Bipolar Disorder
Conditions
Keywords
Bipolar Disorder, Bipolar Depression, Mindfulness-Based Cognitive Therapy, MBCT, Maintenance, Euthymic, Efficacy, Feasibility
Brief summary
The purpose of this study is to evaluate the feasibility and short-term efficacy of MBCT as an add-on (i.e. patients must be stable with their regular mood stabilizing medication) for the maintenance therapy of bipolar disorder.
Interventions
BEHAVIORALMindfulness-Based Cognitive Therapy
eight-week (two hours a week) group therapy (8-12 patients per group)
Sponsors
Douglas Mental Health University Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Males or females (\>18 years old) * Bipolar disorder (as per the Structured Clinical Interview for DSM Disorders (SCID)(22)), euthymic state: Complete remission for at least four weeks ((Montgomery and Asberg Rating Scale (MADRS) ≤ 6 and item-1 (depressed mood) = 0 and no suicidal ideations (MADRS(item-10) \< 4) * Must have had at least 3 depressive phases in the last 5 years * Cooperative and willing to complete all the aspects of the study and especially the 45 minutes of exercise per day * Must have completed a Secondary V (11th grade) education
Exclusion criteria
* Other active psychiatric disorders (as per the SCID) * Rapid cycling * Bipolar disorder secondary to a medical condition or substance-induced mood disorder * Suicidal ideations (MADRS(item 10)\>3) * Active i.e. unstable and/or untreated medical condition * Substance abuse (defined as per DSM-IV) in the last four weeks * CBT (No more than four sessions (ever)) * Previous participation in a psychoeducation group within the last 6 months * Current other psychotherapy (more than once a month) * Practice of meditation (more than once a month) during the last two years * Practice of yoga (more than once a week) during the last year * Previous participation in a MBSR group * Electroconvulsive Therapy (ECT) within the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of weeks in which criteria are meet for a mood episode evaluate with the Longitudinal Interval Follow-up Evaluation (LIFE) | 12 weeks (4 weeks post treatment) |
Secondary
| Measure | Time frame |
|---|---|
| Change in intensity of subsyndromal symptoms of depression on the HAM-D 29 scale | 2, 4, 6, 8 and 12 weeks |
| Change in intensity of subsyndromal symptoms of depression on the MADRS scale | 2, 4, 6, 8 and 12 weeks |
| Change in intensity of subsyndromal symptoms of hypomania on the YMRS scale | 2, 4, 6, 8 and 12 weeks |
| Change id intensity in subsyndromal symptoms of anxiety on the HAM-A scale | 2,4,6,8 and 12 weeks |
Countries
Canada
Outcome results
None listed