)	Standard Deviation 0.31
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Protein	0.02 Gram per deciliter (g/dL)	Standard Deviation 0.407
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Protein	-0.23 Gram per deciliter (g/dL)	Standard Deviation 0.207
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Hemoglobin	-0.33 Gram per deciliter (g/dL)	Standard Deviation 0.905
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Albumin	0.02 Gram per deciliter (g/dL)	Standard Deviation 0.147
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Hemoglobin	-0.55 Gram per deciliter (g/dL)	Standard Deviation 0.819
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Hemoglobin	0.05 Gram per deciliter (g/dL)	Standard Deviation 0.565
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Hemoglobin	-0.44 Gram per deciliter (g/dL)	Standard Deviation 1.029
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Albumin	0.02 Gram per deciliter (g/dL)	Standard Deviation 0.183
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Hemoglobin	-0.57 Gram per deciliter (g/dL)	Standard Deviation 0.468
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Protein	-0.36 Gram per deciliter (g/dL)	Standard Deviation 0.305
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Albumin	-0.08 Gram per deciliter (g/dL)	Standard Deviation 0.277
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Albumin	-0.14 Gram per deciliter (g/dL)	Standard Deviation 0.321
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Protein	-0.06 Gram per deciliter (g/dL)	Standard Deviation 0.378
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Albumin	0.00 Gram per deciliter (g/dL)	Standard Deviation 0.354
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Hemoglobin	-0.66 Gram per deciliter (g/dL)	Standard Deviation 0.581
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Albumin	0.12 Gram per deciliter (g/dL)	Standard Deviation 0.256
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Protein	6.77 Gram per deciliter (g/dL)	Standard Deviation 0.225
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Albumin	0.13 Gram per deciliter (g/dL)	Standard Deviation 0.377
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Protein	-0.06 Gram per deciliter (g/dL)	Standard Deviation 0.207
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Hemoglobin	-0.12 Gram per deciliter (g/dL)	Standard Deviation 0.769
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Hemoglobin	13.80 Gram per deciliter (g/dL)	Standard Deviation 1.669
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Albumin	-0.06 Gram per deciliter (g/dL)	Standard Deviation 0.152
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Protein	-0.10 Gram per deciliter (g/dL)	Standard Deviation 0.434
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Hemoglobin	-0.58 Gram per deciliter (g/dL)	Standard Deviation 0.507
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Hemoglobin	-0.58 Gram per deciliter (g/dL)	Standard Deviation 0.96
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Protein	0.35 Gram per deciliter (g/dL)	Standard Deviation 0.404
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Hemoglobin	-0.75 Gram per deciliter (g/dL)	Standard Deviation 0.387
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Protein	0.10 Gram per deciliter (g/dL)	Standard Deviation 0.572
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Protein	-0.15 Gram per deciliter (g/dL)	Standard Deviation 0.266
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Albumin	4.28 Gram per deciliter (g/dL)	Standard Deviation 0.172
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Protein	0.00 Gram per deciliter (g/dL)	Standard Deviation 0.529
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Hemoglobin	-0.55 Gram per deciliter (g/dL)	Standard Deviation 1.473
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Albumin	-0.03 Gram per deciliter (g/dL)	Standard Deviation 0.175
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Albumin	-0.12 Gram per deciliter (g/dL)	Standard Deviation 0.331
Placebo	Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Hemoglobin	-0.80 Gram per deciliter (g/dL)	Standard Deviation 0.592

Secondary

Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Following hematology parameters were analyzed for laboratory examination: Prothrombin Time (PT), Partial Thromboplastin Time.

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PT	0.20 Second	Standard Deviation 1.259
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PT	-0.55 Second	Standard Deviation 0.362
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PT	0.10 Second	Standard Deviation 0.758
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PT	-0.25 Second	Standard Deviation 0.327
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PT	11.82 Second	Standard Deviation 0.556
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PT	0.47 Second	Standard Deviation 0.7
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PT	-0.32 Second	Standard Deviation 1.326
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PT	-0.67 Second	Standard Deviation 0.931
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PTT	31.12 Second	Standard Deviation 3.842
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PTT	-1.77 Second	Standard Deviation 4.431
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PTT	-4.64 Second	Standard Deviation 7.314
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PTT	-3.08 Second	Standard Deviation 4.275
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PTT	-0.18 Second	Standard Deviation 6.184
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PTT	0.18 Second	Standard Deviation 5.651
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PTT	-1.83 Second	Standard Deviation 4.898
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PTT	-2.47 Second	Standard Deviation 3.686
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PT	11.53 Second	Standard Deviation 0.505
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PTT	-2.42 Second	Standard Deviation 2.87
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PTT	32.57 Second	Standard Deviation 4.457
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PT	-0.28 Second	Standard Deviation 0.92
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PTT	0.44 Second	Standard Deviation 2.235
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PTT	0.45 Second	Standard Deviation 2.338
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PTT	-0.33 Second	Standard Deviation 1.49
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PTT	-0.48 Second	Standard Deviation 3.284
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PTT	0.90 Second	Standard Deviation 4.901
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PT	-0.37 Second	Standard Deviation 0.871
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PT	-0.43 Second	Standard Deviation 0.308
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PTT	-2.02 Second	Standard Deviation 1.105
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PT	-0.02 Second	Standard Deviation 0.248
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PT	-0.42 Second	Standard Deviation 0.407
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PT	0.17 Second	Standard Deviation 0.802
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PTT	1.92 Second	Standard Deviation 3.381
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PT	-0.05 Second	Standard Deviation 0.75
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PT	-0.12 Second	Standard Deviation 0.676
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PTT	2.78 Second	Standard Deviation 8.713
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PT	0.60 Second	Standard Deviation 1.356
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PTT	4.83 Second	Standard Deviation 5.654
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PT	0.24 Second	Standard Deviation 0.82
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PT	0.15 Second	Standard Deviation 0.609
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PT	-0.28 Second	Standard Deviation 0.783
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PT	-0.73 Second	Standard Deviation 0.528
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PTT	31.63 Second	Standard Deviation 6.808
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PTT	-3.86 Second	Standard Deviation 5.106
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PTT	-1.00 Second	Standard Deviation 7.216
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PTT	1.68 Second	Standard Deviation 6.563
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PTT	1.73 Second	Standard Deviation 12.794
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PTT	1.06 Second	Standard Deviation 5.949
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PT	11.10 Second	Standard Deviation 1.056
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PT	0.18 Second	Standard Deviation 0.896
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PT	0.12 Second	Standard Deviation 0.766
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PTT	0.22 Second	Standard Deviation 6.524
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PT	0.37 Second	Standard Deviation 1.221
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PTT	-0.52 Second	Standard Deviation 2.84
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PT	-1.00 Second	Standard Deviation 1.383
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PTT	-0.02 Second	Standard Deviation 1.424
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PT	-0.42 Second	Standard Deviation 2.05
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PT	-0.27 Second	Standard Deviation 2.025
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PT	11.90 Second	Standard Deviation 1.22
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PT	-0.77 Second	Standard Deviation 1.51
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PTT	-2.02 Second	Standard Deviation 2.751
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PT	-0.95 Second	Standard Deviation 1.353
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PTT	0.17 Second	Standard Deviation 2.521
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PTT	3.95 Second	Standard Deviation 8.973
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PT	-0.58 Second	Standard Deviation 1.143
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PTT	-0.52 Second	Standard Deviation 3.801
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PT	-0.80 Second	Standard Deviation 1.037
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PTT	31.23 Second	Standard Deviation 5.46
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PT	-0.26 Second	Standard Deviation 2.019
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PTT	0.00 Second	Standard Deviation 2.302
Placebo	Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PTT	-0.28 Second	Standard Deviation 2.869

Secondary

Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: RBC	-0.07 10^6 cells/microliter	Standard Deviation 0.207
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: RBC	-0.10 10^6 cells/microliter	Standard Deviation 0.141
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: RBC	-0.02 10^6 cells/microliter	Standard Deviation 0.16
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: RBC	-0.12 10^6 cells/microliter	Standard Deviation 0.172
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: RBC	0.03 10^6 cells/microliter	Standard Deviation 0.207
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: RBC	0.02 10^6 cells/microliter	Standard Deviation 0.16
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: RBC	4.45 10^6 cells/microliter	Standard Deviation 0.394
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: RBC	-0.03 10^6 cells/microliter	Standard Deviation 0.151
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: RBC	0.10 10^6 cells/microliter	Standard Deviation 0.11
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: RBC	0.00 10^6 cells/microliter	Standard Deviation 0.255
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: RBC	-0.05 10^6 cells/microliter	Standard Deviation 0.302
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: RBC	-0.03 10^6 cells/microliter	Standard Deviation 0.207
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: RBC	-0.03 10^6 cells/microliter	Standard Deviation 0.163
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: RBC	0.15 10^6 cells/microliter	Standard Deviation 0.442
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: RBC	4.48 10^6 cells/microliter	Standard Deviation 0.407
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: RBC	-0.07 10^6 cells/microliter	Standard Deviation 0.103
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: RBC	-0.18 10^6 cells/microliter	Standard Deviation 0.11
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: RBC	-0.02 10^6 cells/microliter	Standard Deviation 0.214
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: RBC	0.03 10^6 cells/microliter	Standard Deviation 0.32
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: RBC	0.02 10^6 cells/microliter	Standard Deviation 0.098
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: RBC	-0.14 10^6 cells/microliter	Standard Deviation 0.358
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: RBC	-0.13 10^6 cells/microliter	Standard Deviation 0.242
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: RBC	0.07 10^6 cells/microliter	Standard Deviation 0.121
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: RBC	-0.22 10^6 cells/microliter	Standard Deviation 0.319
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: RBC	4.42 10^6 cells/microliter	Standard Deviation 0.417
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: RBC	-0.13 10^6 cells/microliter	Standard Deviation 0.333
Placebo	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: RBC	4.43 10^6 cells/microliter	Standard Deviation 0.677
Placebo	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: RBC	0.00 10^6 cells/microliter	Standard Deviation 0.292
Placebo	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: RBC	-0.23 10^6 cells/microliter	Standard Deviation 0.443
Placebo	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: RBC	-0.10 10^6 cells/microliter	Standard Deviation 0.335
Placebo	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: RBC	-0.22 10^6 cells/microliter	Standard Deviation 0.277
Placebo	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: RBC	-0.23 10^6 cells/microliter	Standard Deviation 0.126
Placebo	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: RBC	-0.08 10^6 cells/microliter	Standard Deviation 0.277
Placebo	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: RBC	-0.15 10^6 cells/microliter	Standard Deviation 0.176
Placebo	Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: RBC	-0.10 10^6 cells/microliter	Standard Deviation 0.187

Secondary

Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Potassium	-0.20 Milliequivalent per liter (mEq/L)	Standard Deviation 0.276
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Bicarbonate	-0.3 Milliequivalent per liter (mEq/L)	Standard Deviation 2.07
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Chloride	-1.3 Milliequivalent per liter (mEq/L)	Standard Deviation 3.72
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Chloride	-1.7 Milliequivalent per liter (mEq/L)	Standard Deviation 2.88
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Magnesium	0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.075
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Bicarbonate	0.3 Milliequivalent per liter (mEq/L)	Standard Deviation 2.94
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Chloride	-0.3 Milliequivalent per liter (mEq/L)	Standard Deviation 3.83
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Sodium	-1.3 Milliequivalent per liter (mEq/L)	Standard Deviation 4.08
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Chloride	-0.3 Milliequivalent per liter (mEq/L)	Standard Deviation 2.94
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Bicarbonate	1.0 Milliequivalent per liter (mEq/L)	Standard Deviation 2.53
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Bicarbonate	27.0 Milliequivalent per liter (mEq/L)	Standard Deviation 1.55
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Bicarbonate	0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 2.34
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Bicarbonate	0.5 Milliequivalent per liter (mEq/L)	Standard Deviation 2.17
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Sodium	0.2 Milliequivalent per liter (mEq/L)	Standard Deviation 2.4
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Bicarbonate	1.5 Milliequivalent per liter (mEq/L)	Standard Deviation 1.76
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Magnesium	-0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.098
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Magnesium	0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.075
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Sodium	-0.3 Milliequivalent per liter (mEq/L)	Standard Deviation 2.8
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Potassium	4.52 Milliequivalent per liter (mEq/L)	Standard Deviation 0.204
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Magnesium	0.00 Milliequivalent per liter (mEq/L)	Standard Deviation 0.089
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Potassium	-0.18 Milliequivalent per liter (mEq/L)	Standard Deviation 0.183
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Sodium	140.0 Milliequivalent per liter (mEq/L)	Standard Deviation 1.26
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Potassium	-0.18 Milliequivalent per liter (mEq/L)	Standard Deviation 0.223
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Magnesium	-0.03 Milliequivalent per liter (mEq/L)	Standard Deviation 0.082
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Potassium	-0.28 Milliequivalent per liter (mEq/L)	Standard Deviation 0.248
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Sodium	-0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 3.01
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Potassium	-0.10 Milliequivalent per liter (mEq/L)	Standard Deviation 0.322
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Magnesium	0.03 Milliequivalent per liter (mEq/L)	Standard Deviation 0.052
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Potassium	-0.20 Milliequivalent per liter (mEq/L)	Standard Deviation 0.253
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Potassium	0.03 Milliequivalent per liter (mEq/L)	Standard Deviation 0.121
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Magnesium	-0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.098
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Magnesium	1.72 Milliequivalent per liter (mEq/L)	Standard Deviation 0.075
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Sodium	-0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 3.2
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Chloride	103.8 Milliequivalent per liter (mEq/L)	Standard Deviation 2.48
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Sodium	-2.3 Milliequivalent per liter (mEq/L)	Standard Deviation 3.27
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Bicarbonate	0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 2.16
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Chloride	-1.8 Milliequivalent per liter (mEq/L)	Standard Deviation 2.79
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Chloride	-0.8 Milliequivalent per liter (mEq/L)	Standard Deviation 2.4
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Sodium	0.0 Milliequivalent per liter (mEq/L)	Standard Deviation 1.67
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Chloride	-1.2 Milliequivalent per liter (mEq/L)	Standard Deviation 2.48
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Potassium	0.15 Milliequivalent per liter (mEq/L)	Standard Deviation 0.394
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Potassium	-0.07 Milliequivalent per liter (mEq/L)	Standard Deviation 0.266
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Magnesium	-0.05 Milliequivalent per liter (mEq/L)	Standard Deviation 0.176
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Magnesium	-0.05 Milliequivalent per liter (mEq/L)	Standard Deviation 0.138
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Bicarbonate	0.2 Milliequivalent per liter (mEq/L)	Standard Deviation 3.06
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Potassium	-0.07 Milliequivalent per liter (mEq/L)	Standard Deviation 0.266
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Magnesium	0.00 Milliequivalent per liter (mEq/L)	Standard Deviation 0.2
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Potassium	0.40 Milliequivalent per liter (mEq/L)	Standard Deviation 0.369
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Chloride	0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 2.25
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Sodium	-0.3 Milliequivalent per liter (mEq/L)	Standard Deviation 4.46
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Bicarbonate	-0.3 Milliequivalent per liter (mEq/L)	Standard Deviation 1.21
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Sodium	1.0 Milliequivalent per liter (mEq/L)	Standard Deviation 3.41
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Chloride	-0.3 Milliequivalent per liter (mEq/L)	Standard Deviation 1.37
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Potassium	0.08 Milliequivalent per liter (mEq/L)	Standard Deviation 0.248
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Bicarbonate	-1.0 Milliequivalent per liter (mEq/L)	Standard Deviation 2.19
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Magnesium	-0.03 Milliequivalent per liter (mEq/L)	Standard Deviation 0.103
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Chloride	1.7 Milliequivalent per liter (mEq/L)	Standard Deviation 3.5
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Magnesium	0.00 Milliequivalent per liter (mEq/L)	Standard Deviation 0.126
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Bicarbonate	-1.5 Milliequivalent per liter (mEq/L)	Standard Deviation 0.84
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Potassium	0.10 Milliequivalent per liter (mEq/L)	Standard Deviation 0.303
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Chloride	1.7 Milliequivalent per liter (mEq/L)	Standard Deviation 2.34
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Sodium	0.5 Milliequivalent per liter (mEq/L)	Standard Deviation 4.14
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Sodium	1.3 Milliequivalent per liter (mEq/L)	Standard Deviation 3.01
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Chloride	1.0 Milliequivalent per liter (mEq/L)	Standard Deviation 1.79
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Sodium	137.8 Milliequivalent per liter (mEq/L)	Standard Deviation 5.88
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Bicarbonate	-0.5 Milliequivalent per liter (mEq/L)	Standard Deviation 1.87
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Chloride	100.8 Milliequivalent per liter (mEq/L)	Standard Deviation 4.88
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Bicarbonate	27.3 Milliequivalent per liter (mEq/L)	Standard Deviation 1.03
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Magnesium	0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.16
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Bicarbonate	-1.5 Milliequivalent per liter (mEq/L)	Standard Deviation 2.07
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Potassium	0.08 Milliequivalent per liter (mEq/L)	Standard Deviation 0.16
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Bicarbonate	-0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 1.51
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Magnesium	-0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.147
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Bicarbonate	-0.8 Milliequivalent per liter (mEq/L)	Standard Deviation 1.47
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Magnesium	1.88 Milliequivalent per liter (mEq/L)	Standard Deviation 0.16
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Sodium	1.5 Milliequivalent per liter (mEq/L)	Standard Deviation 3.83
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Chloride	1.0 Milliequivalent per liter (mEq/L)	Standard Deviation 2.76
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Potassium	-0.05 Milliequivalent per liter (mEq/L)	Standard Deviation 0.468
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Sodium	1.5 Milliequivalent per liter (mEq/L)	Standard Deviation 3.15
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Chloride	0.8 Milliequivalent per liter (mEq/L)	Standard Deviation 2.14
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Magnesium	0.03 Milliequivalent per liter (mEq/L)	Standard Deviation 0.151
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Chloride	0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 2.66
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Potassium	4.40 Milliequivalent per liter (mEq/L)	Standard Deviation 0.2
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Sodium	0.5 Milliequivalent per liter (mEq/L)	Standard Deviation 4.97
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Sodium	0.0 Milliequivalent per liter (mEq/L)	Standard Deviation 1.41
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Bicarbonate	-1.2 Milliequivalent per liter (mEq/L)	Standard Deviation 2.04
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Sodium	140.0 Milliequivalent per liter (mEq/L)	Standard Deviation 1.79
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Sodium	0.3 Milliequivalent per liter (mEq/L)	Standard Deviation 0.96
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Sodium	0.5 Milliequivalent per liter (mEq/L)	Standard Deviation 2.17
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Sodium	0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 3.33
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Sodium	0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 3.39
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Sodium	2.0 Milliequivalent per liter (mEq/L)	Standard Deviation 2.45
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Sodium	3.5 Milliequivalent per liter (mEq/L)	Standard Deviation 1.38
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Sodium	2.5 Milliequivalent per liter (mEq/L)	Standard Deviation 2.07
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Sodium	2.2 Milliequivalent per liter (mEq/L)	Standard Deviation 2.32
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Potassium	4.22 Milliequivalent per liter (mEq/L)	Standard Deviation 0.475
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Potassium	-0.08 Milliequivalent per liter (mEq/L)	Standard Deviation 0.15
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Potassium	-0.12 Milliequivalent per liter (mEq/L)	Standard Deviation 0.504
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Potassium	0.10 Milliequivalent per liter (mEq/L)	Standard Deviation 0.438
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Potassium	0.00 Milliequivalent per liter (mEq/L)	Standard Deviation 0.49
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Potassium	-0.03 Milliequivalent per liter (mEq/L)	Standard Deviation 0.535
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Potassium	0.08 Milliequivalent per liter (mEq/L)	Standard Deviation 0.467
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Potassium	0.20 Milliequivalent per liter (mEq/L)	Standard Deviation 0.329
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Potassium	0.38 Milliequivalent per liter (mEq/L)	Standard Deviation 0.458
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Chloride	102.5 Milliequivalent per liter (mEq/L)	Standard Deviation 2.66
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Chloride	1.0 Milliequivalent per liter (mEq/L)	Standard Deviation 2.71
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Chloride	0.5 Milliequivalent per liter (mEq/L)	Standard Deviation 2.17
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Chloride	2.0 Milliequivalent per liter (mEq/L)	Standard Deviation 3.03
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Chloride	1.7 Milliequivalent per liter (mEq/L)	Standard Deviation 2.73
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Chloride	0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 1.75
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Chloride	1.3 Milliequivalent per liter (mEq/L)	Standard Deviation 1.03
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Chloride	0.3 Milliequivalent per liter (mEq/L)	Standard Deviation 1.86
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Chloride	0.5 Milliequivalent per liter (mEq/L)	Standard Deviation 3.21
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Bicarbonate	26.5 Milliequivalent per liter (mEq/L)	Standard Deviation 2.43
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Bicarbonate	-1.8 Milliequivalent per liter (mEq/L)	Standard Deviation 4.15
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Bicarbonate	-0.5 Milliequivalent per liter (mEq/L)	Standard Deviation 1.87
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Bicarbonate	-1.5 Milliequivalent per liter (mEq/L)	Standard Deviation 3.51
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Bicarbonate	-0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 1.97
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Bicarbonate	-0.7 Milliequivalent per liter (mEq/L)	Standard Deviation 2.42
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Bicarbonate	0.2 Milliequivalent per liter (mEq/L)	Standard Deviation 2.23
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Bicarbonate	-1.5 Milliequivalent per liter (mEq/L)	Standard Deviation 1.64
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Magnesium	1.67 Milliequivalent per liter (mEq/L)	Standard Deviation 0.294
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Magnesium	-0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.126
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Magnesium	-0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.133
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Magnesium	0.03 Milliequivalent per liter (mEq/L)	Standard Deviation 0.082
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Magnesium	0.05 Milliequivalent per liter (mEq/L)	Standard Deviation 0.084
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Magnesium	-0.03 Milliequivalent per liter (mEq/L)	Standard Deviation 0.082
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Magnesium	-0.05 Milliequivalent per liter (mEq/L)	Standard Deviation 0.055
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Magnesium	-0.03 Milliequivalent per liter (mEq/L)	Standard Deviation 0.103
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Magnesium	0.00 Milliequivalent per liter (mEq/L)	Standard Deviation 0.089
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Chloride	0.6 Milliequivalent per liter (mEq/L)	Standard Deviation 2.41
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Chloride	0.2 Milliequivalent per liter (mEq/L)	Standard Deviation 2.56
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Chloride	-1.2 Milliequivalent per liter (mEq/L)	Standard Deviation 2.4
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Bicarbonate	-1.4 Milliequivalent per liter (mEq/L)	Standard Deviation 2.07
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Chloride	104.8 Milliequivalent per liter (mEq/L)	Standard Deviation 2.48
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Potassium	-0.25 Milliequivalent per liter (mEq/L)	Standard Deviation 0.173
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Magnesium	-0.06 Milliequivalent per liter (mEq/L)	Standard Deviation 0.055
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Bicarbonate	-0.8 Milliequivalent per liter (mEq/L)	Standard Deviation 3.43
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Potassium	-0.13 Milliequivalent per liter (mEq/L)	Standard Deviation 0.484
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Sodium	1.2 Milliequivalent per liter (mEq/L)	Standard Deviation 2.28
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Bicarbonate	-1.0 Milliequivalent per liter (mEq/L)	Standard Deviation 2.94
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Potassium	-0.04 Milliequivalent per liter (mEq/L)	Standard Deviation 0.586
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Potassium	0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.536
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Sodium	0.0 Milliequivalent per liter (mEq/L)	Standard Deviation 2.97
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Magnesium	1.83 Milliequivalent per liter (mEq/L)	Standard Deviation 0.052
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Potassium	0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.593
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Potassium	-0.16 Milliequivalent per liter (mEq/L)	Standard Deviation 0.439
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Sodium	141.7 Milliequivalent per liter (mEq/L)	Standard Deviation 2.07
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Magnesium	-0.10 Milliequivalent per liter (mEq/L)	Standard Deviation 0
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Potassium	-0.13 Milliequivalent per liter (mEq/L)	Standard Deviation 0.367
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Potassium	-0.23 Milliequivalent per liter (mEq/L)	Standard Deviation 0.427
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Magnesium	-0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.13
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Magnesium	0.00 Milliequivalent per liter (mEq/L)	Standard Deviation 0.063
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Potassium	4.42 Milliequivalent per liter (mEq/L)	Standard Deviation 0.354
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Sodium	1.0 Milliequivalent per liter (mEq/L)	Standard Deviation 2.45
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Sodium	-1.8 Milliequivalent per liter (mEq/L)	Standard Deviation 3.43
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Magnesium	0.00 Milliequivalent per liter (mEq/L)	Standard Deviation 0.122
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Sodium	-0.2 Milliequivalent per liter (mEq/L)	Standard Deviation 2.48
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Sodium	0.6 Milliequivalent per liter (mEq/L)	Standard Deviation 3.05
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Magnesium	-0.10 Milliequivalent per liter (mEq/L)	Standard Deviation 0.183
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Bicarbonate	-1.5 Milliequivalent per liter (mEq/L)	Standard Deviation 2.26
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Magnesium	-0.02 Milliequivalent per liter (mEq/L)	Standard Deviation 0.084
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Bicarbonate	-2.8 Milliequivalent per liter (mEq/L)	Standard Deviation 4.12
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Bicarbonate	28.0 Milliequivalent per liter (mEq/L)	Standard Deviation 1.67
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Chloride	-0.8 Milliequivalent per liter (mEq/L)	Standard Deviation 2.99
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Sodium	1.0 Milliequivalent per liter (mEq/L)	Standard Deviation 2.55
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Bicarbonate	-2.0 Milliequivalent per liter (mEq/L)	Standard Deviation 2.92
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Chloride	-1.8 Milliequivalent per liter (mEq/L)	Standard Deviation 3.54
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Chloride	-0.6 Milliequivalent per liter (mEq/L)	Standard Deviation 1.82
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Sodium	1.6 Milliequivalent per liter (mEq/L)	Standard Deviation 3.13
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Bicarbonate	-1.6 Milliequivalent per liter (mEq/L)	Standard Deviation 3.51
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Chloride	-0.2 Milliequivalent per liter (mEq/L)	Standard Deviation 3.11
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Chloride	0.8 Milliequivalent per liter (mEq/L)	Standard Deviation 2.39
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Magnesium	-0.07 Milliequivalent per liter (mEq/L)	Standard Deviation 0.121
Placebo	Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Bicarbonate	-1.2 Milliequivalent per liter (mEq/L)	Standard Deviation 2.17

Secondary

Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Urine pH is a method for evaluating urine acidity measured on a 10-point scale ranging from 0 (most acidic) to 9 (most alkaline). A lower pH means more acidity.

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Urine pH	0.00 units on a scale	Standard Deviation 0.447
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Urine pH	-0.08 units on a scale	Standard Deviation 0.492
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Urine pH	0.08 units on a scale	Standard Deviation 0.585
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Urine pH	-0.08 units on a scale	Standard Deviation 0.376
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Urine pH	-0.17 units on a scale	Standard Deviation 0.258
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Urine pH	-0.17 units on a scale	Standard Deviation 0.408
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Urine pH	-0.25 units on a scale	Standard Deviation 0.274
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Urine pH	6.33 units on a scale	Standard Deviation 0.408
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Urine pH	0.00 units on a scale	Standard Deviation 0.316
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Urine pH	5.92 units on a scale	Standard Deviation 0.376
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Urine pH	0.42 units on a scale	Standard Deviation 0.376
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Urine pH	0.17 units on a scale	Standard Deviation 0.408
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Urine pH	0.00 units on a scale	Standard Deviation 0.447
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Urine pH	0.50 units on a scale	Standard Deviation 0.548
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Urine pH	0.30 units on a scale	Standard Deviation 0.671
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Urine pH	0.25 units on a scale	Standard Deviation 0.689
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Urine pH	0.33 units on a scale	Standard Deviation 0.408
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Urine pH	0.08 units on a scale	Standard Deviation 0.204
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Urine pH	0.17 units on a scale	Standard Deviation 0.408
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Urine pH	0.30 units on a scale	Standard Deviation 0.447
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Urine pH	0.25 units on a scale	Standard Deviation 0.524
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Urine pH	0.17 units on a scale	Standard Deviation 0.516
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Urine pH	6.00 units on a scale	Standard Deviation 0
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Urine pH	0.25 units on a scale	Standard Deviation 0.418
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Urine pH	0.75 units on a scale	Standard Deviation 0.935
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Urine pH	0.25 units on a scale	Standard Deviation 0.524
Placebo	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: Urine pH	0.08 units on a scale	Standard Deviation 0.585
Placebo	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: Urine pH	0.00 units on a scale	Standard Deviation 0.354
Placebo	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: Urine pH	-0.20 units on a scale	Standard Deviation 0.57
Placebo	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: Urine pH	0.20 units on a scale	Standard Deviation 0.274
Placebo	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: Urine pH	-0.17 units on a scale	Standard Deviation 0.258
Placebo	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: Urine pH	-0.08 units on a scale	Standard Deviation 0.492
Placebo	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: Urine pH	0.00 units on a scale	Standard Deviation 0.5
Placebo	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: Urine pH	6.00 units on a scale	Standard Deviation 0.316
Placebo	Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: Urine pH	-0.13 units on a scale	Standard Deviation 0.479

Secondary

Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Urine specific gravity is a measure of the ratio of the density of urine to the density of water.

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: USG	-0.0010 ratio	Standard Deviation 0.0094
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: USG	-0.0018 ratio	Standard Deviation 0.00741
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: USG	-0.0013 ratio	Standard Deviation 0.00266
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: USG	-0.0010 ratio	Standard Deviation 0.00654
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: USG	0.0008 ratio	Standard Deviation 0.00884
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: USG	-0.0018 ratio	Standard Deviation 0.0095
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: USG	1.0197 ratio	Standard Deviation 0.00565
RN6G 5 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: USG	-0.0002 ratio	Standard Deviation 0.00462
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: USG	-0.0020 ratio	Standard Deviation 0.00447
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: USG	1.0150 ratio	Standard Deviation 0.00529
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: USG	0.0012 ratio	Standard Deviation 0.00462
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: USG	-0.0003 ratio	Standard Deviation 0.00787
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: USG	-0.0008 ratio	Standard Deviation 0.00376
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: USG	-0.0005 ratio	Standard Deviation 0.00625
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: USG	-0.0012 ratio	Standard Deviation 0.00559
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: USG	-0.0003 ratio	Standard Deviation 0.00497
RN6G 10 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: USG	-0.0028 ratio	Standard Deviation 0.00768
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: USG	0.0045 ratio	Standard Deviation 0.00568
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: USG	0.0047 ratio	Standard Deviation 0.0068
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: USG	1.0138 ratio	Standard Deviation 0.00343
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: USG	0.0058 ratio	Standard Deviation 0.00591
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: USG	0.0020 ratio	Standard Deviation 0.00636
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: USG	0.0022 ratio	Standard Deviation 0.00293
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: USG	0.0038 ratio	Standard Deviation 0.00366
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: USG	-0.0002 ratio	Standard Deviation 0.00293
RN6G 15 mg/kg	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: USG	0.0015 ratio	Standard Deviation 0.0065
Placebo	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: USG	-0.0020 ratio	Standard Deviation 0.00474
Placebo	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: USG	-0.0022 ratio	Standard Deviation 0.00527
Placebo	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: USG	0.0002 ratio	Standard Deviation 0.00277
Placebo	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: USG	-0.0022 ratio	Standard Deviation 0.00492
Placebo	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: USG	1.0242 ratio	Standard Deviation 0.00615
Placebo	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: USG	-0.0010 ratio	Standard Deviation 0.00566
Placebo	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: USG	-0.0024 ratio	Standard Deviation 0.00493
Placebo	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: USG	-0.0025 ratio	Standard Deviation 0.00259
Placebo	Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: USG	-0.0043 ratio	Standard Deviation 0.00383

Secondary

Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Time frame: Baseline, Day 1 (1 hour , 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	7687.9 Picogram per milliliter (pg/ml)	Standard Deviation 915.03
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	6047.9 Picogram per milliliter (pg/ml)	Standard Deviation 751.77
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	15889.6 Picogram per milliliter (pg/ml)	Standard Deviation 1923.62
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	10751.3 Picogram per milliliter (pg/ml)	Standard Deviation 796.75
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	6352.9 Picogram per milliliter (pg/ml)	Standard Deviation 513.41
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	4626.3 Picogram per milliliter (pg/ml)	Standard Deviation 506.1
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H post-dose Day 1	1939.6 Picogram per milliliter (pg/ml)	Standard Deviation 185.16
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	10302.9 Picogram per milliliter (pg/ml)	Standard Deviation 2886.26
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	2809.6 Picogram per milliliter (pg/ml)	Standard Deviation 534.82
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	11557.9 Picogram per milliliter (pg/ml)	Standard Deviation 2152.82
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	13922.9 Picogram per milliliter (pg/ml)	Standard Deviation 2470.45
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	12626.3 Picogram per milliliter (pg/ml)	Standard Deviation 2294.39
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H post-dose Day 1	3159.6 Picogram per milliliter (pg/ml)	Standard Deviation 510.52
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	1271.3 Picogram per milliliter (pg/ml)	Standard Deviation 131.35
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	10402.9 Picogram per milliliter (pg/ml)	Standard Deviation 1699.34
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	160.4 Picogram per milliliter (pg/ml)	Standard Deviation 36.33
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	10071.3 Picogram per milliliter (pg/ml)	Standard Deviation 1097.81
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	3534.6 Picogram per milliliter (pg/ml)	Standard Deviation 1383.04
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	15272.9 Picogram per milliliter (pg/ml)	Standard Deviation 2939.43
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	8517.9 Picogram per milliliter (pg/ml)	Standard Deviation 1608.78
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	12089.6 Picogram per milliliter (pg/ml)	Standard Deviation 2224.22
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	20889.6 Picogram per milliliter (pg/ml)	Standard Deviation 2456.19
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	12239.6 Picogram per milliliter (pg/ml)	Standard Deviation 1315.07
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	26550.3 Picogram per milliliter (pg/ml)	Standard Deviation 5860.63
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	199.7 Picogram per milliliter (pg/ml)	Standard Deviation 24.19
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	1306.4 Picogram per milliliter (pg/ml)	Standard Deviation 184.77
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H post-dose Day 1	2082.4 Picogram per milliliter (pg/ml)	Standard Deviation 457.09
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H post-dose Day 1	3290.3 Picogram per milliliter (pg/ml)	Standard Deviation 525.32
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	10256.8 Picogram per milliliter (pg/ml)	Standard Deviation 1125.2
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	18817.0 Picogram per milliliter (pg/ml)	Standard Deviation 4600.38
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	16450.3 Picogram per milliliter (pg/ml)	Standard Deviation 4571.75
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	12467.0 Picogram per milliliter (pg/ml)	Standard Deviation 3360.84
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	9117.0 Picogram per milliliter (pg/ml)	Standard Deviation 2492.73
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	18746.0 Picogram per milliliter (pg/ml)	Standard Deviation 4221.27
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	14645.3 Picogram per milliliter (pg/ml)	Standard Deviation 5174.94
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	24750.3 Picogram per milliliter (pg/ml)	Standard Deviation 5951.71
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	20800.3 Picogram per milliliter (pg/ml)	Standard Deviation 6538.53
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	25900.3 Picogram per milliliter (pg/ml)	Standard Deviation 6385.93
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	23517.0 Picogram per milliliter (pg/ml)	Standard Deviation 6359.32
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	20192.0 Picogram per milliliter (pg/ml)	Standard Deviation 10768.73
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	25550.3 Picogram per milliliter (pg/ml)	Standard Deviation 6073.42
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	26717.0 Picogram per milliliter (pg/ml)	Standard Deviation 5581.26
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	25283.7 Picogram per milliliter (pg/ml)	Standard Deviation 5234.95
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	31733.7 Picogram per milliliter (pg/ml)	Standard Deviation 6395.71
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 154	25050.3 Picogram per milliliter (pg/ml)	Standard Deviation 5480.9
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	21517.0 Picogram per milliliter (pg/ml)	Standard Deviation 5926.14
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	8518.7 Picogram per milliliter (pg/ml)	Standard Deviation 2946.68
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at day 304/ET	2483.7 Picogram per milliliter (pg/ml)	Standard Deviation 1124.28
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	209.2 Picogram per milliliter (pg/ml)	Standard Deviation 13.26
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	36114.8 Picogram per milliliter (pg/ml)	Standard Deviation 6268.68
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	37614.8 Picogram per milliliter (pg/ml)	Standard Deviation 8703.34
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	29170.8 Picogram per milliliter (pg/ml)	Standard Deviation 5936.75
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at day 304/ET	3340.8 Picogram per milliliter (pg/ml)	Standard Deviation 994.48
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	36750.8 Picogram per milliliter (pg/ml)	Standard Deviation 14910.47
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H post-dose Day 1	3202.3 Picogram per milliliter (pg/ml)	Standard Deviation 730.89
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	1548.8 Picogram per milliliter (pg/ml)	Standard Deviation 398.99
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	14190.8 Picogram per milliliter (pg/ml)	Standard Deviation 3337.13
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	36750.8 Picogram per milliliter (pg/ml)	Standard Deviation 5023.07
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	39990.8 Picogram per milliliter (pg/ml)	Standard Deviation 8261.8
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	15410.8 Picogram per milliliter (pg/ml)	Standard Deviation 3844.36
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	33910.8 Picogram per milliliter (pg/ml)	Standard Deviation 4820.26
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	17990.8 Picogram per milliliter (pg/ml)	Standard Deviation 4568.62
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	28250.8 Picogram per milliliter (pg/ml)	Standard Deviation 2534.65
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	24150.8 Picogram per milliliter (pg/ml)	Standard Deviation 1138.42
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	24150.8 Picogram per milliliter (pg/ml)	Standard Deviation 3178.81
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	11164.8 Picogram per milliliter (pg/ml)	Standard Deviation 563.89
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	34470.8 Picogram per milliliter (pg/ml)	Standard Deviation 7089.1
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	20630.8 Picogram per milliliter (pg/ml)	Standard Deviation 3400.87
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	23270.8 Picogram per milliliter (pg/ml)	Standard Deviation 1691.32
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	19050.8 Picogram per milliliter (pg/ml)	Standard Deviation 3495.78
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 154	47310.8 Picogram per milliliter (pg/ml)	Standard Deviation 2244.59
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	26910.8 Picogram per milliliter (pg/ml)	Standard Deviation 1110.6
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H post-dose Day 1	2264.8 Picogram per milliliter (pg/ml)	Standard Deviation 438.4
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	-33.0 Picogram per milliliter (pg/ml)	Standard Deviation 24.37
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 154	-35.8 Picogram per milliliter (pg/ml)	Standard Deviation 37.98
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	-15.6 Picogram per milliliter (pg/ml)	Standard Deviation 61.32
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	224.3 Picogram per milliliter (pg/ml)	Standard Deviation 61.26
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	-15.6 Picogram per milliliter (pg/ml)	Standard Deviation 36.92
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	-5.5 Picogram per milliliter (pg/ml)	Standard Deviation 21.94
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at day 304/ET	26.8 Picogram per milliliter (pg/ml)	Standard Deviation 87.01
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	-18.6 Picogram per milliliter (pg/ml)	Standard Deviation 35.53
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H post-dose Day 1	4.2 Picogram per milliliter (pg/ml)	Standard Deviation 27.8
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	7.0 Picogram per milliliter (pg/ml)	Standard Deviation 56.04
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	26.8 Picogram per milliliter (pg/ml)	Standard Deviation 102.19
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H post-dose Day 1	-0.7 Picogram per milliliter (pg/ml)	Standard Deviation 27.1
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	-20.4 Picogram per milliliter (pg/ml)	Standard Deviation 52.83
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	-9.0 Picogram per milliliter (pg/ml)	Standard Deviation 41.35
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	-31.0 Picogram per milliliter (pg/ml)	Standard Deviation 27.6
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	-3.7 Picogram per milliliter (pg/ml)	Standard Deviation 21.1
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	-27.4 Picogram per milliliter (pg/ml)	Standard Deviation 38.63
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	8.2 Picogram per milliliter (pg/ml)	Standard Deviation 27.46
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	-3.0 Picogram per milliliter (pg/ml)	Standard Deviation 17.44
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	-24.2 Picogram per milliliter (pg/ml)	Standard Deviation 40.38
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	-7.7 Picogram per milliliter (pg/ml)	Standard Deviation 46.88
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	-6.5 Picogram per milliliter (pg/ml)	Standard Deviation 13.91
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	15.3 Picogram per milliliter (pg/ml)	Standard Deviation 66.79
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	-16.8 Picogram per milliliter (pg/ml)	Standard Deviation 46.67
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	-2.8 Picogram per milliliter (pg/ml)	Standard Deviation 16.02

Secondary

Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Time frame: Baseline, Day 1 (1 hour, 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	8.6 picogram per milliliter (pg/ml)	Standard Deviation 9.82
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	39.5 picogram per milliliter (pg/ml)	Standard Deviation 4.78
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	34.0 picogram per milliliter (pg/ml)	Standard Deviation 5.61
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	65.3 picogram per milliliter (pg/ml)	Standard Deviation 15.08
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H post-dose Day 1	84.6 picogram per milliliter (pg/ml)	Standard Deviation 21.5
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H post-dose Day 1	100.0 picogram per milliliter (pg/ml)	Standard Deviation 18.5
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	88.6 picogram per milliliter (pg/ml)	Standard Deviation 32.58
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	42.1 picogram per milliliter (pg/ml)	Standard Deviation 16.79
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	18.7 picogram per milliliter (pg/ml)	Standard Deviation 9.18
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	13.9 picogram per milliliter (pg/ml)	Standard Deviation 5.23
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	4.8 picogram per milliliter (pg/ml)	Standard Deviation 3.31
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	31.3 picogram per milliliter (pg/ml)	Standard Deviation 7.24
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	18.0 picogram per milliliter (pg/ml)	Standard Deviation 7.94
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	28.9 picogram per milliliter (pg/ml)	Standard Deviation 11.25
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	25.6 picogram per milliliter (pg/ml)	Standard Deviation 3.6
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	41.9 picogram per milliliter (pg/ml)	Standard Deviation 6.37
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	26.2 picogram per milliliter (pg/ml)	Standard Deviation 8.53
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	56.3 picogram per milliliter (pg/ml)	Standard Deviation 11.71
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	37.2 picogram per milliliter (pg/ml)	Standard Deviation 8.51
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	87.8 picogram per milliliter (pg/ml)	Standard Deviation 10.7
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	113.2 picogram per milliliter (pg/ml)	Standard Deviation 19.82
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	132.3 picogram per milliliter (pg/ml)	Standard Deviation 12.73
RN6G 5 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	120.0 picogram per milliliter (pg/ml)	Standard Deviation 15.08
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	209.2 picogram per milliliter (pg/ml)	Standard Deviation 51.64
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	80.2 picogram per milliliter (pg/ml)	Standard Deviation 59.94
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	77.4 picogram per milliliter (pg/ml)	Standard Deviation 26.92
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	72.7 picogram per milliliter (pg/ml)	Standard Deviation 50.7
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	-1.8 picogram per milliliter (pg/ml)	Standard Deviation 41.26
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	8.4 picogram per milliliter (pg/ml)	Standard Deviation 28.46
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at day 304/ET	-3.6 picogram per milliliter (pg/ml)	Standard Deviation 40.36
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	67.3 picogram per milliliter (pg/ml)	Standard Deviation 36.14
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	177.5 picogram per milliliter (pg/ml)	Standard Deviation 67.55
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	72.4 picogram per milliliter (pg/ml)	Standard Deviation 14.51
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	243.7 picogram per milliliter (pg/ml)	Standard Deviation 58.08
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H post-dose Day 1	126.8 picogram per milliliter (pg/ml)	Standard Deviation 36.79
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	50.9 picogram per milliliter (pg/ml)	Standard Deviation 31.77
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H post-dose Day 1	179.5 picogram per milliliter (pg/ml)	Standard Deviation 34.06
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	194.8 picogram per milliliter (pg/ml)	Standard Deviation 48.89
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	56.6 picogram per milliliter (pg/ml)	Standard Deviation 61.02
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	42.4 picogram per milliliter (pg/ml)	Standard Deviation 43.12
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	78.0 picogram per milliliter (pg/ml)	Standard Deviation 51.53
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	56.3 picogram per milliliter (pg/ml)	Standard Deviation 54.71
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	280.2 picogram per milliliter (pg/ml)	Standard Deviation 81.8
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	94.4 picogram per milliliter (pg/ml)	Standard Deviation 49.79
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	33.2 picogram per milliliter (pg/ml)	Standard Deviation 34.62
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	88.2 picogram per milliliter (pg/ml)	Standard Deviation 58.68
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	115.0 picogram per milliliter (pg/ml)	Standard Deviation 68.5
RN6G 10 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 154	113.4 picogram per milliliter (pg/ml)	Standard Deviation 72.67
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	71.2 picogram per milliliter (pg/ml)	Standard Deviation 13.06
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	360.9 picogram per milliliter (pg/ml)	Standard Deviation 66.62
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	136.3 picogram per milliliter (pg/ml)	Standard Deviation 9.43
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	141.1 picogram per milliliter (pg/ml)	Standard Deviation 47.02
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	101.3 picogram per milliliter (pg/ml)	Standard Deviation 25.8
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	292.9 picogram per milliliter (pg/ml)	Standard Deviation 57.03
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	45.6 picogram per milliliter (pg/ml)	Standard Deviation 14.6
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H post-dose Day 1	262.6 picogram per milliliter (pg/ml)	Standard Deviation 113.24
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	404.7 picogram per milliliter (pg/ml)	Standard Deviation 84.86
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at day 304/ET	4.8 picogram per milliliter (pg/ml)	Standard Deviation 5.31
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	68.3 picogram per milliliter (pg/ml)	Standard Deviation 29.29
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 154	229.5 picogram per milliliter (pg/ml)	Standard Deviation 29.57
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	144.5 picogram per milliliter (pg/ml)	Standard Deviation 29.38
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	46.9 picogram per milliliter (pg/ml)	Standard Deviation 8.62
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	144.1 picogram per milliliter (pg/ml)	Standard Deviation 35.08
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	75.9 picogram per milliliter (pg/ml)	Standard Deviation 19.03
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	328.4 picogram per milliliter (pg/ml)	Standard Deviation 99.74
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	154.9 picogram per milliliter (pg/ml)	Standard Deviation 49.51
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	180.1 picogram per milliliter (pg/ml)	Standard Deviation 18.23
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	257.7 picogram per milliliter (pg/ml)	Standard Deviation 63.99
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	104.1 picogram per milliliter (pg/ml)	Standard Deviation 21.92
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H post-dose Day 1	193.9 picogram per milliliter (pg/ml)	Standard Deviation 65.55
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	168.9 picogram per milliliter (pg/ml)	Standard Deviation 34.85
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	123.1 picogram per milliliter (pg/ml)	Standard Deviation 23.36
RN6G 15 mg/kg	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	124.9 picogram per milliliter (pg/ml)	Standard Deviation 39.52
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	-26.1 picogram per milliliter (pg/ml)	Standard Deviation 24.22
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H post-dose Day 1	4.0 picogram per milliliter (pg/ml)	Standard Deviation 5.75
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	-13.3 picogram per milliliter (pg/ml)	Standard Deviation 26.69
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	3.9 picogram per milliliter (pg/ml)	Standard Deviation 32
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	9.1 picogram per milliliter (pg/ml)	Standard Deviation 22.03
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	-28.7 picogram per milliliter (pg/ml)	Standard Deviation 31.64
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	8.4 picogram per milliliter (pg/ml)	Standard Deviation 22.71
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	-21.9 picogram per milliliter (pg/ml)	Standard Deviation 27.63
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	-4.3 picogram per milliliter (pg/ml)	Standard Deviation 11.73
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	-12.6 picogram per milliliter (pg/ml)	Standard Deviation 25.16
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	-15.9 picogram per milliliter (pg/ml)	Standard Deviation 28.84
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	-10.5 picogram per milliliter (pg/ml)	Standard Deviation 39.49
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	-22.3 picogram per milliliter (pg/ml)	Standard Deviation 27.87
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 154	-29.3 picogram per milliliter (pg/ml)	Standard Deviation 25.98
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	-14.7 picogram per milliliter (pg/ml)	Standard Deviation 26.98
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	-17.8 picogram per milliliter (pg/ml)	Standard Deviation 28.09
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	-18.8 picogram per milliliter (pg/ml)	Standard Deviation 22.91
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	-19.9 picogram per milliliter (pg/ml)	Standard Deviation 24.25
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	-10.9 picogram per milliliter (pg/ml)	Standard Deviation 43.12
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	-8.5 picogram per milliliter (pg/ml)	Standard Deviation 42.38
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at day 304/ET	-35.9 picogram per milliliter (pg/ml)	Standard Deviation 26.66
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	61.4 picogram per milliliter (pg/ml)	Standard Deviation 31.71
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	-7.7 picogram per milliliter (pg/ml)	Standard Deviation 16.71
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H post-dose Day 1	-4.0 picogram per milliliter (pg/ml)	Standard Deviation 19.86
Placebo	Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	-21.7 picogram per milliliter (pg/ml)	Standard Deviation 25.89

Secondary

Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Amyloid (A) Beta (1-X) is a primary activator of complement in Alzheimer's disease (AD).

Time frame: Baseline, Day 1 (1 hour, 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	62226.8 Picogram per milliliter (pg/ml)	Standard Deviation 17554.96
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	371.8 Picogram per milliliter (pg/ml)	Standard Deviation 284.73
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	25303.0 Picogram per milliliter (pg/ml)	Standard Deviation 4293.92
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	29386.3 Picogram per milliliter (pg/ml)	Standard Deviation 3246.3
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	3340.5 Picogram per milliliter (pg/ml)	Standard Deviation 386.71
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	50269.8 Picogram per milliliter (pg/ml)	Standard Deviation 7129.73
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	17782.7 Picogram per milliliter (pg/ml)	Standard Deviation 4264.51
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	46295.7 Picogram per milliliter (pg/ml)	Standard Deviation 7585.69
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	49017.8 Picogram per milliliter (pg/ml)	Standard Deviation 6793.71
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	27212.1 Picogram per milliliter (pg/ml)	Standard Deviation 12018.62
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	8777.5 Picogram per milliliter (pg/ml)	Standard Deviation 1441.65
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	20950.3 Picogram per milliliter (pg/ml)	Standard Deviation 6951.3
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	33804.2 Picogram per milliliter (pg/ml)	Standard Deviation 5420.83
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4H post-dose Day 1	7850.0 Picogram per milliliter (pg/ml)	Standard Deviation 1490.33
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	41329.3 Picogram per milliliter (pg/ml)	Standard Deviation 12376.68
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	34071.5 Picogram per milliliter (pg/ml)	Standard Deviation 4062.24
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	52558.0 Picogram per milliliter (pg/ml)	Standard Deviation 6374.13
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	51102.8 Picogram per milliliter (pg/ml)	Standard Deviation 6552.83
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	23723.0 Picogram per milliliter (pg/ml)	Standard Deviation 4080.35
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	50329.3 Picogram per milliliter (pg/ml)	Standard Deviation 9389.75
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2H post-dose Day 1	5118.7 Picogram per milliliter (pg/ml)	Standard Deviation 709
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	41991.0 Picogram per milliliter (pg/ml)	Standard Deviation 7209.04
RN6G 5 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	42393.7 Picogram per milliliter (pg/ml)	Standard Deviation 7739.27
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	70846.5 Picogram per milliliter (pg/ml)	Standard Deviation 24378.68
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	102384.7 Picogram per milliliter (pg/ml)	Standard Deviation 17624.73
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	36042.0 Picogram per milliliter (pg/ml)	Standard Deviation 25934.3
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2H post-dose Day 1	4821.2 Picogram per milliliter (pg/ml)	Standard Deviation 1114.32
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	89908.2 Picogram per milliliter (pg/ml)	Standard Deviation 28896.82
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	98349.2 Picogram per milliliter (pg/ml)	Standard Deviation 20226.44
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	114474.3 Picogram per milliliter (pg/ml)	Standard Deviation 28268.9
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	124417.0 Picogram per milliliter (pg/ml)	Standard Deviation 26689.05
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4H post-dose Day 1	6992.7 Picogram per milliliter (pg/ml)	Standard Deviation 1716.83
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	102548.2 Picogram per milliliter (pg/ml)	Standard Deviation 22902.22
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	1596.8 Picogram per milliliter (pg/ml)	Standard Deviation 2794.08
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	103651.8 Picogram per milliliter (pg/ml)	Standard Deviation 27880.97
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	33566.0 Picogram per milliliter (pg/ml)	Standard Deviation 4698.42
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	88678.7 Picogram per milliliter (pg/ml)	Standard Deviation 22431.39
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at day 304/ET	13550.8 Picogram per milliliter (pg/ml)	Standard Deviation 5901.76
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 154	141033.8 Picogram per milliliter (pg/ml)	Standard Deviation 22685.63
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	69611.3 Picogram per milliliter (pg/ml)	Standard Deviation 21077.31
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	121176.2 Picogram per milliliter (pg/ml)	Standard Deviation 34652.27
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	54407.7 Picogram per milliliter (pg/ml)	Standard Deviation 15467.03
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	3205.5 Picogram per milliliter (pg/ml)	Standard Deviation 856.06
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	35848.3 Picogram per milliliter (pg/ml)	Standard Deviation 9540.26
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	107243.5 Picogram per milliliter (pg/ml)	Standard Deviation 28813.61
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	101938.3 Picogram per milliliter (pg/ml)	Standard Deviation 21440.86
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	87735.4 Picogram per milliliter (pg/ml)	Standard Deviation 19304.46
RN6G 10 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	35489.0 Picogram per milliliter (pg/ml)	Standard Deviation 11571.26
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 154	190913.6 Picogram per milliliter (pg/ml)	Standard Deviation 29331.01
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	200.0 Picogram per milliliter (pg/ml)	Standard Deviation 0
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	3947.2 Picogram per milliliter (pg/ml)	Standard Deviation 1822.39
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2H post-dose Day 1	5610.8 Picogram per milliliter (pg/ml)	Standard Deviation 2544.7
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4H post-dose Day 1	7874.3 Picogram per milliliter (pg/ml)	Standard Deviation 2158.56
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	37862.0 Picogram per milliliter (pg/ml)	Standard Deviation 1069.86
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	94017.0 Picogram per milliliter (pg/ml)	Standard Deviation 7060.55
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	80138.0 Picogram per milliliter (pg/ml)	Standard Deviation 13795.55
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	71190.6 Picogram per milliliter (pg/ml)	Standard Deviation 7553.42
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	57701.0 Picogram per milliliter (pg/ml)	Standard Deviation 14705.1
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	110278.0 Picogram per milliliter (pg/ml)	Standard Deviation 20296.92
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	98343.8 Picogram per milliliter (pg/ml)	Standard Deviation 21336.44
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	149272.0 Picogram per milliliter (pg/ml)	Standard Deviation 23898.1
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	120091.6 Picogram per milliliter (pg/ml)	Standard Deviation 5895.1
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	157448.0 Picogram per milliliter (pg/ml)	Standard Deviation 33235.41
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	140917.6 Picogram per milliliter (pg/ml)	Standard Deviation 17498.78
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	168767.8 Picogram per milliliter (pg/ml)	Standard Deviation 7272.93
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	154350.0 Picogram per milliliter (pg/ml)	Standard Deviation 9459.75
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	140246.0 Picogram per milliliter (pg/ml)	Standard Deviation 15770.21
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	136109.5 Picogram per milliliter (pg/ml)	Standard Deviation 12883.65
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	153793.0 Picogram per milliliter (pg/ml)	Standard Deviation 15312.09
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	80464.2 Picogram per milliliter (pg/ml)	Standard Deviation 11546.49
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	161691.4 Picogram per milliliter (pg/ml)	Standard Deviation 21292.74
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	57692.0 Picogram per milliliter (pg/ml)	Standard Deviation 16310.16
RN6G 15 mg/kg	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at day 304/ET	12127.2 Picogram per milliliter (pg/ml)	Standard Deviation 3196.16
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 56	-36.3 Picogram per milliliter (pg/ml)	Standard Deviation 305.27
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1H post-dose Day 1	0.3 Picogram per milliliter (pg/ml)	Standard Deviation 83.39
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2 H Post-dose Day 140	-137.3 Picogram per milliliter (pg/ml)	Standard Deviation 135.93
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 45	-6.5 Picogram per milliliter (pg/ml)	Standard Deviation 209.72
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 28	-69.7 Picogram per milliliter (pg/ml)	Standard Deviation 239.14
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at day 304/ET	-164.3 Picogram per milliliter (pg/ml)	Standard Deviation 167.57
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4 H Post-dose Day 140	-144.2 Picogram per milliliter (pg/ml)	Standard Deviation 158.04
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 19	-62.5 Picogram per milliliter (pg/ml)	Standard Deviation 106.16
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 14	-66.2 Picogram per milliliter (pg/ml)	Standard Deviation 103.72
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 224	-110.3 Picogram per milliliter (pg/ml)	Standard Deviation 138.97
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 141	-11.0 Picogram per milliliter (pg/ml)	Standard Deviation 30.66
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 7	16.8 Picogram per milliliter (pg/ml)	Standard Deviation 52.82
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 103	116.6 Picogram per milliliter (pg/ml)	Standard Deviation 296.52
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 154	-103.5 Picogram per milliliter (pg/ml)	Standard Deviation 85.83
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 2	-9.8 Picogram per milliliter (pg/ml)	Standard Deviation 132.42
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 4H post-dose Day 1	1.7 Picogram per milliliter (pg/ml)	Standard Deviation 225.19
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Baseline	386.5 Picogram per milliliter (pg/ml)	Standard Deviation 174.33
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 131	-61.6 Picogram per milliliter (pg/ml)	Standard Deviation 131.01
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 168	-64.6 Picogram per milliliter (pg/ml)	Standard Deviation 132.4
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at pre-dose Day 140	-3.4 Picogram per milliliter (pg/ml)	Standard Deviation 92.42
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 112	214.4 Picogram per milliliter (pg/ml)	Standard Deviation 342.45
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 84	122.2 Picogram per milliliter (pg/ml)	Standard Deviation 362.01
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 2H post-dose Day 1	45.3 Picogram per milliliter (pg/ml)	Standard Deviation 125.22
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at 1 H post-dose Day 140	-25.0 Picogram per milliliter (pg/ml)	Standard Deviation 80.53
Placebo	Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Change at Day 75	205.6 Picogram per milliliter (pg/ml)	Standard Deviation 302.4

Secondary

Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Time frame: Baseline, Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PT-INR	0.006 Ratio	Standard Deviation 0.0586
RN6G 5 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PT-INR	-0.027 Ratio	Standard Deviation 0.1078
RN6G 5 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PT-INR	0.014 Ratio	Standard Deviation 0.1001
RN6G 5 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PT-INR	-0.022 Ratio	Standard Deviation 0.0256
RN6G 5 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PT-INR	-0.047 Ratio	Standard Deviation 0.0288
RN6G 5 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PT-INR	-0.058 Ratio	Standard Deviation 0.0776
RN6G 5 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PT-INR	0.037 Ratio	Standard Deviation 0.0535
RN6G 5 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PT-INR	0.995 Ratio	Standard Deviation 0.0455
RN6G 10 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PT-INR	-0.008 Ratio	Standard Deviation 0.0488
RN6G 10 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PT-INR	0.972 Ratio	Standard Deviation 0.0436
RN6G 10 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PT-INR	-0.003 Ratio	Standard Deviation 0.0234
RN6G 10 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PT-INR	-0.027 Ratio	Standard Deviation 0.0755
RN6G 10 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PT-INR	0.004 Ratio	Standard Deviation 0.0522
RN6G 10 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PT-INR	0.042 Ratio	Standard Deviation 0.0697
RN6G 10 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PT-INR	-0.005 Ratio	Standard Deviation 0.0912
RN6G 10 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PT-INR	0.047 Ratio	Standard Deviation 0.0344
RN6G 10 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PT-INR	0.085 Ratio	Standard Deviation 0.0599
RN6G 15 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PT-INR	0.096 Ratio	Standard Deviation 0.0623
RN6G 15 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PT-INR	0.140 Ratio	Standard Deviation 0.1231
RN6G 15 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PT-INR	0.064 Ratio	Standard Deviation 0.1199
RN6G 15 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PT-INR	0.106 Ratio	Standard Deviation 0.0669
RN6G 15 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PT-INR	0.098 Ratio	Standard Deviation 0.0519
RN6G 15 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PT-INR	0.933 Ratio	Standard Deviation 0.0871
RN6G 15 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PT-INR	0.055 Ratio	Standard Deviation 0.0481
RN6G 15 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PT-INR	0.060 Ratio	Standard Deviation 0.0651
RN6G 15 mg/kg	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PT-INR	0.117 Ratio	Standard Deviation 0.1076
Placebo	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 56: PT-INR	0.000 Ratio	Standard Deviation 0.1802
Placebo	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: PT-INR	-0.050 Ratio	Standard Deviation 0.1077
Placebo	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 112: PT-INR	-0.062 Ratio	Standard Deviation 0.1284
Placebo	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 84: PT-INR	-0.060 Ratio	Standard Deviation 0.1374
Placebo	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: PT-INR	-0.018 Ratio	Standard Deviation 0.1148
Placebo	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 28: PT-INR	-0.050 Ratio	Standard Deviation 0.0925
Placebo	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 140: PT-INR	-0.006 Ratio	Standard Deviation 0.1757
Placebo	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: PT-INR	1.017 Ratio	Standard Deviation 0.1167
Placebo	Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: PT-INR	0.050 Ratio	Standard Deviation 0.1927

Secondary

Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate

Time frame: Baseline, 1 and 4 H post-dose on Day 1; 24 H post-dose on Days 2 and 141; pre-dose and 4 - 8 H post-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 7, 14, 19, 45, 75, 103;131, 141, 154 168, 224 and 304/ET

Population: Safety analysis set included all randomized participants who received any amount of study drug. Here Number Analyzed signifies number of participants evaluated for given time point.

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Baseline	64.2 Beats per minute	Standard Deviation 6.4
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 56	1.2 Beats per minute	Standard Deviation 2.99
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 112	-0.8 Beats per minute	Standard Deviation 4.02
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose day 56	3.0 Beats per minute	Standard Deviation 4.69
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 75	1.5 Beats per minute	Standard Deviation 4.64
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 103	2.2 Beats per minute	Standard Deviation 2.04
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 84	2.3 Beats per minute	Standard Deviation 3.83
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 1H post-dose Day 1	1.7 Beats per minute	Standard Deviation 2.66
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 84	-0.3 Beats per minute	Standard Deviation 5.89
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 24 H post dose Day 141	1.0 Beats per minute	Standard Deviation 3.22
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 1 H post-dose Day 140	-0.5 Beats per minute	Standard Deviation 4.37
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4 H post-dose Day 1	3.5 Beats per minute	Standard Deviation 6.25
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 224/ET	-1.2 Beats per minute	Standard Deviation 6.94
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 24 H post-dose Day 2	0.8 Beats per minute	Standard Deviation 2.71
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 7	4.5 Beats per minute	Standard Deviation 3.67
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 168	1.7 Beats per minute	Standard Deviation 1.86
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 140	2.5 Beats per minute	Standard Deviation 3.99
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 14	1.2 Beats per minute	Standard Deviation 2.04
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 19	2.5 Beats per minute	Standard Deviation 5.92
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 131	1.8 Beats per minute	Standard Deviation 4.07
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 28	0.2 Beats per minute	Standard Deviation 5.53
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 28	6.5 Beats per minute	Standard Deviation 10.15
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4 H post dose Day 140.	3.2 Beats per minute	Standard Deviation 4.83
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 112	1.8 Beats per minute	Standard Deviation 2.86
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 45	3.5 Beats per minute	Standard Deviation 2.17
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 154	9.2 Beats per minute	Standard Deviation 3.82
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 304/ET	1.2 Beats per minute	Standard Deviation 5.88
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 24 H post-dose Day 2	1.5 Beats per minute	Standard Deviation 1.97
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 112	1.5 Beats per minute	Standard Deviation 3.33
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 224/ET	0.3 Beats per minute	Standard Deviation 5.01
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 56	1.5 Beats per minute	Standard Deviation 4.37
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Baseline	62.8 Beats per minute	Standard Deviation 4.4
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 140	2.8 Beats per minute	Standard Deviation 4.07
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 45	2.3 Beats per minute	Standard Deviation 4.03
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose day 56	2.3 Beats per minute	Standard Deviation 4.13
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 24 H post dose Day 141	8.7 Beats per minute	Standard Deviation 3.88
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 103	2.5 Beats per minute	Standard Deviation 4.09
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 7	3.3 Beats per minute	Standard Deviation 3.08
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 75	5.5 Beats per minute	Standard Deviation 6.19
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 1 H post-dose Day 140	0.8 Beats per minute	Standard Deviation 5.53
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 28	2.2 Beats per minute	Standard Deviation 2.56
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 28	2.3 Beats per minute	Standard Deviation 5.32
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 84	4.0 Beats per minute	Standard Deviation 3.1
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 131	7.2 Beats per minute	Standard Deviation 7.55
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 84	1.8 Beats per minute	Standard Deviation 4.31
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 168	-0.5 Beats per minute	Standard Deviation 4.89
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 1H post-dose Day 1	-1.8 Beats per minute	Standard Deviation 4.4
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 14	4.3 Beats per minute	Standard Deviation 7.39
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4 H post dose Day 140.	4.0 Beats per minute	Standard Deviation 8.94
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 112	3.3 Beats per minute	Standard Deviation 5.05
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4 H post-dose Day 1	1.2 Beats per minute	Standard Deviation 5.81
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 19	7.8 Beats per minute	Standard Deviation 7.6
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 140	-0.8 Beats per minute	Standard Deviation 4.79
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 154	0.5 Beats per minute	Standard Deviation 8.73
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 168	-6.8 Beats per minute	Standard Deviation 5.42
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 224/ET	-0.7 Beats per minute	Standard Deviation 5.99
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 304/ET	-0.2 Beats per minute	Standard Deviation 2.56
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Baseline	66.5 Beats per minute	Standard Deviation 6.53
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 1H post-dose Day 1	-4.2 Beats per minute	Standard Deviation 5.46
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4 H post-dose Day 1	-2.3 Beats per minute	Standard Deviation 7.5
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 24 H post-dose Day 2	-2.0 Beats per minute	Standard Deviation 3.74
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 7	-4.2 Beats per minute	Standard Deviation 5.42
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 14	0.3 Beats per minute	Standard Deviation 4.59
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 19	0.0 Beats per minute	Standard Deviation 2.45
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 28	-1.5 Beats per minute	Standard Deviation 5.72
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 28	-2.8 Beats per minute	Standard Deviation 4.32
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 45	5.2 Beats per minute	Standard Deviation 7.26
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 56	-3.7 Beats per minute	Standard Deviation 5.13
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose day 56	1.6 Beats per minute	Standard Deviation 10.14
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 75	8.0 Beats per minute	Standard Deviation 8.12
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 84	-1.8 Beats per minute	Standard Deviation 4.17
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 84	-2.7 Beats per minute	Standard Deviation 7.76
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 103	1.3 Beats per minute	Standard Deviation 1.63
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 112	-0.2 Beats per minute	Standard Deviation 4.26
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 112	-2.2 Beats per minute	Standard Deviation 3.19
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 131	2.8 Beats per minute	Standard Deviation 13.07
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 1 H post-dose Day 140	-4.5 Beats per minute	Standard Deviation 6.83
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4 H post dose Day 140.	-2.8 Beats per minute	Standard Deviation 6.91
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 24 H post dose Day 141	-2.0 Beats per minute	Standard Deviation 6.1
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 45	-3.0 Beats per minute	Standard Deviation 5.73
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 24 H post dose Day 141	6.4 Beats per minute	Standard Deviation 4.77
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 112	0.2 Beats per minute	Standard Deviation 5.02
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 28	0.3 Beats per minute	Standard Deviation 12.04
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 28	-1.2 Beats per minute	Standard Deviation 2.71
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4 H post dose Day 140.	-1.0 Beats per minute	Standard Deviation 10.2
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 112	-1.6 Beats per minute	Standard Deviation 0.89
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 19	1.0 Beats per minute	Standard Deviation 5.76
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 14	6.0 Beats per minute	Standard Deviation 6.93
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 168	4.8 Beats per minute	Standard Deviation 7.56
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 131	1.8 Beats per minute	Standard Deviation 6.94
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 7	4.2 Beats per minute	Standard Deviation 5.95
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 24 H post-dose Day 2	3.8 Beats per minute	Standard Deviation 6.4
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4 H post-dose Day 1	4.0 Beats per minute	Standard Deviation 7.77
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 140	3.2 Beats per minute	Standard Deviation 3.27
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 1H post-dose Day 1	1.0 Beats per minute	Standard Deviation 8.83
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Baseline	66.7 Beats per minute	Standard Deviation 5.01
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 154	13.5 Beats per minute	Standard Deviation 5
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 1 H post-dose Day 140	-3.2 Beats per minute	Standard Deviation 9.09
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 84	2.2 Beats per minute	Standard Deviation 7.09
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 304/ET	2.0 Beats per minute	Standard Deviation 5.66
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose Day 84	4.2 Beats per minute	Standard Deviation 5.12
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 75	6.8 Beats per minute	Standard Deviation 8.9
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at 4-8 H post-dose day 56	6.0 Beats per minute	Standard Deviation 9.08
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 224/ET	0.5 Beats per minute	Standard Deviation 4.55
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at Day 103	6.0 Beats per minute	Standard Deviation 5.29
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate	Change at pre-dose Day 56	2.0 Beats per minute	Standard Deviation 5.51

Secondary

Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure

Time frame: Baseline, 1 and 4 hour (H) post-dose on Day 1; 24 H post-dose on Days 2 and 141; pre-dose and 4 - 8 H post-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 7, 14, 19, 45, 75, 103;131, 141, 154 168, 224 and 304/ET

Population: Safety analysis set included all randomized participants who received any amount of study drug. Here Number Analyzed signifies number of participants evaluated for given time point.

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 140: DBP	-4.3 millimeter of mercury (mmHg)	Standard Deviation 10.15
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Pre-dose Day 84: SBP	3.2 millimeter of mercury (mmHg)	Standard Deviation 15.05
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 19: SBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 7.45
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 19: DBP	-1.7 millimeter of mercury (mmHg)	Standard Deviation 7.84
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post-dose Day 2: DBP	-2.7 millimeter of mercury (mmHg)	Standard Deviation 8.36
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8H post-dose Day 84: SBP	0.0 millimeter of mercury (mmHg)	Standard Deviation 9.63
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 56: DBP	1.0 millimeter of mercury (mmHg)	Standard Deviation 5.33
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post-dose Day 2: SBP	5.0 millimeter of mercury (mmHg)	Standard Deviation 11.22
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 131: DBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 3.01
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 103: SBP	2.0 millimeter of mercury (mmHg)	Standard Deviation 13.08
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post dose Day 141: DBP	-4.7 millimeter of mercury (mmHg)	Standard Deviation 4.13
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post dose Day 140: SBP	-6.0 millimeter of mercury (mmHg)	Standard Deviation 9.96
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 168: SBP	5.8 millimeter of mercury (mmHg)	Standard Deviation 24.04
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 112: SBP	-2.0 millimeter of mercury (mmHg)	Standard Deviation 12.65
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose day 56: DBP	0.8 millimeter of mercury (mmHg)	Standard Deviation 5
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 28: DBP	-1.0 millimeter of mercury (mmHg)	Standard Deviation 11.51
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 112:DBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 8.16
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 112: SBP	-4.7 millimeter of mercury (mmHg)	Standard Deviation 8.26
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 28: SBP	7.7 millimeter of mercury (mmHg)	Standard Deviation 10.61
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 168: DBP	-2.2 millimeter of mercury (mmHg)	Standard Deviation 6.88
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post dose Day 141: SBP	-6.0 millimeter of mercury (mmHg)	Standard Deviation 11.1
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 131: SBP	4.3 millimeter of mercury (mmHg)	Standard Deviation 13.11
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 224/ET: SBP	1.8 millimeter of mercury (mmHg)	Standard Deviation 15.83
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 7: SBP	7.3 millimeter of mercury (mmHg)	Standard Deviation 22.08
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 112: DBP	-1.8 millimeter of mercury (mmHg)	Standard Deviation 8.35
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 140: SBP	-5.3 millimeter of mercury (mmHg)	Standard Deviation 15.78
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post dose Day 140: DBP	-6.3 millimeter of mercury (mmHg)	Standard Deviation 8.24
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 45: SBP	3.7 millimeter of mercury (mmHg)	Standard Deviation 6.62
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 28: SBP	7.7 millimeter of mercury (mmHg)	Standard Deviation 11.83
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 224/ET: DBP	-0.8 millimeter of mercury (mmHg)	Standard Deviation 8.5
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 14: DBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 6.02
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 103: DBP	-5.0 millimeter of mercury (mmHg)	Standard Deviation 5.76
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 140: SBP	-0.7 millimeter of mercury (mmHg)	Standard Deviation 11.64
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 56: SBP	5.0 millimeter of mercury (mmHg)	Standard Deviation 15.48
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 28:DBP	0.7 millimeter of mercury (mmHg)	Standard Deviation 6.53
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post-dose Day 1: SBP	1.0 millimeter of mercury (mmHg)	Standard Deviation 8.56
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 140: DBP	-2.7 millimeter of mercury (mmHg)	Standard Deviation 7.87
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 14: SBP	2.0 millimeter of mercury (mmHg)	Standard Deviation 15.13
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 84:DBP	-6.7 millimeter of mercury (mmHg)	Standard Deviation 7.97
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Baseline: DBP	78.7 millimeter of mercury (mmHg)	Standard Deviation 7.55
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose day 56: SBP	4.8 millimeter of mercury (mmHg)	Standard Deviation 10.82
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 7: DBP	-1.7 millimeter of mercury (mmHg)	Standard Deviation 11.48
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1H post-dose Day 1: SBP	11.3 millimeter of mercury (mmHg)	Standard Deviation 10.71
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 1: DBP	-0.3 millimeter of mercury (mmHg)	Standard Deviation 7.09
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 75: DBP	-0.3 millimeter of mercury (mmHg)	Standard Deviation 6.12
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 75: SBP	-0.7 millimeter of mercury (mmHg)	Standard Deviation 19.34
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 84: DBP	-0.7 millimeter of mercury (mmHg)	Standard Deviation 8.45
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post-dose Day 1: DBP	-3.7 millimeter of mercury (mmHg)	Standard Deviation 11.48
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 45: DBP	1.7 millimeter of mercury (mmHg)	Standard Deviation 5.99
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Baseline: SBP	128.0 millimeter of mercury (mmHg)	Standard Deviation 10.58
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 1: DBP	3.5 millimeter of mercury (mmHg)	Standard Deviation 9.38
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 224/ET: DBP	1.0 millimeter of mercury (mmHg)	Standard Deviation 8
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post-dose Day 1: DBP	-1.5 millimeter of mercury (mmHg)	Standard Deviation 8.09
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 154: SBP	-2.7 millimeter of mercury (mmHg)	Standard Deviation 8.8
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post dose Day 141: DBP	2.2 millimeter of mercury (mmHg)	Standard Deviation 12.04
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post-dose Day 2: DBP	-0.7 millimeter of mercury (mmHg)	Standard Deviation 5.32
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post dose Day 141: SBP	-2.5 millimeter of mercury (mmHg)	Standard Deviation 10.43
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 7: DBP	4.7 millimeter of mercury (mmHg)	Standard Deviation 8.26
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 19: SBP	-6.2 millimeter of mercury (mmHg)	Standard Deviation 9.43
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 14: DBP	3.7 millimeter of mercury (mmHg)	Standard Deviation 9.91
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post dose Day 140: SBP	-6.7 millimeter of mercury (mmHg)	Standard Deviation 16.44
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 19: DBP	-1.2 millimeter of mercury (mmHg)	Standard Deviation 6.59
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 28: DBP	-2.2 millimeter of mercury (mmHg)	Standard Deviation 8.95
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 75: DBP	-3.2 millimeter of mercury (mmHg)	Standard Deviation 10.01
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 28:DBP	0.0 millimeter of mercury (mmHg)	Standard Deviation 12.9
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 28: SBP	-8.8 millimeter of mercury (mmHg)	Standard Deviation 10.09
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 45: DBP	5.8 millimeter of mercury (mmHg)	Standard Deviation 11.74
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1H post-dose Day 1: SBP	-5.7 millimeter of mercury (mmHg)	Standard Deviation 16.56
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 168: SBP	-0.8 millimeter of mercury (mmHg)	Standard Deviation 11.18
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 56: DBP	0.3 millimeter of mercury (mmHg)	Standard Deviation 10.98
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post dose Day 140: DBP	3.3 millimeter of mercury (mmHg)	Standard Deviation 9.2
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose day 56: DBP	-0.5 millimeter of mercury (mmHg)	Standard Deviation 11.93
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 28: SBP	-5.5 millimeter of mercury (mmHg)	Standard Deviation 12.29
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 45: SBP	0.3 millimeter of mercury (mmHg)	Standard Deviation 12.31
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 140: DBP	4.2 millimeter of mercury (mmHg)	Standard Deviation 10.82
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 56: SBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 9.61
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose day 56: SBP	-1.7 millimeter of mercury (mmHg)	Standard Deviation 7.34
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post-dose Day 1: SBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 17.42
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 140: DBP	2.5 millimeter of mercury (mmHg)	Standard Deviation 11.2
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 75: SBP	-1.8 millimeter of mercury (mmHg)	Standard Deviation 16.57
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Pre-dose Day 84: SBP	-0.8 millimeter of mercury (mmHg)	Standard Deviation 8.91
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 168: DBP	0.0 millimeter of mercury (mmHg)	Standard Deviation 11.51
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 131: DBP	-1.7 millimeter of mercury (mmHg)	Standard Deviation 8.48
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8H post-dose Day 84: SBP	-7.0 millimeter of mercury (mmHg)	Standard Deviation 12.62
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 103: SBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 11.29
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post-dose Day 2: SBP	-10.7 millimeter of mercury (mmHg)	Standard Deviation 18.53
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 112:DBP	0.0 millimeter of mercury (mmHg)	Standard Deviation 10.73
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 112: SBP	-1.2 millimeter of mercury (mmHg)	Standard Deviation 17.28
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Baseline: SBP	128.7 millimeter of mercury (mmHg)	Standard Deviation 18.05
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 112: SBP	-2.7 millimeter of mercury (mmHg)	Standard Deviation 10.25
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 112: DBP	3.3 millimeter of mercury (mmHg)	Standard Deviation 10.8
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 131: SBP	0.2 millimeter of mercury (mmHg)	Standard Deviation 12.59
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 140: SBP	-2.3 millimeter of mercury (mmHg)	Standard Deviation 16.42
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 7: SBP	-5.3 millimeter of mercury (mmHg)	Standard Deviation 15.47
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 103: DBP	0.3 millimeter of mercury (mmHg)	Standard Deviation 12.23
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 224/ET: SBP	4.7 millimeter of mercury (mmHg)	Standard Deviation 14.88
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 304/ET: DBP	1.3 millimeter of mercury (mmHg)	Standard Deviation 11.57
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 140: SBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 12.75
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 154: DBP	2.5 millimeter of mercury (mmHg)	Standard Deviation 8.85
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 84:DBP	-3.0 millimeter of mercury (mmHg)	Standard Deviation 8.07
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 304/ET: SBP	-1.7 millimeter of mercury (mmHg)	Standard Deviation 9.07
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Baseline: DBP	75.0 millimeter of mercury (mmHg)	Standard Deviation 10.56
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 14: SBP	-1.5 millimeter of mercury (mmHg)	Standard Deviation 9.29
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 84: DBP	0.8 millimeter of mercury (mmHg)	Standard Deviation 14.76
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 168: SBP	-11.8 millimeter of mercury (mmHg)	Standard Deviation 7.96
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Baseline: SBP	127.3 millimeter of mercury (mmHg)	Standard Deviation 7.37
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1H post-dose Day 1: SBP	3.8 millimeter of mercury (mmHg)	Standard Deviation 11.7
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post-dose Day 1: SBP	2.2 millimeter of mercury (mmHg)	Standard Deviation 9.64
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post-dose Day 2: SBP	-5.0 millimeter of mercury (mmHg)	Standard Deviation 8.29
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 7: SBP	-1.5 millimeter of mercury (mmHg)	Standard Deviation 7.74
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 14: SBP	-7.2 millimeter of mercury (mmHg)	Standard Deviation 11.84
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 19: SBP	-8.6 millimeter of mercury (mmHg)	Standard Deviation 8.35
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 28: SBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 11.76
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 28: SBP	3.6 millimeter of mercury (mmHg)	Standard Deviation 11.8
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 45: SBP	-1.6 millimeter of mercury (mmHg)	Standard Deviation 23.42
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 56: SBP	-4.5 millimeter of mercury (mmHg)	Standard Deviation 14.71
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose day 56: SBP	-0.2 millimeter of mercury (mmHg)	Standard Deviation 11.58
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 75: SBP	1.8 millimeter of mercury (mmHg)	Standard Deviation 15.88
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Pre-dose Day 84: SBP	-0.3 millimeter of mercury (mmHg)	Standard Deviation 15.88
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8H post-dose Day 84: SBP	3.8 millimeter of mercury (mmHg)	Standard Deviation 10.3
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 103: SBP	5.5 millimeter of mercury (mmHg)	Standard Deviation 8.62
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 112: SBP	-0.5 millimeter of mercury (mmHg)	Standard Deviation 10.35
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 112: SBP	-1.7 millimeter of mercury (mmHg)	Standard Deviation 11.64
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 131: SBP	1.0 millimeter of mercury (mmHg)	Standard Deviation 9.75
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 140: SBP	-2.8 millimeter of mercury (mmHg)	Standard Deviation 8.16
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 224/ET: SBP	-3.0 millimeter of mercury (mmHg)	Standard Deviation 12.81
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 140: SBP	-1.0 millimeter of mercury (mmHg)	Standard Deviation 13.71
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 304/ET: SBP	0.5 millimeter of mercury (mmHg)	Standard Deviation 18.57
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Baseline: DBP	80.3 millimeter of mercury (mmHg)	Standard Deviation 7.74
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 1: DBP	3.0 millimeter of mercury (mmHg)	Standard Deviation 8.44
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post-dose Day 1: DBP	0.2 millimeter of mercury (mmHg)	Standard Deviation 8.01
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post-dose Day 2: DBP	-4.7 millimeter of mercury (mmHg)	Standard Deviation 8.8
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 7: DBP	-2.7 millimeter of mercury (mmHg)	Standard Deviation 9.44
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 14: DBP	-3.7 millimeter of mercury (mmHg)	Standard Deviation 10.63
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 19: DBP	-5.4 millimeter of mercury (mmHg)	Standard Deviation 4.45
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 28: DBP	-2.8 millimeter of mercury (mmHg)	Standard Deviation 11.72
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 28:DBP	2.6 millimeter of mercury (mmHg)	Standard Deviation 4.22
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 45: DBP	-4.6 millimeter of mercury (mmHg)	Standard Deviation 11.99
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 56: DBP	-1.0 millimeter of mercury (mmHg)	Standard Deviation 5.06
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose day 56: DBP	1.4 millimeter of mercury (mmHg)	Standard Deviation 7.2
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post dose Day 140: SBP	-3.3 millimeter of mercury (mmHg)	Standard Deviation 8.57
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post dose Day 141: SBP	-0.7 millimeter of mercury (mmHg)	Standard Deviation 3.33
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 154: SBP	-6.7 millimeter of mercury (mmHg)	Standard Deviation 8.24
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 75: DBP	-4.6 millimeter of mercury (mmHg)	Standard Deviation 5.59
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 84: DBP	-1.2 millimeter of mercury (mmHg)	Standard Deviation 11.39
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 84:DBP	0.5 millimeter of mercury (mmHg)	Standard Deviation 10.25
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 103: DBP	2.2 millimeter of mercury (mmHg)	Standard Deviation 7.96
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 112: DBP	-2.3 millimeter of mercury (mmHg)	Standard Deviation 5.01
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 112:DBP	-1.0 millimeter of mercury (mmHg)	Standard Deviation 6.93
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 131: DBP	-3.4 millimeter of mercury (mmHg)	Standard Deviation 8.99
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 140: DBP	1.0 millimeter of mercury (mmHg)	Standard Deviation 14.52
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 140: DBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 10.19
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post dose Day 140: DBP	-6.5 millimeter of mercury (mmHg)	Standard Deviation 8.24
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post dose Day 141: DBP	-4.5 millimeter of mercury (mmHg)	Standard Deviation 7.09
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 154: DBP	-5.5 millimeter of mercury (mmHg)	Standard Deviation 5.79
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 168: DBP	-4.8 millimeter of mercury (mmHg)	Standard Deviation 7
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 224/ET: DBP	-3.0 millimeter of mercury (mmHg)	Standard Deviation 4.52
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 304/ET: DBP	1.2 millimeter of mercury (mmHg)	Standard Deviation 16.41
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 1: DBP	-3.3 millimeter of mercury (mmHg)	Standard Deviation 7.26
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Baseline: DBP	76.7 millimeter of mercury (mmHg)	Standard Deviation 5.99
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 7: SBP	-4.0 millimeter of mercury (mmHg)	Standard Deviation 4.15
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 84: DBP	2.2 millimeter of mercury (mmHg)	Standard Deviation 7.66
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 304/ET: SBP	2.3 millimeter of mercury (mmHg)	Standard Deviation 15.52
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 140: SBP	5.4 millimeter of mercury (mmHg)	Standard Deviation 20.51
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 224/ET: DBP	-0.5 millimeter of mercury (mmHg)	Standard Deviation 5.96
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 84:DBP	-2.0 millimeter of mercury (mmHg)	Standard Deviation 6.67
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 224/ET: SBP	5.5 millimeter of mercury (mmHg)	Standard Deviation 9.93
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 140: SBP	2.6 millimeter of mercury (mmHg)	Standard Deviation 8.56
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 154: DBP	-4.0 millimeter of mercury (mmHg)	Standard Deviation 4.97
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 103: DBP	3.4 millimeter of mercury (mmHg)	Standard Deviation 4.04
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 131: SBP	12.2 millimeter of mercury (mmHg)	Standard Deviation 13.2
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 112: SBP	7.4 millimeter of mercury (mmHg)	Standard Deviation 14.62
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post-dose Day 2: SBP	0.8 millimeter of mercury (mmHg)	Standard Deviation 4.62
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 112: DBP	4.4 millimeter of mercury (mmHg)	Standard Deviation 4.39
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 112: SBP	12.8 millimeter of mercury (mmHg)	Standard Deviation 8.87
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 103: SBP	11.4 millimeter of mercury (mmHg)	Standard Deviation 12.03
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post-dose Day 1: SBP	2.7 millimeter of mercury (mmHg)	Standard Deviation 12.55
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 112:DBP	1.0 millimeter of mercury (mmHg)	Standard Deviation 7.55
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8H post-dose Day 84: SBP	7.0 millimeter of mercury (mmHg)	Standard Deviation 13.58
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Pre-dose Day 84: SBP	10.0 millimeter of mercury (mmHg)	Standard Deviation 9.67
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 168: SBP	5.2 millimeter of mercury (mmHg)	Standard Deviation 11.12
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 131: DBP	0.0 millimeter of mercury (mmHg)	Standard Deviation 5.34
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 75: SBP	6.0 millimeter of mercury (mmHg)	Standard Deviation 11.77
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose day 56: SBP	8.2 millimeter of mercury (mmHg)	Standard Deviation 17.48
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 168: DBP	1.0 millimeter of mercury (mmHg)	Standard Deviation 5.92
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 140: DBP	-0.4 millimeter of mercury (mmHg)	Standard Deviation 5.32
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 56: SBP	3.2 millimeter of mercury (mmHg)	Standard Deviation 9.52
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 45: SBP	4.3 millimeter of mercury (mmHg)	Standard Deviation 7.12
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1H post-dose Day 1: SBP	2.5 millimeter of mercury (mmHg)	Standard Deviation 6.38
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 1 H post-dose Day 140: DBP	-2.2 millimeter of mercury (mmHg)	Standard Deviation 6.22
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 28: SBP	7.3 millimeter of mercury (mmHg)	Standard Deviation 18.69
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 28: SBP	-0.3 millimeter of mercury (mmHg)	Standard Deviation 9.56
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Baseline: SBP	125.3 millimeter of mercury (mmHg)	Standard Deviation 12.19
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post dose Day 140: DBP	-2.2 millimeter of mercury (mmHg)	Standard Deviation 5.22
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose day 56: DBP	-3.0 millimeter of mercury (mmHg)	Standard Deviation 6.44
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 56: DBP	2.3 millimeter of mercury (mmHg)	Standard Deviation 8.73
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 45: DBP	-2.0 millimeter of mercury (mmHg)	Standard Deviation 10.97
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4-8 H post-dose Day 28:DBP	-4.5 millimeter of mercury (mmHg)	Standard Deviation 7.15
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at pre-dose Day 28: DBP	-4.8 millimeter of mercury (mmHg)	Standard Deviation 8.16
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 19: DBP	-3.7 millimeter of mercury (mmHg)	Standard Deviation 6.83
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 14: DBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 6.06
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 19: SBP	-1.3 millimeter of mercury (mmHg)	Standard Deviation 3.2
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post dose Day 140: SBP	12.4 millimeter of mercury (mmHg)	Standard Deviation 7.44
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 7: DBP	-2.3 millimeter of mercury (mmHg)	Standard Deviation 6.47
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post-dose Day 2: DBP	-2.2 millimeter of mercury (mmHg)	Standard Deviation 8.82
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 14: SBP	2.8 millimeter of mercury (mmHg)	Standard Deviation 7.49
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post dose Day 141: SBP	10.2 millimeter of mercury (mmHg)	Standard Deviation 11.99
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 4 H post-dose Day 1: DBP	-4.3 millimeter of mercury (mmHg)	Standard Deviation 4.03
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 304/ET: DBP	2.8 millimeter of mercury (mmHg)	Standard Deviation 4.99
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 154: SBP	0.3 millimeter of mercury (mmHg)	Standard Deviation 7.41
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at 24 H post dose Day 141: DBP	0.6 millimeter of mercury (mmHg)	Standard Deviation 6.73
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure	Change at Day 75: DBP	-1.2 millimeter of mercury (mmHg)	Standard Deviation 6.53

Secondary

Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature

Population: Safety analysis set included all randomized participants who received any amount of study drug. Here Number Analyzed signifies number of participants evaluated for given time point.

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 24 H post dose Day 141	0.00 Degree Celsius	Standard Deviation 0.21
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 75	-0.15 Degree Celsius	Standard Deviation 0.437
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose day 56	0.22 Degree Celsius	Standard Deviation 0.313
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 28	0.18 Degree Celsius	Standard Deviation 0.204
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4 H post dose Day 140	0.23 Degree Celsius	Standard Deviation 0.197
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 56	0.05 Degree Celsius	Standard Deviation 0.476
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 45	0.13 Degree Celsius	Standard Deviation 0.413
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 28	0.28 Degree Celsius	Standard Deviation 0.172
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4 H post-dose Day 1	0.18 Degree Celsius	Standard Deviation 0.571
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 168	0.27 Degree Celsius	Standard Deviation 0.459
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 1 H post-dose Day 140	0.02 Degree Celsius	Standard Deviation 0.496
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 140	0.10 Degree Celsius	Standard Deviation 0.352
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 24 H post-dose Day 2	0.22 Degree Celsius	Standard Deviation 0.204
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Baseline	36.40 Degree Celsius	Standard Deviation 0.228
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 131	0.18 Degree Celsius	Standard Deviation 0.387
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 112	0.03 Degree Celsius	Standard Deviation 0.437
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 7	0.15 Degree Celsius	Standard Deviation 0.226
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 1H post-dose Day 1	0.30 Degree Celsius	Standard Deviation 0.405
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 112	-0.08 Degree Celsius	Standard Deviation 0.512
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 103	0.05 Degree Celsius	Standard Deviation 0.394
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 14	0.37 Degree Celsius	Standard Deviation 0.35
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 224/ET	0.03 Degree Celsius	Standard Deviation 0.446
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 84	-0.13 Degree Celsius	Standard Deviation 0.665
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 84	-0.03 Degree Celsius	Standard Deviation 0.216
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 19	0.43 Degree Celsius	Standard Deviation 0.234
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 24 H post-dose Day 2	0.12 Degree Celsius	Standard Deviation 0.232
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Baseline	36.72 Degree Celsius	Standard Deviation 0.256
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 1H post-dose Day 1	0.10 Degree Celsius	Standard Deviation 0.253
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4 H post-dose Day 1	0.08 Degree Celsius	Standard Deviation 0.133
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 7	0.05 Degree Celsius	Standard Deviation 0.315
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 14	-0.03 Degree Celsius	Standard Deviation 0.327
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 19	-0.12 Degree Celsius	Standard Deviation 0.271
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 28	-0.10 Degree Celsius	Standard Deviation 0.283
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 28	0.15 Degree Celsius	Standard Deviation 0.339
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 45	0.12 Degree Celsius	Standard Deviation 0.483
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 56	0.08 Degree Celsius	Standard Deviation 0.366
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose day 56	0.13 Degree Celsius	Standard Deviation 0.273
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 75	0.07 Degree Celsius	Standard Deviation 0.333
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 84	-0.03 Degree Celsius	Standard Deviation 0.32
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 84	0.00 Degree Celsius	Standard Deviation 0.167
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 103	-0.08 Degree Celsius	Standard Deviation 0.462
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 112	0.12 Degree Celsius	Standard Deviation 0.279
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 112	0.12 Degree Celsius	Standard Deviation 0.387
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 131	0.02 Degree Celsius	Standard Deviation 0.458
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 140	-0.05 Degree Celsius	Standard Deviation 0.432
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 1 H post-dose Day 140	0.08 Degree Celsius	Standard Deviation 0.407
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4 H post dose Day 140	0.05 Degree Celsius	Standard Deviation 0.428
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 24 H post dose Day 141	0.08 Degree Celsius	Standard Deviation 0.248
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 154	0.07 Degree Celsius	Standard Deviation 0.266
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 168	-0.12 Degree Celsius	Standard Deviation 0.293
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 224/ET	0.07 Degree Celsius	Standard Deviation 0.234
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 304/ET	-0.10 Degree Celsius	Standard Deviation 0.283
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 7	-0.40 Degree Celsius	Standard Deviation 0.405
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 84	0.02 Degree Celsius	Standard Deviation 0.147
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 14	0.08 Degree Celsius	Standard Deviation 0.117
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 154	-0.25 Degree Celsius	Standard Deviation 0.414
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 84	0.03 Degree Celsius	Standard Deviation 0.103
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 103	-0.10 Degree Celsius	Standard Deviation 0.219
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 112	-0.15 Degree Celsius	Standard Deviation 0.274
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 112	-0.22 Degree Celsius	Standard Deviation 0.293
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 24 H post-dose Day 2	-0.32 Degree Celsius	Standard Deviation 0.371
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 168	-0.18 Degree Celsius	Standard Deviation 0.264
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 131	-0.14 Degree Celsius	Standard Deviation 0.288
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 140	-0.07 Degree Celsius	Standard Deviation 0.207
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4 H post-dose Day 1	0.03 Degree Celsius	Standard Deviation 0.207
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Baseline	36.87 Degree Celsius	Standard Deviation 0.082
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 1 H post-dose Day 140	-0.03 Degree Celsius	Standard Deviation 0.197
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 304/ET	-0.10 Degree Celsius	Standard Deviation 0.167
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4 H post dose Day 140	-0.12 Degree Celsius	Standard Deviation 0.248
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 28	0.00 Degree Celsius	Standard Deviation 0.158
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 1H post-dose Day 1	-0.10 Degree Celsius	Standard Deviation 0.19
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 45	-0.06 Degree Celsius	Standard Deviation 0.195
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 28	-0.02 Degree Celsius	Standard Deviation 0.172
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 224/ET	-0.07 Degree Celsius	Standard Deviation 0.288
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 56	0.03 Degree Celsius	Standard Deviation 0.175
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 24 H post dose Day 141	-0.18 Degree Celsius	Standard Deviation 0.183
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose day 56	0.12 Degree Celsius	Standard Deviation 0.084
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 19	0.04 Degree Celsius	Standard Deviation 0.288
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 75	-0.06 Degree Celsius	Standard Deviation 0.279
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 140	-0.02 Degree Celsius	Standard Deviation 0.311
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 224/ET	0.03 Degree Celsius	Standard Deviation 0.472
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 56	0.07 Degree Celsius	Standard Deviation 0.35
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 84	-0.10 Degree Celsius	Standard Deviation 0.4
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 19	-0.02 Degree Celsius	Standard Deviation 0.183
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 45	0.03 Degree Celsius	Standard Deviation 0.516
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 1 H post-dose Day 140	-0.30 Degree Celsius	Standard Deviation 0.224
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 84	0.10 Degree Celsius	Standard Deviation 0.274
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 7	0.00 Degree Celsius	Standard Deviation 0.276
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 154	0.00 Degree Celsius	Standard Deviation 0.141
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 1H post-dose Day 1	0.08 Degree Celsius	Standard Deviation 0.183
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 103	-0.06 Degree Celsius	Standard Deviation 0.251
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 14	0.05 Degree Celsius	Standard Deviation 0.243
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Baseline	36.72 Degree Celsius	Standard Deviation 0.397
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 75	-0.28 Degree Celsius	Standard Deviation 0.383
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 112	-0.20 Degree Celsius	Standard Deviation 0.292
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 24 H post-dose Day 2	-0.08 Degree Celsius	Standard Deviation 0.515
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 304/ET	-0.08 Degree Celsius	Standard Deviation 0.15
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 24 H post dose Day 141	-0.14 Degree Celsius	Standard Deviation 0.365
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 112	0.06 Degree Celsius	Standard Deviation 0.336
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4 H post dose Day 140	-0.14 Degree Celsius	Standard Deviation 0.27
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose day 56	0.00 Degree Celsius	Standard Deviation 0.436
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4-8 H post-dose Day 28	0.03 Degree Celsius	Standard Deviation 0.186
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 131	-0.04 Degree Celsius	Standard Deviation 0.261
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at 4 H post-dose Day 1	0.17 Degree Celsius	Standard Deviation 0.327
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at Day 168	0.12 Degree Celsius	Standard Deviation 0.192
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature	Change at pre-dose Day 28	-0.17 Degree Celsius	Standard Deviation 0.294

Secondary

Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight

Population: Safety analysis set included all randomized participants who received any amount of study drug. Here Number Analyzed signifies number of participants evaluated for given time point.

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 103	-0.60 Kilogram	Standard Deviation 4.787
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 140	1.06 Kilogram	Standard Deviation 0.833
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 112	0.67 Kilogram	Standard Deviation 1.118
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 28	0.46 Kilogram	Standard Deviation 0.749
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 131	1.35 Kilogram	Standard Deviation 1.354
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 224/ ET	0.85 Kilogram	Standard Deviation 0.976
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 45	0.71 Kilogram	Standard Deviation 1.654
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Baseline	81.74 Kilogram	Standard Deviation 9.975
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 56	0.72 Kilogram	Standard Deviation 1.425
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 19	0.25 Kilogram	Standard Deviation 0.709
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 168	1.74 Kilogram	Standard Deviation 2.723
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 75	0.60 Kilogram	Standard Deviation 1.464
RN6G 5 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 84	0.63 Kilogram	Standard Deviation 1.538
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 45	-0.49 Kilogram	Standard Deviation 2.298
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 19	-0.05 Kilogram	Standard Deviation 1.588
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 168	-1.35 Kilogram	Standard Deviation 4.393
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 103	-0.75 Kilogram	Standard Deviation 3.213
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 224/ ET	-1.97 Kilogram	Standard Deviation 4.284
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 154	-3.78 Kilogram	Standard Deviation 8.246
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 56	-0.99 Kilogram	Standard Deviation 2.371
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 112	0.05 Kilogram	Standard Deviation 3.638
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 140	-0.36 Kilogram	Standard Deviation 4.233
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 131	-0.43 Kilogram	Standard Deviation 4.197
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 84	-0.54 Kilogram	Standard Deviation 3.194
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 28	-0.12 Kilogram	Standard Deviation 2.098
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 304/ET	0.71 Kilogram	Standard Deviation 6.545
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Baseline	85.85 Kilogram	Standard Deviation 8.443
RN6G 10 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 75	-0.46 Kilogram	Standard Deviation 3.267
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 45	0.52 Kilogram	Standard Deviation 0.899
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Baseline	78.58 Kilogram	Standard Deviation 12.497
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 19	0.09 Kilogram	Standard Deviation 1.33
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 28	0.02 Kilogram	Standard Deviation 1.172
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 56	-1.21 Kilogram	Standard Deviation 2.942
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 75	0.48 Kilogram	Standard Deviation 0.883
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 84	-0.16 Kilogram	Standard Deviation 0.943
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 103	0.22 Kilogram	Standard Deviation 1.249
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 112	-0.05 Kilogram	Standard Deviation 0.731
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 131	-0.08 Kilogram	Standard Deviation 0.646
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 140	-0.46 Kilogram	Standard Deviation 1.248
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 154	-0.57 Kilogram	Standard Deviation 1.301
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 168	-0.84 Kilogram	Standard Deviation 1.237
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 224/ ET	1.49 Kilogram	Standard Deviation 4.376
RN6G 15 mg/kg	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 304/ET	3.04 Kilogram	Standard Deviation 4.327
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 140	1.37 Kilogram	Standard Deviation 1.708
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 75	0.98 Kilogram	Standard Deviation 0.641
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 224/ ET	1.42 Kilogram	Standard Deviation 1.679
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 154	1.03 Kilogram	Standard Deviation 1.464
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 56	0.52 Kilogram	Standard Deviation 0.616
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 45	0.36 Kilogram	Standard Deviation 1.219
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Baseline	80.14 Kilogram	Standard Deviation 21.43
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 168	1.26 Kilogram	Standard Deviation 1.312
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 28	0.29 Kilogram	Standard Deviation 0.661
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 112	1.43 Kilogram	Standard Deviation 1.097
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 19	0.93 Kilogram	Standard Deviation 0.945
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 131	1.67 Kilogram	Standard Deviation 1.159
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 103	1.23 Kilogram	Standard Deviation 1.49
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 84	0.99 Kilogram	Standard Deviation 1.05
Placebo	Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight	Change at Day 304/ET	0.60 Kilogram	Standard Deviation 0.678

Secondary

Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET

QT interval corrected using the Fridericia formula (QTcF) \>=500 msec; Maximum Change from Baseline in QTcF at Borderline \>=30 msec to \<60 msec and Prolonged \>=60 msec.

Time frame: Baseline, 1 and 4 H post-dose on Day 1; pre-dose on Days 28, 56, 84, 112; pre-dose and 1, 4 H post-dose on Day 140; Day 168, 224 and 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QTcF	-5.22 Millisecond (msec)	Standard Deviation 8.005
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QTcF	-2.67 Millisecond (msec)	Standard Deviation 7.598
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QTcF	1.50 Millisecond (msec)	Standard Deviation 14.898
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QTcF	-3.17 Millisecond (msec)	Standard Deviation 7.001
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QTcF	-2.28 Millisecond (msec)	Standard Deviation 9.488
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QTcF	-4.39 Millisecond (msec)	Standard Deviation 6.533
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QTcF	-4.72 Millisecond (msec)	Standard Deviation 15.874
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QTcF	0.56 Millisecond (msec)	Standard Deviation 8.035
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QTcF	-2.22 Millisecond (msec)	Standard Deviation 13.404
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QTcF	-8.56 Millisecond (msec)	Standard Deviation 16.363
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QTcF	-1.39 Millisecond (msec)	Standard Deviation 10.438
RN6G 5 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QTcF	414.22 Millisecond (msec)	Standard Deviation 13.474
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QTcF	427.89 Millisecond (msec)	Standard Deviation 21.462
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QTcF	-12.06 Millisecond (msec)	Standard Deviation 14.565
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QTcF	-11.22 Millisecond (msec)	Standard Deviation 11.485
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QTcF	-3.28 Millisecond (msec)	Standard Deviation 8.51
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QTcF	-5.89 Millisecond (msec)	Standard Deviation 10.681
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QTcF	-0.11 Millisecond (msec)	Standard Deviation 8.614
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QTcF	-1.22 Millisecond (msec)	Standard Deviation 12.523
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QTcF	-9.72 Millisecond (msec)	Standard Deviation 14.22
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QTcF	-6.06 Millisecond (msec)	Standard Deviation 9.799
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QTcF	-15.83 Millisecond (msec)	Standard Deviation 36.907
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QTcF	-8.78 Millisecond (msec)	Standard Deviation 13.48
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QTcF	-6.72 Millisecond (msec)	Standard Deviation 14.685
RN6G 10 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QTcF	-1.50 Millisecond (msec)	Standard Deviation 4.732
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QTcF	12.72 Millisecond (msec)	Standard Deviation 8.172
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QTcF	420.56 Millisecond (msec)	Standard Deviation 20.579
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QTcF	3.06 Millisecond (msec)	Standard Deviation 8.762
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QTcF	1.50 Millisecond (msec)	Standard Deviation 13.328
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QTcF	1.78 Millisecond (msec)	Standard Deviation 15.022
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QTcF	7.11 Millisecond (msec)	Standard Deviation 19.452
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QTcF	6.11 Millisecond (msec)	Standard Deviation 20.435
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QTcF	0.78 Millisecond (msec)	Standard Deviation 8.275
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QTcF	8.61 Millisecond (msec)	Standard Deviation 7.672
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QTcF	10.61 Millisecond (msec)	Standard Deviation 11.174
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QTcF	7.94 Millisecond (msec)	Standard Deviation 18.671
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QTcF	1.94 Millisecond (msec)	Standard Deviation 16.996
RN6G 15 mg/kg	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QTcF	-7.39 Millisecond (msec)	Standard Deviation 21.754
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 84: QTcF	19.00 Millisecond (msec)	Standard Deviation 24.226
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post dose Day 140: QTcF	11.60 Millisecond (msec)	Standard Deviation 19.991
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 56: QTcF	6.44 Millisecond (msec)	Standard Deviation 15.93
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 28: QTcF	-2.06 Millisecond (msec)	Standard Deviation 8.41
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Baseline: QTcF	412.06 Millisecond (msec)	Standard Deviation 20.201
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 168: QTcF	8.40 Millisecond (msec)	Standard Deviation 21.483
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 4 H post-dose Day 1: QTcF	9.50 Millisecond (msec)	Standard Deviation 28.659
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 1: QTcF	3.86 Millisecond (msec)	Standard Deviation 13.329
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 304/ET: QTcF	11.50 Millisecond (msec)	Standard Deviation 18.165
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at Day 224/ET: QTcF	10.94 Millisecond (msec)	Standard Deviation 17.055
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at 1 H post-dose Day 140: QTcF	14.13 Millisecond (msec)	Standard Deviation 15.604
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 140: QTcF	8.87 Millisecond (msec)	Standard Deviation 23.092
Placebo	Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET	Change at pre-dose Day 112: QTcF	25.80 Millisecond (msec)	Standard Deviation 39.012

Secondary

Maximum Observed Plasma Concentration (Cmax) of RN6G (PF-04382923)

Time frame: Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 168, 336 hours on Day 1 and 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140

Population: All randomized participants who met the inclusion criteria and received any amount of study drug were included. Here Overall Number of participants Analyzed signifies number of participants evaluable for this outcome measure.

Arm	Measure	Group	Value (GEOMETRIC_MEAN)	Dispersion
RN6G 5 mg/kg	Maximum Observed Plasma Concentration (Cmax) of RN6G (PF-04382923)	Day 1	142.9 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 12
RN6G 5 mg/kg	Maximum Observed Plasma Concentration (Cmax) of RN6G (PF-04382923)	Day 140	185.1 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 16
RN6G 10 mg/kg	Maximum Observed Plasma Concentration (Cmax) of RN6G (PF-04382923)	Day 140	439.8 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 15
RN6G 10 mg/kg	Maximum Observed Plasma Concentration (Cmax) of RN6G (PF-04382923)	Day 1	283.4 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 18
RN6G 15 mg/kg	Maximum Observed Plasma Concentration (Cmax) of RN6G (PF-04382923)	Day 1	524.1 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 66
RN6G 15 mg/kg	Maximum Observed Plasma Concentration (Cmax) of RN6G (PF-04382923)	Day 140	691.7 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 12

Secondary

Mean Residence Time (MRT) of RN6G (PF-04382923)

The mean total time drug resides in the body.

Time frame: Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140

Arm	Measure	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Mean Residence Time (MRT) of RN6G (PF-04382923)	818.1 Hour	Standard Deviation 182.15
RN6G 10 mg/kg	Mean Residence Time (MRT) of RN6G (PF-04382923)	1274 Hour	Standard Deviation 352.28
RN6G 15 mg/kg	Mean Residence Time (MRT) of RN6G (PF-04382923)	1121 Hour	Standard Deviation 135.38

Secondary

Minimum Observed Plasma Trough Concentration (Cmin) of RN6G (PF-04382923)

Time frame: Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140

Arm	Measure	Value (GEOMETRIC_MEAN)	Dispersion
RN6G 5 mg/kg	Minimum Observed Plasma Trough Concentration (Cmin) of RN6G (PF-04382923)	38.43 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 40
RN6G 10 mg/kg	Minimum Observed Plasma Trough Concentration (Cmin) of RN6G (PF-04382923)	119.7 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 23
RN6G 15 mg/kg	Minimum Observed Plasma Trough Concentration (Cmin) of RN6G (PF-04382923)	201.5 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 27

Secondary

Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Time frame: Day 1 (1 hour, 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	3048.1 percent change	Standard Deviation 934.03
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	1283.4 percent change	Standard Deviation 428.98
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	5736.6 percent change	Standard Deviation 2367.32
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	6750.1 percent change	Standard Deviation 1605.57
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	1836.7 percent change	Standard Deviation 528.74
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	9035.4 percent change	Standard Deviation 2212.53
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	8153.4 percent change	Standard Deviation 3691.2
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	13778.6 percent change	Standard Deviation 4413.73
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	6632.8 percent change	Standard Deviation 2095.25
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	6536.9 percent change	Standard Deviation 1533.6
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H post-dose Day 1	2129.1 percent change	Standard Deviation 971.74
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	8274.4 percent change	Standard Deviation 2373.14
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	4104.0 percent change	Standard Deviation 781.38
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	7539.0 percent change	Standard Deviation 2097.66
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	4001.5 percent change	Standard Deviation 1313.42
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	10332.3 percent change	Standard Deviation 2454.3
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	7033.1 percent change	Standard Deviation 1783.12
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	9742.8 percent change	Standard Deviation 1628.75
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	838.8 percent change	Standard Deviation 262.62
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	8033.3 percent change	Standard Deviation 2202.15
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	5034.2 percent change	Standard Deviation 1396.44
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	2277.4 percent change	Standard Deviation 870.42
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 304 / ET	1263.2 percent change	Standard Deviation 640.49
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	13326.7 percent change	Standard Deviation 1838.41
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	10287.0 percent change	Standard Deviation 2294.92
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	12858.0 percent change	Standard Deviation 1914.67
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	12713.5 percent change	Standard Deviation 2035.1
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	11719.8 percent change	Standard Deviation 2354.18
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	5332.4 percent change	Standard Deviation 437.02
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	13197.8 percent change	Standard Deviation 1567.68
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	9991.6 percent change	Standard Deviation 4745.47
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	10766.1 percent change	Standard Deviation 2561.52
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	9483.1 percent change	Standard Deviation 2136.77
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	1051.5 percent change	Standard Deviation 230.65
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	8124.3 percent change	Standard Deviation 1400.09
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 154	12461.9 percent change	Standard Deviation 1481.16
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	6169.0 percent change	Standard Deviation 996.4
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	660.9 percent change	Standard Deviation 101.2
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	15838.7 percent change	Standard Deviation 2208.15
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	4501.8 percent change	Standard Deviation 758.64
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	4228.9 percent change	Standard Deviation 1141.96
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	9614.6 percent change	Standard Deviation 1371.1
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	12606.4 percent change	Standard Deviation 1626.29
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	7229.3 percent change	Standard Deviation 1982.4
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H post-dose Day 1	1649.8 percent change	Standard Deviation 190.06
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	12296.0 percent change	Standard Deviation 1777.75
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	9132.2 percent change	Standard Deviation 1770.33
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	752.8 percent change	Standard Deviation 247.2
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	1082.6 percent change	Standard Deviation 225.11
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H post-dose Day 1	1509.3 percent change	Standard Deviation 255.86
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	5328.4 percent change	Standard Deviation 422.35
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	11658.5 percent change	Standard Deviation 2346.26
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	8606.3 percent change	Standard Deviation 2099.47
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	7485.9 percent change	Standard Deviation 2422.75
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	11600.4 percent change	Standard Deviation 1173.09
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	9938.9 percent change	Standard Deviation 2032.57
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	12933.0 percent change	Standard Deviation 1384.7
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	11153.8 percent change	Standard Deviation 978.44
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	14043.1 percent change	Standard Deviation 3217.61
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	13528.7 percent change	Standard Deviation 1209.21
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	17840.0 percent change	Standard Deviation 3578.16
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	16216.1 percent change	Standard Deviation 2105.17
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	16473.9 percent change	Standard Deviation 3063.74
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	17173.8 percent change	Standard Deviation 2625.79
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	17656.9 percent change	Standard Deviation 7083.3
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	19190.4 percent change	Standard Deviation 4117.8
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 154	22722.9 percent change	Standard Deviation 2317.53
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	17703.0 percent change	Standard Deviation 3291.42
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	6880.8 percent change	Standard Deviation 2087.34
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 304 / ET	1603.7 percent change	Standard Deviation 481.43
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H post-dose Day 1	3.2 percent change	Standard Deviation 12.13
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	-11.2 percent change	Standard Deviation 9.09
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	-2.8 percent change	Standard Deviation 23.72
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	1.0 percent change	Standard Deviation 22.07
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	1.8 percent change	Standard Deviation 12.92
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	-9.6 percent change	Standard Deviation 13.47
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	-0.7 percent change	Standard Deviation 8.35
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	6.5 percent change	Standard Deviation 15.76
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 304 / ET	10.9 percent change	Standard Deviation 32.02
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	-7.8 percent change	Standard Deviation 15.61
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	-2.1 percent change	Standard Deviation 5.38
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	14.5 percent change	Standard Deviation 35.7
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 154	-12.7 percent change	Standard Deviation 13.89
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	-1.0 percent change	Standard Deviation 7.54
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	-0.4 percent change	Standard Deviation 10.07
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	4.9 percent change	Standard Deviation 23.25
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	0.4 percent change	Standard Deviation 9.79
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	16.6 percent change	Standard Deviation 51.02
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	-6.4 percent change	Standard Deviation 15.2
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	-4.5 percent change	Standard Deviation 16.16
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	-5.3 percent change	Standard Deviation 22.33
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	-1.5 percent change	Standard Deviation 18.15
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	-3.5 percent change	Standard Deviation 28.74
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	-12.5 percent change	Standard Deviation 9.43

Secondary

Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Time frame: Day 1 (1 hour, 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	43.0 percent change	Standard Deviation 20.81
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	257.8 percent change	Standard Deviation 101.75
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	83.2 percent change	Standard Deviation 46.16
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	111.1 percent change	Standard Deviation 25.89
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	15.9 percent change	Standard Deviation 14.37
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	337.7 percent change	Standard Deviation 67.82
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	129.8 percent change	Standard Deviation 71.07
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	360.6 percent change	Standard Deviation 70.15
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	92.5 percent change	Standard Deviation 17.6
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	278.1 percent change	Standard Deviation 163.6
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H post-dose Day 1	306.4 percent change	Standard Deviation 111.88
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	264.4 percent change	Standard Deviation 55.03
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	55.8 percent change	Standard Deviation 34.06
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	119.7 percent change	Standard Deviation 30.44
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	59.7 percent change	Standard Deviation 38.36
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	397.0 percent change	Standard Deviation 70.71
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	87.8 percent change	Standard Deviation 38.89
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	168.4 percent change	Standard Deviation 41.44
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	199.0 percent change	Standard Deviation 74.28
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	128.9 percent change	Standard Deviation 42.92
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	77.0 percent change	Standard Deviation 16.8
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	29.7 percent change	Standard Deviation 37.85
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 304 / ET	15.4 percent change	Standard Deviation 66.96
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	394.6 percent change	Standard Deviation 196.64
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	146.3 percent change	Standard Deviation 146.97
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	207.3 percent change	Standard Deviation 159.23
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	345.7 percent change	Standard Deviation 201.63
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	207.4 percent change	Standard Deviation 176.39
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	461.6 percent change	Standard Deviation 175.95
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	249.0 percent change	Standard Deviation 204.05
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	185.8 percent change	Standard Deviation 164.1
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	176.4 percent change	Standard Deviation 159.42
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	164.3 percent change	Standard Deviation 114.69
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	254.3 percent change	Standard Deviation 104.05
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	121.1 percent change	Standard Deviation 132.7
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 154	241.5 percent change	Standard Deviation 196.56
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	87.2 percent change	Standard Deviation 92.62
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	163.7 percent change	Standard Deviation 102.35
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	539.2 percent change	Standard Deviation 291.07
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	36.5 percent change	Standard Deviation 57.79
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	27.1 percent change	Standard Deviation 74.59
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	118.9 percent change	Standard Deviation 116.56
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	459.8 percent change	Standard Deviation 234.24
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	102.2 percent change	Standard Deviation 74.51
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H post-dose Day 1	341.8 percent change	Standard Deviation 174.55
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	172.1 percent change	Standard Deviation 141.94
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	163.7 percent change	Standard Deviation 37.92
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	340.2 percent change	Standard Deviation 133.1
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	412.7 percent change	Standard Deviation 98.9
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H post-dose Day 1	545.8 percent change	Standard Deviation 131.45
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	708.5 percent change	Standard Deviation 200.76
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	306.5 percent change	Standard Deviation 45.29
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	153.3 percent change	Standard Deviation 25.6
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	157.6 percent change	Standard Deviation 103.15
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	267.5 percent change	Standard Deviation 59.75
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	220.4 percent change	Standard Deviation 62.44
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	314.3 percent change	Standard Deviation 75.17
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	224.2 percent change	Standard Deviation 40.97
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	315.3 percent change	Standard Deviation 127.45
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	275.2 percent change	Standard Deviation 92.55
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	393.6 percent change	Standard Deviation 66.08
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	297.3 percent change	Standard Deviation 48.94
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	553.7 percent change	Standard Deviation 122.06
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	637.8 percent change	Standard Deviation 146.28
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	781.5 percent change	Standard Deviation 165.36
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	889.4 percent change	Standard Deviation 267.61
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 154	506.2 percent change	Standard Deviation 142.03
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	366.6 percent change	Standard Deviation 91.33
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	102.6 percent change	Standard Deviation 41.52
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 304 / ET	11.0 percent change	Standard Deviation 12.78
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H post-dose Day 1	10.4 percent change	Standard Deviation 12.86
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	-28.8 percent change	Standard Deviation 33.79
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	-10.7 percent change	Standard Deviation 36.98
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	-7.7 percent change	Standard Deviation 30.53
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	0.5 percent change	Standard Deviation 23.12
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	-4.9 percent change	Standard Deviation 53.65
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	-2.6 percent change	Standard Deviation 18.74
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	20.9 percent change	Standard Deviation 49.01
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 304 / ET	-38.8 percent change	Standard Deviation 22.12
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	-31.3 percent change	Standard Deviation 20.95
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	21.2 percent change	Standard Deviation 47.33
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	8.2 percent change	Standard Deviation 68.87
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 154	-32.3 percent change	Standard Deviation 22.75
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	19.6 percent change	Standard Deviation 58.46
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	-9.8 percent change	Standard Deviation 31.29
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	-21.1 percent change	Standard Deviation 25.48
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	-7.0 percent change	Standard Deviation 20.63
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	0.2 percent change	Standard Deviation 68.99
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	-20.2 percent change	Standard Deviation 21.83
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	-16.7 percent change	Standard Deviation 29.36
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	-22.8 percent change	Standard Deviation 27.34
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	-24.0 percent change	Standard Deviation 24.14
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	-12.4 percent change	Standard Deviation 34.64
Placebo	Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	-23.6 percent change	Standard Deviation 27.01

Secondary

Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Time frame: Day 1 (1 hour , 2 hours, 4 hours post dose), 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140 (predose, 1 hour, 2 hours, 4 hours post dose), 141, 154, 168, 224, 304/ET

Arm	Measure	Group	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	6096.9 Percent change	Standard Deviation 2660.58
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	1835.9 Percent change	Standard Deviation 859.97
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	12401.6 Percent change	Standard Deviation 5938.63
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	16323.4 Percent change	Standard Deviation 6890.74
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	3168.7 Percent change	Standard Deviation 1297.49
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	17418.4 Percent change	Standard Deviation 7204.24
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	17643.7 Percent change	Standard Deviation 7989.43
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	27212.1 Percent change	Standard Deviation 12018.62
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	14458.4 Percent change	Standard Deviation 7747.84
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	11999.3 Percent change	Standard Deviation 5344.01
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percentage change at 4 H post-dose Day 1	2899.5 Percent change	Standard Deviation 1575.11
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	15067.2 Percent change	Standard Deviation 6922.6
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	8156.5 Percent change	Standard Deviation 3005.78
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	19415.4 Percent change	Standard Deviation 9203.47
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	8930.3 Percent change	Standard Deviation 3978.36
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	18171.1 Percent change	Standard Deviation 7481.91
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	14815.6 Percent change	Standard Deviation 6477.51
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	20902.9 Percent change	Standard Deviation 8509.92
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	1194.4 Percent change	Standard Deviation 541.02
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	17482.8 Percent change	Standard Deviation 6740.53
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	10497.3 Percent change	Standard Deviation 4494.06
RN6G 5 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	7954.0 Percent change	Standard Deviation 5003.96
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 304 / ET	3182.9 Percent change	Standard Deviation 2499.39
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	27192.5 Percent change	Standard Deviation 19768.55
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	21128.7 Percent change	Standard Deviation 14305.48
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	28726.4 Percent change	Standard Deviation 20620.23
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	25462.2 Percent change	Standard Deviation 18562.61
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	26653.1 Percent change	Standard Deviation 19128.49
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	9771.3 Percent change	Standard Deviation 6115.66
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	31839.9 Percent change	Standard Deviation 22850.11
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	26584.4 Percent change	Standard Deviation 19667.93
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	26639.1 Percent change	Standard Deviation 19545.03
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	22214.1 Percent change	Standard Deviation 16132.62
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	1682.9 Percent change	Standard Deviation 1332.55
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	16692.0 Percent change	Standard Deviation 11490.17
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 154	37731.7 Percent change	Standard Deviation 28276.18
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	13136.7 Percent change	Standard Deviation 9098.67
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	1032.9 Percent change	Standard Deviation 860.01
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	36042.0 Percent change	Standard Deviation 25934.3
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	8714.5 Percent change	Standard Deviation 5831.88
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	9003.9 Percent change	Standard Deviation 7319.06
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	25626.3 Percent change	Standard Deviation 16350.32
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	26342.6 Percent change	Standard Deviation 19070.4
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	16396.4 Percent change	Standard Deviation 11269.8
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percentage change at 4 H post-dose Day 1	2044.5 Percent change	Standard Deviation 1595.93
RN6G 10 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	29483.6 Percent change	Standard Deviation 20874.07
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	40069.0 Percent change	Standard Deviation 6897.78
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	1973.6 Percent change	Standard Deviation 911.19
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	2805.4 Percent change	Standard Deviation 1272.35
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percentage change at 4 H post-dose Day 1	3937.1 Percent change	Standard Deviation 1079.28
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	18931.0 Percent change	Standard Deviation 534.93
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	47008.5 Percent change	Standard Deviation 3530.28
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	35595.3 Percent change	Standard Deviation 3776.71
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	28850.5 Percent change	Standard Deviation 7352.55
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	55139.0 Percent change	Standard Deviation 10148.46
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	49171.9 Percent change	Standard Deviation 10668.22
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	74636.0 Percent change	Standard Deviation 11949.05
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	60045.8 Percent change	Standard Deviation 2947.55
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	78724.0 Percent change	Standard Deviation 16617.7
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	70458.8 Percent change	Standard Deviation 8749.39
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	84383.9 Percent change	Standard Deviation 3636.46
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	77175.0 Percent change	Standard Deviation 4729.87
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	70123.0 Percent change	Standard Deviation 7885.1
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	68054.8 Percent change	Standard Deviation 6441.82
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	76896.5 Percent change	Standard Deviation 7656.04
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	80464.2 Percent change	Standard Deviation 11546.49
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 154	95456.8 Percent change	Standard Deviation 14665.51
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	80845.7 Percent change	Standard Deviation 10646.37
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	28846.0 Percent change	Standard Deviation 8155.08
RN6G 15 mg/kg	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 304 / ET	6063.6 Percent change	Standard Deviation 1598.08
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percentage change at 4 H post-dose Day 1	14.5 Percent change	Standard Deviation 61.22
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H Post dose Day 140	-25.9 Percent change	Standard Deviation 21.26
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 56	20.9 Percent change	Standard Deviation 120.63
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 45	19.0 Percent change	Standard Deviation 84.63
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 2 H post-dose Day 1	17.7 Percent change	Standard Deviation 37.96
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 4 H Post dose Day 140	-29.4 Percent change	Standard Deviation 24.61
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 28	-3.3 Percent change	Standard Deviation 72.57
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 19	-13.2 Percent change	Standard Deviation 18.08
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 304 / ET	-31.6 Percent change	Standard Deviation 27.03
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 141	-11.0 Percent change	Standard Deviation 30.66
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 14	-12.4 Percent change	Standard Deviation 20.1
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 224	-22.2 Percent change	Standard Deviation 27.76
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 154	-21.2 Percent change	Standard Deviation 14.56
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 7	3.1 Percent change	Standard Deviation 13.89
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 2	4.3 Percent change	Standard Deviation 29.32
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 131	-6.5 Percent change	Standard Deviation 28.29
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H post-dose Day 1	3.8 Percent change	Standard Deviation 21.25
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Pre-dose Day 140	6.8 Percent change	Standard Deviation 25.29
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 112	75.8 Percent change	Standard Deviation 138.85
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 103	48.2 Percent change	Standard Deviation 120.26
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 168	-10.1 Percent change	Standard Deviation 29.15
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at 1 H Post dose Day 140	-2.3 Percent change	Standard Deviation 23.04
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 84	51.2 Percent change	Standard Deviation 124.25
Placebo	Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET	Percent change at Day 75	72.3 Percent change	Standard Deviation 122.02

Secondary

Plasma Concentration (Css) at Steady State of RN6G (PF-04382923)

Css is the concentration of the drug at the state when the amount of drug administered is equal to the amount of drug eliminated.

Time frame: Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140

Arm	Measure	Value (GEOMETRIC_MEAN)	Dispersion
RN6G 5 mg/kg	Plasma Concentration (Css) at Steady State of RN6G (PF-04382923)	74.75 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 20
RN6G 10 mg/kg	Plasma Concentration (Css) at Steady State of RN6G (PF-04382923)	208.7 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 14
RN6G 15 mg/kg	Plasma Concentration (Css) at Steady State of RN6G (PF-04382923)	317.2 Microgram per milliliter (mcg/mL)	Geometric Coefficient of Variation 16

Secondary

Plasma Decay Half-Life (t1/2) of RN6G (PF-04382923)

Plasma decay half-life is the time measured for the plasma concentration to decrease by one half.

Time frame: Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140

Arm	Measure	Value (MEAN)	Dispersion
RN6G 5 mg/kg	Plasma Decay Half-Life (t1/2) of RN6G (PF-04382923)	25.14 Hour	Standard Deviation 5.0774
RN6G 10 mg/kg	Plasma Decay Half-Life (t1/2) of RN6G (PF-04382923)	42.00 Hour	Standard Deviation 6.6321
RN6G 15 mg/kg	Plasma Decay Half-Life (t1/2) of RN6G (PF-04382923)	38.10 Hour	Standard Deviation 4.9738

Secondary

Systemic Clearance (CL) of RN6G (PF-04382923)

CL is a quantitative measure of the rate at which a drug substance is removed from the body.

Time frame: Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140

Arm	Measure	Value (GEOMETRIC_MEAN)	Dispersion
RN6G 5 mg/kg	Systemic Clearance (CL) of RN6G (PF-04382923)	0.09954 Milliliter per hour per kilogram	Geometric Coefficient of Variation 20
RN6G 10 mg/kg	Systemic Clearance (CL) of RN6G (PF-04382923)	0.07129 Milliliter per hour per kilogram	Geometric Coefficient of Variation 14
RN6G 15 mg/kg	Systemic Clearance (CL) of RN6G (PF-04382923)	0.07036 Milliliter per hour per kilogram	Geometric Coefficient of Variation 16

Secondary

Time to Reach Maximum Observed Plasma Concentration (Tmax) of RN6G (PF-04382923)

Time frame: Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 168, 336 hours on Day 1 and 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140

Arm	Measure	Group	Value (MEDIAN)
RN6G 5 mg/kg	Time to Reach Maximum Observed Plasma Concentration (Tmax) of RN6G (PF-04382923)	Day 140	1.77 Hour
RN6G 5 mg/kg	Time to Reach Maximum Observed Plasma Concentration (Tmax) of RN6G (PF-04382923)	Day 1	1.49 Hour
RN6G 10 mg/kg	Time to Reach Maximum Observed Plasma Concentration (Tmax) of RN6G (PF-04382923)	Day 1	2.06 Hour
RN6G 10 mg/kg	Time to Reach Maximum Observed Plasma Concentration (Tmax) of RN6G (PF-04382923)	Day 140	2.05 Hour
RN6G 15 mg/kg	Time to Reach Maximum Observed Plasma Concentration (Tmax) of RN6G (PF-04382923)	Day 1	2.17 Hour
RN6G 15 mg/kg	Time to Reach Maximum Observed Plasma Concentration (Tmax) of RN6G (PF-04382923)	Day 140	1.32 Hour

Secondary

Volume of Distribution at Steady State (Vss) of RN6G (PF-04382923)

Volume of distribution is defined as the theoretical volume in which the total amount of drug would need to be uniformly distributed to produce the desired blood concentration of a drug. Steady state volume of distribution (Vss) is the apparent volume of distribution at steady-state.

Time frame: Pre-dose: 0 hour on Day 1, 28, 56, 84,112,140; Post-dose: 1, 2, 4, 24, 336, 672, 1992, 3936 hours on Day 140

Arm	Measure	Value (GEOMETRIC_MEAN)	Dispersion
RN6G 5 mg/kg	Volume of Distribution at Steady State (Vss) of RN6G (PF-04382923)	79.52 Milliliter per kilogram (mL/kg)	Geometric Coefficient of Variation 23
RN6G 10 mg/kg	Volume of Distribution at Steady State (Vss) of RN6G (PF-04382923)	88.04 Milliliter per kilogram (mL/kg)	Geometric Coefficient of Variation 26
RN6G 15 mg/kg	Volume of Distribution at Steady State (Vss) of RN6G (PF-04382923)	78.45 Milliliter per kilogram (mL/kg)	Geometric Coefficient of Variation 11

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026

Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy

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Study design

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Secondary

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Participant flow

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Withdrawals & dropouts

Baseline characteristics

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Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug

Number of Participants With Ocular Treatment Emergent Adverse Events (TEAEs) Categorized by Severity

Number of Participants With Positive Anti-Drug-Antibodies (ADA) and Neutralizing Antibodies (Nab)

Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Causal Relationship to Study Drug

Number of Participants With Systemic Treatment Emergent Adverse Events (TEAEs) Categorized by Severity

Number of Participants With Toxicity or Intolerable Dose Criteria

Number of Participants With Treatment Emergent Adverse Events (TEAEs): All Causalities and TEAEs Categorized by Causal Relationship to Study Drug

Number of Participants With Treatment Emergent Adverse Events (TEAEs) Categorized by Severity

Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of RN6G (PF-04382923)

Change From Baseline Electrocardiogram (ECG) 12-lead at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Bilirubin, Direct Bilirubin, Blood Urea Nitrogen, Creatinine, Uric Acid, Calcium, Phosphate, Glucose, Cholesterol, Triglycerides, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Heart Rate at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Laboratory Assessments: Aspartate Aminotransferase, Creatine Kinase, Alanine Aminotransferase, Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase, Alkaline Phosphatase at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Laboratory Assessments: Beta Interleukin-1, Interleukin-6, Alpha Tumor Necrosis Factor, Interferon (Gamma) at Day 28, 56, 84, 112, 140

Change From Baseline in Laboratory Assessments: Cluster of Differentiation 4 (C4D) at Day 28, 56, 84, 112, 140

Change From Baseline in Laboratory Assessments: Component of Complement (C3A, C5B-9) at Day 28, 56, 84, 112, 140

Change From Baseline in Laboratory Assessments: Hematocrit at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Laboratory Assessments: Platelets, White Blood Cells (WBCs), Neutrophils (Absolute), Eosinophils (Absolute), Basophils (Absolute), Lymphocytes (Absolute), Monocytes (Absolute) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Laboratory Assessments: Protein, Albumin, Hemoglobin at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Laboratory Assessments: Prothrombin Time (PT), Partial Thromboplastin Time at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Laboratory Assessments: Red Blood Cells (RBCs) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Laboratory Assessments: Sodium, Potassium, Chloride, Bicarbonate, Magnesium at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Laboratory Assessments: Urine pH at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Laboratory Assessments: Urine Specific Gravity at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Change From Baseline in Prothrombin Time (PT) International Normalized Ratio (INR) at Day 28, 56, 84, 112, 140, 168, 224, 304/ET

Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Pulse Rate

Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Systolic and Diastolic Blood Pressure

Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Temperature

Change From Baseline in Vital Signs at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET: Weight

Change From Electrocardiogram (ECG): QTcF Interval (Fridericia's Correction) at Day 1, 28, 56, 84, 112, 140, 168, 224, 304/ET

Maximum Observed Plasma Concentration (Cmax) of RN6G (PF-04382923)

Mean Residence Time (MRT) of RN6G (PF-04382923)

Minimum Observed Plasma Trough Concentration (Cmin) of RN6G (PF-04382923)

Percent Change From Baseline in Plasma Amyloid (A) Beta (1-40) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Percent Change From Baseline in Plasma Amyloid (A) Beta (1-42) Concentrations at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Percent Change From Baseline in Plasma Total Amyloid (A) Beta (1-X) Concentration at Day 1, 2, 7, 14, 19, 28, 45, 56, 75, 84, 103, 112, 131, 140, 141, 154, 168, 224, 304/ET

Plasma Concentration (Css) at Steady State of RN6G (PF-04382923)

Plasma Decay Half-Life (t1/2) of RN6G (PF-04382923)

Systemic Clearance (CL) of RN6G (PF-04382923)

Time to Reach Maximum Observed Plasma Concentration (Tmax) of RN6G (PF-04382923)

Volume of Distribution at Steady State (Vss) of RN6G (PF-04382923)