Chronic Rhinosinusitis
Conditions
Brief summary
The primary objective of this study is to see whether systemic corticosteroids (such as Prednisone) have an effect on the peripheral blood Treg and Th17 function in patients with CRS. Patients are taking prednisone as part of their routine medical care.
Interventions
None listed
Sponsors
University of Chicago
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosis of CRS. * A CT scan performed in the last year depicting the severity of the disease or nasal polyps on endoscopy. * Symptomatic at the time of entry into the study as determined by scores ≥ 1.4 on the Rhinosinusitis disability index
Exclusion criteria
* Women who are pregnant or breastfeeding. * Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study (heart, lung, kidney, diabetes, osteoporosis, cataracts, glaucoma, neurological, oncologic, liver disease or a contraindication to taking prednisone). * Use of any other investigational agent in the last 30 days. * Use of clinical drugs like antihistamines, leukotriene modifiers, intranasal steroids, systemic corticosteroids in the last 15 days or immunotherapy in the last year. * Upper respiratory infection within 14 days of study start * Smoking within the last 2 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treg cell numbers | pre treatment vs post treatment |
Secondary
| Measure | Time frame |
|---|---|
| Cytokine levels in cultured PBMCs | pre vs post treatment |
Countries
United States
Outcome results
None listed