Blood Loss, Coagulopathy, Rethoracotomy, Transfusion Requirements
Conditions
Keywords
modified ultrafiltration, cardiac surgery, ROTEM, Multiple Electrode Aggregometry
Brief summary
The purpose of this study is to find out, whether filtration of the blood in patients undergoing cardiac surgery, beneficially influences the coagulation system.
Detailed description
The impact of modified ultrafiltration following extracorporeal circulation on primary and secondary hemostasis is controversial. In this study we intend to assess both, primary and secondary hemostasis prior to and after the usage of modified ultrafiltration. Primary hemostasis is assessed using Multiple Electrode Aggregometry (Multiplate) and secondary hemostasis is assessed performing thrombelastometry using the ROTEM device. Patients are preoperatively randomized to receive either modified ultrafiltration or no filtration.
Interventions
DEVICEmodified ultrafiltration using Maquet haemoconcentrator, BC 20 plus
usage of modified ultrafiltration following extracorporeal circulation; filtration about 1,5 liters and re-fill with colloids
Sponsors
Goethe University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients undergoing complex cardiac surgery procedures
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ex vivo platelet aggregation (TRAPtest) | 20 min after filtration |
Secondary
| Measure | Time frame |
|---|---|
| secondary hemostasis assessed by ROTEM | 20 min before and after filtration |
| blood loss | 24 h after filtration |
| kind and number of transfused blood products | 24h after filtration |
| conventional coagulation analyses (INR, aPTT, platelet count, fibrinogen concentration) | 20 min before and after filtration |
| rate of rethoracotomy for bleeding | 24h after filtration |
Countries
Germany
Outcome results
None listed