Contrast-enhanced Magnetic Resonance Angiography Investigation of Intracranial Aneurysms and Prospective Study of Risk Factors

Imaging Epidemiological Investigation of Intracranial Aneurysms and the Prospective Study of Risk Factors：Assessment of MR Imaging Trail

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00997698

Acronym

EIIA

Enrollment

4000

Registered

2009-10-19

Start date

2009-01-31

Completion date

2011-06-30

Last updated

2009-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intracranial Aneurysm

Keywords

Intracranial aneurysm, Magnetic resonance angiography, Epidemiology

Brief summary

This is a prospective observational registry with intent to detect the prevalence of intracranial aneurysms with contrast-enhanced MR angiography (CE-MRA) at 1.5T, and to determine the risk factors such as high blood pressure and cigarette smoking relating to intracranial aneurysms.

Detailed description

Intracranial aneurysms are common and have been reported increased incidence rate because of the widespread use of high-resolution imaging techniques. They are clinically important because of the life-threatening rupture and hemorrhage. Early detection and diagnosis is the key of treatment. Contrast-enhanced MR angiography (CE-MRA), as a simple, sensitivity and noninvasive method, is playing an important role in Vascular Imaging. CE-MRA has been an accuracy modality for intracranial aneurysm at most centers and proved the high sensitivity and accuracy comparing with DSA. Therefore, we use CE-MRA at 1.5T as a tool of epidemiological investigation of intracranial aneurysms. In retrospective analysis, conventional risk factors for intracranial aneurysms include hypertension, hyperlipidemia, diabetes mellitus (DM), smoking history, and family history, etc. However, retrospective analysis probably gives an underestimation or overestimation of the actual results. Prospective analysis will get accurate data on the risk factors relating to intracranial aneurysms

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Aged 20 to 80 years * Willing to undergo study procedures * Who are fully informed about the study and have signed the informed consent form

Exclusion criteria

* History of intracranial aneurysm * History of intracranial tumor * History of cerebral infarction * Acute stroke * Require emergency treatment * Contraindication for MRI examination * Severely impaired renal functions * Known anaphylactic reaction to MR contrast media * Pregnancy or nursing

Design outcomes

Primary

Measure	Time frame
Intracranial aneurysms identified by CE-MRA	24 months

Secondary

Measure	Time frame
Statistical analysis of the prospective factors which contribute to the development of intracranial aneurysms	6 months after the study

Countries

China

Outcome results