Cachexia
Conditions
Brief summary
The long-term objective of this research is to develop a non-invasive approach for early assessment of which patients are at high risk for future development of skeletal muscle atrophy. The investigators hypothesize that the rate constant for the terminal portion of the isotope decay curve following ingestion of a single oral dose of deuterated-3-methylhistidine (D-3MH) provides an accurate measure of this increased risk and that this rate constant can be measured non-invasively from timed spot urine samples. In addition, the investigators hypothesize that ingestion of a meat-containing meal will stimulate synthesis of skeletal muscle proteins to a greater extent than a non-meat-containing meal.
Interventions
None listed
Sponsors
National Cancer Institute (NCI)
The University of Texas Medical Branch, Galveston
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
30 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* male * 30-85 years * Body Mass Index (BMI) \<30 kg/m2
Exclusion criteria
* Uncontrolled hypertension * Glomerular filtration rate less than 60 mL/min/1.73 m2 * History of recurrent gastrointestinal bleeding * Unable or unwilling to provide informed consent * Ongoing anti-coagulant therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of the slope of terminal D-3MH/3MH decay curve post-dosing. | Post-dosing 12 to 22 hours | Assess the slope of the terminal D-3MH/3MH decay curve for the post-dosing time period as calculated using plasma or urine samples and after a meat-containing or meat-free test meal. |
Countries
United States
Outcome results
None listed