Identifying Changes in Blood (Potential Biomarkers) in Individuals With Drug-Induced Liver Injury

Identification of New Biomarkers of Drug Induced Liver Injury

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01000766

Enrollment

Registered

2009-10-23

Start date

2009-09-30

Completion date

2013-12-31

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug Induced Liver Injury

Brief summary

The purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver.

Detailed description

Our hypothesis is that there are liver-specific particles, called mRNA, that are identifiable in a person's blood sample during liver injury caused by some drugs. The purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver, perhaps early in the process before significant injury or illness have occurred.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* ALT \> 200 IU/L at presentation to UNC Hospitals * Drug induced liver injury considered likely by admitting medical staff

Countries

United States

Outcome results