Infertility
Conditions
Keywords
Double IUI, Intrauterine insemination, Unexplained infertility
Brief summary
Our hypothesis is double insemination will improve pregnancy rates in coh cycles with more than one dominant follicles (\>16mm).
Detailed description
Metaanalysis for the effects of double IUI demonstrates that effects of this procedure is not different from single IUI. It is known that nearly 25% of coh cycles is evident by monofollicular development.For this reason it is possible that this monofollicular cycles in the studies could decrease the effects of double IUI. Inclusion criteria: 1. Patients with unexplained infertility or mild male factor infertility whom admitted to the COH+IUI programme in our infertility unit. 2. Female age \<37 years old. 3. Baseline FSH \<12 mIU/L 4. Total antral follicle count\>6 5. During the first three cycles of COH+IUI 6. Minimum 2 follicles \>16 mm at the day of HCG. Primary outcome: Ongoing pregnancy rates Secondary outcomes: The effects of different coh regimens (CC,FSH,CC+FSH)on the outcomes.
Interventions
PROCEDUREIntrauterine insemination (single)
Single IUI after 36-38 hours of HCG
PROCEDUREDouble intrauterine insemination
Double insemination after 18 and 40 hours of HCG administration.
Sponsors
Baskent University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 37 Years
Healthy volunteers
Yes
Inclusion criteria
* Unexplained and mild male factor infertile patients * Minimum 2 follicles \>16 mm at the day of HCG * First 3 cycles
Exclusion criteria
* Basal FSH \>12 mIU/L * Total antral follicle count\<6 * Severe male factor infertility
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ongoing pregnancy rates | pregnancy >12 weeks of gestation |
Secondary
| Measure | Time frame |
|---|---|
| The effects of different coh regimens on outcomes | 14 days after IUI procedure |
Countries
Turkey (Türkiye)
Outcome results
None listed