Prostate Cancer
Conditions
Brief summary
Study of the factors that affect interest in - and uptake of - genetic testing for variants that predispose to prostate cancer from the perspective of the patient.
Detailed description
This study will use a mixed methods approach to follow men as they move through the genetic testing process, from initial contact through to receiving their genetic testing results. A questionnaire will be used to measure variables at both baseline and after proceeding through the testing process. A small cohort of men will be invited to be interviewed to gather some in depth qualitative data about the issues that have arisen during the study process.
Interventions
None listed
Sponsors
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
40 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
* Men with a positive family history of prostate cancer. The definition of a positive family history will be: Men with a first degree relative with prostate cancer diagnosed at \<70 years; Men with two relatives with prostate cancer where at least on is diagnosed at \<70 years; Men with three relatives with prostate cancer diagnosed at any age * Age 40-69 years * No previous biopsy for raised PSA * Absence of any psychological, familial, sociological or geographic situation potentially hampering compliance with the study protocol and follow-up schedule.
Exclusion criteria
* Previous prostate cancer * Men from families where there is known to be a mutation in a high-risk prostate cancer gene * Men who have had a prostate biopsy within the last 12 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether cancer worry changes between the two time-points (measured using the Impact of Event Scale) | — |
Secondary
| Measure | Time frame |
|---|---|
| Why are men interested/ not interested in seeking genetic profiling for prostate cancer, and what might be the uptake of such testing? | — |
| What are the expectations of this testing from the perspective of the user, what are the perceived benefits and limitations of testing and how do these change through the testing process | — |
| Is there a relationship between a family history of cancer, cancer worry, and a persons intention to seek genetic testing? | — |
| How would the information provided by such a test be used by the individual and the family and how could this impact upon the healthcare system | — |
Countries
United Kingdom
Contacts
Primary ContactDr Rosalind Eeles
Backup ContactElizabeth Bancroft
Outcome results
None listed