Asthma, Obesity, Overweight
Conditions
Keywords
asthma, overweight, obesity, children
Brief summary
The purpose of this study is to determine the efficacy of a multifactorial intervention with weight reduction, behavioural therapy, and physical exercise on the severity and control of asthma in obese children.
Interventions
BEHAVIORALMultifaceted intervention
multifaceted family-based, physical exercise, nutrition, and behavioural intervention study for 18 month, in children aged 6-16 years with asthma and overweight/obesity.
Sponsors
The Netherlands Asthma Foundation
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Children aged 6-16 years * BMI in the overweight/obesity range according to data of Cole et al. * Asthma diagnosis
Exclusion criteria
* Children with a normal weight according to data of Cole et al. * Children without any provable asthmatic complaints * Congenital malformations of the airways or other chronic lung diseases like cystic fibrosis (CF) * Mental retardation or syndromes * Heart disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Forced Expiratory Volume in the first second (FEV1 %) predicted value | 2 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Symptom-free days, exacerbations | 2 years | — |
| Need for beta-2 agonists/anti-inflammatory medication | 2 years | — |
| Airway inflammation | 2 years | — |
| Levels of serum adipokines | 2 years | — |
| aerobic capacity | 2 years | VO2max measured with an maximal ergometry test |
| Weight, height, body mass index (BMI) | 2 years | — |
Countries
Netherlands
Outcome results
None listed