Degenerative Meniscal Tear
Conditions
Keywords
Degenerative meniscal tear, Arthroscopy, Exercise therapy
Brief summary
This study is conducted as a collaboration between NAR, Orthopedic Department, Oslo University Hospital,Ullevaal, Hjelp24Nimi Oslo, Martina Hansens Hospital Norway, and University of Southern Denmark, Odense, Denmark. The investigators hypothesize that exercise is more effective than arthroscopic partial meniscectomy: a) on self-reported outcomes, functional performance and muscle strength in middle-aged patients subsequent to arthroscopic partial meniscectomy for a degenerative meniscus tear, and b) in preventing further development of knee osteoarthritis (OA).
Detailed description
The aims of the study are: 1. At 3 months, to investigate the effect of arthroscopic partial meniscectomy versus exercise therapy on muscle strength and knee function in middle-aged patients with degenerative meniscus lesions. 2. At 2 years, to investigate the effect of arthroscopic partial meniscectomy versus exercise therapy on self-reported outcomes in middle aged patients with degenerative meniscus lesions. 3. At 5 years, to describe radiographic changes in knee osteoarthritis development after arthroscopic partial meniscectomy or exercise therapy in middle-aged patients with degenerative meniscus lesions. 4. 4\. At 10 years, to describe radiographic changes in knee osteoarthritis development after arthroscopic partial meniscectomy or exercise therapy in middle-aged patients with degenerative meniscus lesions. Patients included in the study will be randomized into one of two groups. The interventions are: arthroscopic partial meniscectomy and supervised neuromuscular- and strength training. Subjects will be tested before and after intervention, at 12 months, 24 months, five and 10 years. Long-term follow-up studies are particularly important for this patient population. Both meniscal tears and partial meniscectomy has been demonstrated as risk factors for incident knee osteoarthritis and progression. However, it is not known whether the increased risk is due to the meniscal tear per se or resection of the meniscus. Furthermore, patients presenting with symptomatic degenerative meniscal tears have reduced knee muscle strength, which may be an additional risk factor for knee osteoarthritis. While knee muscle weakness has been shown to persist following surgery, the knowledge of long-term changes following surgical and non-surgical interventions for degenerative meniscal tears is limited. Accordingly, long-term between-group differences in muscle strength changes (at 5 and 10 years) and radiographic knee osteoarthritis changes (10 years) will also be investigated
Interventions
PROCEDUREArthroscopic partial menisectomy
Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital.
OTHERSupervised neuromuscular and strength training
Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum
Sponsors
University of Southern Denmark
South-Eastern Norway Regional Health Authority
Oslo University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
35 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age 35-60 years * Knee pain for more than 2 months without a significant trauma * Medial meniscal tear on MRI * Eligible for arthroscopic partial meniscectomy * Grade 0-2 radiographic severity (specification after Kellgren Lawrence)
Exclusion criteria
* Those requiring acute trauma surgeries, including those treated as acute cases in the ER * Ligament injuries * Tumours (MRI) * Pain or other musculoskeletal comorbidities severely affecting lower extremity muscle function overriding the symptoms from the knee * Grade 3 or 4 radiographic severity (specification after Kellgren Lawrence) * Comorbidities excluding physical activities and exercise. * Previous knee surgery within two years * Not able to speak or read Norwegian, drug abuse or mental problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| KOOS4 - Change From Baseline | 24 months | The Knee Injury and Osteoarthritis Outcome Score (KOOS) is a patient administered questionnaire containing 42 questions in 5 subscales concerning patient´s knee related pain, other knee symptoms, activity of daily life, sport and recreation and quality of life.Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale. KOOS4 is a composite score of the mean values of four of the five KOOS subscales (KOOS Pain, KOOS Symptoms, KOOS Sport/Rec and KOOS QOL). |
| Peak Torque Knee Extension - Change From Baseline | at 3 months | Peak torque knee extension (Newton meter) - Change from baseline |
| Peak Torque Knee Flexion - Change From Baseline | 3 months | Peak torque knee flexion (Newton meter) - Change from baseline |
| Knee Osteoarthritis Incidence | 5 years | In line with baseline assessment of the tibiofemoral joint, standing radiographs of the tibiofemoral joint is taken bilaterally with a Synaflexer Frame (Synarc Inc) that ensure alignment of the x-ray beam and standardize the placement of the knee in approximately 20 degrees of flexion and 5 degrees of external rotation for an anterior-posterior view. A sagittal view is also taken with the knee in flexion. Kellgren and Lawrence will be used for classification in addition to description of osteophytes and joint Space narrowing (JSN) will be measured. |
| Radiographic Progression (the Osteoarthritis Research Society International [OARSI] Atlas) [Time Frame: At 10 Years] | 10 years | Radiographic progression based on the sum of marginal tibiofemoral osteophyte grades and tibiofemoral joint space narrowing (the Osteoarthritis Research Society International \[OARSI\] atlas) \[Time Frame: At 10 years\] |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| One-leg Hop Test - Change in From Baseline | 12 months | Change in distance (meters) hopped on the One leg hop test from baseline to 12 months (higher is better). |
| KOOS Pain - Change From Baseline | 24 months | Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale. |
| KOOS Symptoms - Change From Baseline | 24 months | Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptoms subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale. |
| KOOS ADL - Change From Baseline | 24 months | Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Activities in Daily Living (ADL) subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale |
| KOOS Sport/Rec - Change From Baseline | 24 months | Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Sport and recreation (Sport/Rec) subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale. |
| KOOS QOL - Change From Baseline | 24 months | Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life (QOL) subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale. |
| SF-36 MCS - Change From Baseline | 24 months | Change in Short form 36 mental component summary (SF-36 MCS) from baseline to 24 months (range: 0-100; higher is better) |
| 6 Meter Timed Hop Test - Change From Baseline | 3 months | Change in time (seconds) on the 6 meter timed hop test from baseline to 3 months (lower is better) |
| KOOS Pain Subscale - Change From Baseline | 5 years | Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain subscale from baseline to five years (range: 0-100; higher is better). |
| KOOS Symptoms Subscale - Change From Baseline | 5 years | Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptoms subscale from baseline to five years (range: 0-100; higher is better). |
| KOOS ADL Subscale - Change From Baseline | 5 years | Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Activities of Daily Living (ADL) subscale from baseline to five years (range: 0-100; higher is better). |
| KOOS Sport/Rec Subscale - Change From Baseline | 5 years | Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Sport and Recreation (Sport/Rec) subscale from baseline to five years (range: 0-100; higher is better). |
| KOOS QOL Subscale - Change From Baseline | 5 years | Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life (QOL) subscale from baseline to five years (range: 0-100; higher is better). |
| Knee Osteoarthritis Incidence (Kellgren and Lawrence Classification ) | 10 years | Knee osteoarthritis incidence (Kellgren and Lawrence classification) \[ Time Frame: 10 years\] |
| KOOS4 - Change From Baseline | 10 years | Change in KOOS4 from baseline to 10 years (range: 0-100; higher is better). KOOS4 is a composite score of the mean values of four of the five Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales (KOOS Pain, KOOS Symptoms, KOOS Sport/Rec and KOOS QOL). |
| SF-36 PCS - Change From Baseline | 24 months | Change in Short form 36 physical component summary (SF-36 PCS) from baseline to 24 months (range: 0-100; higher is better) |
| One Leg Hop Test - Change From Baseline | 3 months | Change in distance (meters) hopped on the One leg hop test from baseline to three months (higher is better). |
| Knee Bends 30 Sec - Change From Baseline | 3 months | Change in number of repetitions performed on the Knee bends 30 seconds test from baseline to 3 months (higher is better). |
| Peak Torque Knee Extension - Change From Baseline | 1 year | Change in Peak torque knee extension (Newton meter) from baseline to 12 months (higher is better). |
| Peak Torque Knee Flexion - Change From Baseline | 12 months | Change in Peak torque knee flexion (Newton meter) from baseline to 12 months (higher is better). |
Countries
Norway
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Arthroscopic Partial Meniscectomy Standard arthroscopic partial meniscectomy - NGD 1
Arthroscopic partial menisectomy: Standard arthroscopic partial meniscectomy, NGD 1. Carried out at Ullevaal University Hospital and Martina Hansens Hospital. | 70 |
| Exercise Therapy Supervised neuromuscular- and strength training
Supervised neuromuscular and strength training: Supervised exercise therapy in 12 weeks, both neuromuscular- and strength training. Carried out at Nimi Ullevaal Oslo or Gnist trending- og fysioterapi, Baerum | 70 |
| Total | 140 |
Baseline characteristics
| Characteristic | Exercise Therapy | Arthroscopic Partial Meniscectomy | Total |
|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical Between 18 and 65 years | 70 Participants | 70 Participants | 140 Participants |
| Age, Continuous | 50.2 years | 48.9 years | 49.6 years |
| Region of Enrollment Norway | 70 participants | 70 participants | 140 participants |
| Sex: Female, Male Female | 27 Participants | 27 Participants | 54 Participants |
| Sex: Female, Male Male | 43 Participants | 43 Participants | 86 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 70 | 0 / 70 |
| other Total, other adverse events | 0 / 70 | 0 / 70 |
| serious Total, serious adverse events | 0 / 70 | 0 / 70 |
Outcome results
Primary
Knee Osteoarthritis Incidence
In line with baseline assessment of the tibiofemoral joint, standing radiographs of the tibiofemoral joint is taken bilaterally with a Synaflexer Frame (Synarc Inc) that ensure alignment of the x-ray beam and standardize the placement of the knee in approximately 20 degrees of flexion and 5 degrees of external rotation for an anterior-posterior view. A sagittal view is also taken with the knee in flexion. Kellgren and Lawrence will be used for classification in addition to description of osteophytes and joint Space narrowing (JSN) will be measured.
Time frame: 5 years
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | Knee Osteoarthritis Incidence | 10 Participants |
| Exercise Therapy | Knee Osteoarthritis Incidence | 9 Participants |
Primary
KOOS4 - Change From Baseline
The Knee Injury and Osteoarthritis Outcome Score (KOOS) is a patient administered questionnaire containing 42 questions in 5 subscales concerning patient´s knee related pain, other knee symptoms, activity of daily life, sport and recreation and quality of life.Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale. KOOS4 is a composite score of the mean values of four of the five KOOS subscales (KOOS Pain, KOOS Symptoms, KOOS Sport/Rec and KOOS QOL).
Time frame: 24 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS4 - Change From Baseline | 24.4 units on a scale |
| Exercise Therapy | KOOS4 - Change From Baseline | 25.3 units on a scale |
Comparison: Power calculation: The sample size calculation was based on the change in KOOS4 from baseline to two year follow-up. To detect a 10 point difference with a standard deviation of 15, with a level of power of 90%, level of significance of 0.05, and an estimated 15% dropout rate at two years, we determined that we would need 56 participants in each group. To allow for a 20% crossover rate, we randomised 140 participants.p-value: <0.05Mixed Models Analysis
Primary
Peak Torque Knee Extension - Change From Baseline
Peak torque knee extension (Newton meter) - Change from baseline
Time frame: at 3 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | Peak Torque Knee Extension - Change From Baseline | -2.63 Newton meter |
| Exercise Therapy | Peak Torque Knee Extension - Change From Baseline | 20.7 Newton meter |
Primary
Peak Torque Knee Flexion - Change From Baseline
Peak torque knee flexion (Newton meter) - Change from baseline
Time frame: 3 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | Peak Torque Knee Flexion - Change From Baseline | 5.0 Newton meter |
| Exercise Therapy | Peak Torque Knee Flexion - Change From Baseline | 12.8 Newton meter |
Primary
Radiographic Progression (the Osteoarthritis Research Society International [OARSI] Atlas) [Time Frame: At 10 Years]
Radiographic progression based on the sum of marginal tibiofemoral osteophyte grades and tibiofemoral joint space narrowing (the Osteoarthritis Research Society International \[OARSI\] atlas) \[Time Frame: At 10 years\]
Time frame: 10 years
Secondary
6 Meter Timed Hop Test - Change From Baseline
Change in time (seconds) on the 6 meter timed hop test from baseline to 3 months (lower is better)
Time frame: 3 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | 6 Meter Timed Hop Test - Change From Baseline | -0.1 Seconds |
| Exercise Therapy | 6 Meter Timed Hop Test - Change From Baseline | -0.5 Seconds |
Secondary
6 Meter Timed Hop Test - Change From Baseline
Change in time (seconds) on the 6 meter timed hop test from baseline to 12 months (lower is better).
Time frame: 12 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | 6 Meter Timed Hop Test - Change From Baseline | -0.3 Seconds |
| Exercise Therapy | 6 Meter Timed Hop Test - Change From Baseline | -0.6 Seconds |
Secondary
Knee Bends 30 Sec - Change From Baseline
Change in number of repetitions performed on the Knee bends 30 seconds test from baseline to 12 months (higher is better).
Time frame: 12 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | Knee Bends 30 Sec - Change From Baseline | 10.6 Number of repetitions |
| Exercise Therapy | Knee Bends 30 Sec - Change From Baseline | 9.2 Number of repetitions |
Secondary
Knee Bends 30 Sec - Change From Baseline
Change in number of repetitions performed on the Knee bends 30 seconds test from baseline to 3 months (higher is better).
Time frame: 3 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | Knee Bends 30 Sec - Change From Baseline | 8.5 Number of repetitions |
| Exercise Therapy | Knee Bends 30 Sec - Change From Baseline | 9.9 Number of repetitions |
Secondary
Knee Osteoarthritis Incidence (Kellgren and Lawrence Classification )
Knee osteoarthritis incidence (Kellgren and Lawrence classification) \[ Time Frame: 10 years\]
Time frame: 10 years
Secondary
KOOS4 - Change From Baseline
Change in KOOS4 from baseline to 10 years (range: 0-100; higher is better). KOOS4 is a composite score of the mean values of four of the five Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales (KOOS Pain, KOOS Symptoms, KOOS Sport/Rec and KOOS QOL).
Time frame: 10 years
Secondary
KOOS ADL - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Activities in Daily Living (ADL) subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale
Time frame: 24 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS ADL - Change From Baseline | 13.8 units on a scale |
| Exercise Therapy | KOOS ADL - Change From Baseline | 15.4 units on a scale |
Secondary
KOOS ADL Subscale - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Activities of Daily Living (ADL) subscale from baseline to 10 years (range: 0-100; higher is better).
Time frame: 10 years
Secondary
KOOS ADL Subscale - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Activities of Daily Living (ADL) subscale from baseline to five years (range: 0-100; higher is better).
Time frame: 5 years
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS ADL Subscale - Change From Baseline | 14.5 units on a scale |
| Exercise Therapy | KOOS ADL Subscale - Change From Baseline | 14.6 units on a scale |
Secondary
KOOS Pain - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale.
Time frame: 24 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS Pain - Change From Baseline | 21.7 units on a scale |
| Exercise Therapy | KOOS Pain - Change From Baseline | 23.2 units on a scale |
Secondary
KOOS Pain Subscale - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain subscale from baseline to 10 years (range: 0-100; higher is better).
Time frame: 10 years
Secondary
KOOS Pain Subscale - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain subscale from baseline to five years (range: 0-100; higher is better).
Time frame: 5 years
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS Pain Subscale - Change From Baseline | 23.8 units on a scale |
| Exercise Therapy | KOOS Pain Subscale - Change From Baseline | 21.3 units on a scale |
Secondary
KOOS QOL - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life (QOL) subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale.
Time frame: 24 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS QOL - Change From Baseline | 33.1 units on a scale |
| Exercise Therapy | KOOS QOL - Change From Baseline | 31.3 units on a scale |
Secondary
KOOS QOL Subscale - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life (QOL) subscale from baseline to ten years (range: 0-100; higher is better).
Time frame: 10 years
Secondary
KOOS QOL Subscale - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life (QOL) subscale from baseline to five years (range: 0-100; higher is better).
Time frame: 5 years
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS QOL Subscale - Change From Baseline | 34.4 units on a scale |
| Exercise Therapy | KOOS QOL Subscale - Change From Baseline | 30.7 units on a scale |
Secondary
KOOS Sport/Rec - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Sport and recreation (Sport/Rec) subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale.
Time frame: 24 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS Sport/Rec - Change From Baseline | 30.8 units on a scale |
| Exercise Therapy | KOOS Sport/Rec - Change From Baseline | 29.3 units on a scale |
Secondary
KOOS Sport/Rec Subscale - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Sport and Recreation (Sport/Rec) subscale from baseline to five years (range: 0-100; higher is better).
Time frame: 5 years
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS Sport/Rec Subscale - Change From Baseline | 33.4 units on a scale |
| Exercise Therapy | KOOS Sport/Rec Subscale - Change From Baseline | 29.0 units on a scale |
Secondary
KOOS Sport/Rec Subscale - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Sport and recreation (Sport/Rec) subscale from baseline to five years (range: 0-100; higher is better).
Time frame: 10 years
Secondary
KOOS Symptoms - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptoms subscale from baseline to two years. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale.
Time frame: 24 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS Symptoms - Change From Baseline | 12.0 units on a scale |
| Exercise Therapy | KOOS Symptoms - Change From Baseline | 17.4 units on a scale |
Secondary
KOOS Symptoms Subscale - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptoms subscale from baseline to 10 years (range: 0-100; higher is better).
Time frame: 10 years
Secondary
KOOS Symptoms Subscale - Change From Baseline
Change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptoms subscale from baseline to five years (range: 0-100; higher is better).
Time frame: 5 years
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | KOOS Symptoms Subscale - Change From Baseline | 12.9 units on a scale |
| Exercise Therapy | KOOS Symptoms Subscale - Change From Baseline | 13.2 units on a scale |
Secondary
One Leg Hop Test - Change From Baseline
Change in distance (meters) hopped on the One leg hop test from baseline to three months (higher is better).
Time frame: 3 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | One Leg Hop Test - Change From Baseline | 6.1 Meters |
| Exercise Therapy | One Leg Hop Test - Change From Baseline | 11.0 Meters |
Secondary
One-leg Hop Test - Change in From Baseline
Change in distance (meters) hopped on the One leg hop test from baseline to 12 months (higher is better).
Time frame: 12 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | One-leg Hop Test - Change in From Baseline | 13.1 Meters |
| Exercise Therapy | One-leg Hop Test - Change in From Baseline | 13.2 Meters |
Secondary
Peak Torque Knee Extension - Change From Baseline
Change in Peak torque knee extension (Newton meter) from baseline to 12 months (higher is better).
Time frame: 1 year
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | Peak Torque Knee Extension - Change From Baseline | 8.8 Newton meter |
| Exercise Therapy | Peak Torque Knee Extension - Change From Baseline | 18.2 Newton meter |
Secondary
Peak Torque Knee Extension - Change From Baseline
Change in body weight (kilograms) normalized Peak torque knee extension (Newton meter/kg) from baseline to 10 years (higher is better).
Time frame: 10 years
Secondary
Peak Torque Knee Extension - Change From Baseline
Change in body weight (kilograms) normalized Peak torque knee extension (Newton meter/kg) from baseline to five years (higher is better).
Time frame: 5 years
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | Peak Torque Knee Extension - Change From Baseline | 0.03 Newton meters/kg |
| Exercise Therapy | Peak Torque Knee Extension - Change From Baseline | 0.13 Newton meters/kg |
Secondary
Peak Torque Knee Flexion - Change From Baseline
Change in Peak torque knee flexion (Newton meter) from baseline to 12 months (higher is better).
Time frame: 12 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | Peak Torque Knee Flexion - Change From Baseline | 4.3 Netwon meter |
| Exercise Therapy | Peak Torque Knee Flexion - Change From Baseline | 11.4 Netwon meter |
Secondary
Peak Torque Knee Flexion - Change From Baseline
Change in body weight (kilograms) normalized Peak torque knee extension (Newton meter/kg) from baseline to five years (higher is better).
Time frame: 5 years
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | Peak Torque Knee Flexion - Change From Baseline | -0.02 Newton meters/kg |
| Exercise Therapy | Peak Torque Knee Flexion - Change From Baseline | 0.04 Newton meters/kg |
Secondary
Peak Torque Knee Flexion - Change From Baseline
Change in body weight (kilograms) normalized Peak torque knee flexion (Newton meter/kg) from baseline to ten years (higher is better).
Time frame: 10 years
Secondary
SF-36 MCS - Change From Baseline
Change in Short form 36 mental component summary (SF-36 MCS) from baseline to 24 months (range: 0-100; higher is better)
Time frame: 24 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | SF-36 MCS - Change From Baseline | -0.3 units on a scale |
| Exercise Therapy | SF-36 MCS - Change From Baseline | 1.1 units on a scale |
Secondary
SF-36 PCS - Change From Baseline
Change in Short form 36 physical component summary (SF-36 PCS) from baseline to 24 months (range: 0-100; higher is better)
Time frame: 24 months
| Arm | Measure | Value (MEAN) |
|---|---|---|
| Arthroscopic Partial Meniscectomy | SF-36 PCS - Change From Baseline | 7.0 units on a scale |
| Exercise Therapy | SF-36 PCS - Change From Baseline | 5.5 units on a scale |