Glucose and Lipid Metabolism in Adolescents

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00998855

Enrollment

Registered

2009-10-21

Start date

2004-02-29

Completion date

2011-12-31

Last updated

2011-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise, Insulin Sensitivity, Obesity

Keywords

Exercise in obesity

Brief summary

A 12 wk aerobic exercise program will reduce visceral, hepatic and intramyocellular fat accumulation and improve insulin sensitivity and glucose metabolism in obese sedentary Hispanic adolescents.

Detailed description

Lean and Obese post pubertal adolescents perform an aerobic exercise program 30 minx4/week at a heart rate corresponding to at least 70% of that obtained at VO2 peak. The exercise program is preceded and followed by a 7 d diet delivered by the metabolic research kitchen (identical on both study occasions); metabolic studies (identical on both study occasions) including 24h calorimetry, measurements of glucose and lipid metabolism and insulin sensitivity and secretion using compounds labelled with stable i.e. non radioactive isotopes and gas chromatography-mass spectrometry.Fat mass and lean body mass are measured by DXA and visceral/subcutaneous, hepatic and intramyocellular fat by MRI/MRS. Since we want to specifically determine the effects of exercise, there is no intent of weight loss. The subjects are weighed twice a week to assure weight stability.

Interventions

BEHAVIORALExercise

12 wk aerobic or/ resistance exercise program

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

13 Years to 17 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy * No medication * Sedentary * No first degree relative with diabetes, * Hispanic * BMI \>30 or \<25 kg/m2.

Exclusion criteria

* Any medication including birth control pills * Performing more than \>45 min of moderate to light physical activity/week * Chronic illness

Design outcomes

Primary

Measure	Time frame
Fat distribution, insulin sensitivity, glucose production, gluconeogenesis, glycogenolysis	In response to a 12 wk exercise program.

Secondary

Measure	Time frame
Lipolysis, blood lipids, adiponectin, leptin and CRP	In response to a 12 wk exercise program

Countries

United States

Contacts

Primary ContactAgneta L Sunehag, M.D., Ph.D.

asunehag@bcm.tmc.edu713 798 6725

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026