Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate

Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate: A Double-blind Randomized Parallel Arm Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00999297

Acronym

CAPSPAL

Enrollment

Registered

2009-10-21

Start date

2008-07-31

Completion date

2014-12-31

Last updated

2015-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Weight

Keywords

thermogenesis, respiratory quotient, fat oxidation

Brief summary

A 4 week intake of drug to find a natural substance that may modify energy balance and may enhance health in combination with lifestyle changes with possible decrease in body weight.

Detailed description

This study is a double-blind, placebo-controlled, single center, randomized, parallel arm clinical trial to test the impact of Dihydrocapsiate (placebo, 3 and 9 mg/d) ingested for 4 weeks on resting metabolic rate and fat oxidation measured by indirect calorimetry.

Interventions

OTHERDihydrocapsiate

Capsules will contain dihydrocapsiate 3 mg/d or 9 mg/d or placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Men between 20-60 years old * Healthy as assessed by medical history and standard medical exam * Weight-stable * Body mass index of 25 to 34.9 kg/m2 * Non-smoker * Sedentary lifestyle: not being physically active grater than 3 days/week for 20 min each time for the previous 6 months, and not participating in regular resistance exercise.

Exclusion criteria

* Subjects enrolled in a diet to increase or decrease body weight * Special diet or food aversiions to common foods * Has allergy to chilli pepper * Eating chilli peppers on a daily basis * Usually consuming more than 2 cups of tea or coffee/day * Usually consuming more than 4 cans of caffeinated soft drinks a day * Usually consuming more than 3 standard alcohol drinks/day * Regular use of medications (weight loss drugs, drugs affecting energy metabolism, drugs for depression) * Usual intake of illicit substances * Claustrophobia * Participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study

Design outcomes

Primary

Measure	Time frame
The consumption of dihydrocapsiate will significantly increase resting energy expenditure and fat oxidation	4 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 30, 2026