Carotid Atherosclerosis
Conditions
Brief summary
The build up of plaque in the wall of the artery supplying blood to the brain poses a risk of stroke when the plaques become unstable and fragile. It is important to determine which patients are most at risk so that surgery can be performed. There is evidence that the risk is greatest when these plaques become oxygen deficient (hypoxic). The investigators wish to use PET imaging to identify hypoxic plaque, to help decide whether and when to perform surgery. The investigators have developed radiotracers (imaging agents) for this purpose, and this study is to determine whether they will work in patients.
Interventions
OTHERPET-CT with CuATSM
PET-CT with CuATSM
Sponsors
Guy's and St Thomas' NHS Foundation Trust
King's College London
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male/Female patients who are 55yrs or older and for whom carotid endarterectomy is clinically indicated and a decision has been made to perform a carotid endarterectomy. * Normal liver and adequate renal function. Assessed by measuring eGFR (\>50ml/min) and creatinine (\<130μmol/L) * Life expectancy \> 12 weeks * Patients should be able to tolerate head/neck mask as well as lying in the PET-CT scanner
Exclusion criteria
* Abnormal liver and renal function (eGFR \<50ml/min, Creatinine \>130μmol/L) * Patient unwilling to provide written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uptake of CuATSM in carotid plaque | Within 30 days of carotid endarterectomy |
Secondary
| Measure | Time frame |
|---|---|
| Relationship of CuATSM uptake to plaque histology | Within 30 days of carotid endarterectomy |
Countries
United Kingdom
Outcome results
None listed