Trial of the Ovicidal Activity of Three Head Lice Products (NeutraLice Lotion®, NeutraLice Advance® and Moov Head Lice Solution®) After a Single Application

A Randomised, Assessor Blind, Parallel Group, Comparative Trial of the Ovicidal Activity of Three Head Lice Products (NeutraLice Lotion®, NeutraLice Advance® and Moov Head Lice Solution®) After a Single Application

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00995124

Enrollment

Registered

2009-10-15

Start date

2009-10-31

Completion date

2009-12-31

Last updated

2010-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head Lice

Keywords

ovicide, head lice infestation

Brief summary

The purpose of this study is to compare the ovicidal activity of three head lice treatment products. The study population will consist of Queensland primary school-aged children (Grades 1 - 7) who have at least 20 live eggs on the hair and who have not used any head lice product in the four weeks prior to the study. Enrollment will continue to achieve 30 subjects in each treatment group (total of 90 subjects).

Detailed description

Subjects will be examined for the presence of head louse eggs. Those subjects who have at least 20 live eggs will be randomised into one of 3 treatment groups: NeutraLice Lotion, NeutraLice Advance or Moov Head Lice Solution treatment groups. Pre-treatment: 10 eggs will be removed from the head by cutting the single hair with the live egg attached, before the treatment. Treatment: The subject will then receive a single treatment application according to manufacturers instructions. Then the treatment will be washed from the hair as per the manufacturer's instructions. Post-treatment: At least 10 treated (live) eggs will be removed from the head by cutting the single hair with the egg attached, after the treatment. All of the eggs will be held in an incubator for 14 days. The proportion of eggs which hatch after 14 days will be compared for the pre-treatment and post-treatment eggs. Demographic data will be collected for each subject (hair type, hair colour, hair length, subject age, subject sex) to investigate the affect of hair type on ovicidal efficacy.

Interventions

DRUGNeutraLice Lotion

Head lice topical application to be applied once for 10 minutes.

DRUGNeutraLice Advance Solution

head lice application to be applied once for 10 minutes

DRUGMoov Head Lice Solution

Single application for head lice with 10 min application time.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

No minimum to 12 Years

Healthy volunteers

Yes

Inclusion criteria

* Male or female primary school-aged children. * Presence of at least 20 live head lice eggs on the hair. The presence of live head lice eggs will be determined from a visual inspection of the hair. * Parent / Guardian have given written informed consent to their child's participation in the trial.

Exclusion criteria

* History of allergies or adverse reactions to head lice products or the components of the specific products being tested. * Treatment with any head lice product in the 4 weeks prior to participation in this trial. * Treatment with hair dyes and bleaches within 4 weeks prior to participation in this trial. * Presence of scalp disease(s).

Design outcomes

Primary

Measure	Time frame
Ovicidal efficacy index (OEI) The proportion of treated eggs hatched in-vitro divided by the proportion of pre-treated eggs hatched in-vitro expressed as a percentage up to and including 14 days after collection and incubation.	ovicidal activity assessed after 14 days

Countries

Australia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026