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Does Mindfulness Training Change the Processing of Social Threat?

Does Mindfulness Training Change the Processing of Social Threat?

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00992875
Enrollment
28
Registered
2009-10-09
Start date
2009-01-31
Completion date
2011-02-28
Last updated
2012-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, Stress

Keywords

Healthy but stressed individuals

Brief summary

Training in mindfulness, the non-judgmental observation of experiences as they arise in the present moment, has been increasingly and successfully applied to the treatment of normative stress conditions and mental disorders. Yet, the neurological mechanisms that underlie the reported improvements are still largely unknown. This longitudinal study will investigate the influence of mindfulness training on a key underpinning of mental health, namely emotion regulation, and its associated brain activity. Healthy participants will be randomly assigned to either a validated eight week Mindfulness-based stress reduction (MBSR) program or to a control condition. In a pre-post investigation, participants' subjective reactions to aversive emotional stimuli (affective facial expressions) will be assessed, as will the associated brain activation using functional magnetic resonance imaging (fMRI). The investigators hypothesize that after the training the MBSR participants will rate the pictures as less aversive compared to control participants. Furthermore, the MBSR participants will show a patter of brain activation indicative of improved emotion regulation, relative to control participants. Finally, the effect of MBSR on the gray matter structure of the brain will be investigated.

Interventions

BEHAVIORALMindfulness-Based Stress Reduction

Behavioral intervention, mindfulness meditation in form of yoga, sitting meditation, body scan and mindfulness to routine activities

Sponsors

Mind and Life Institute, Hadley, Massachusetts
CollaboratorOTHER
European Commission
CollaboratorOTHER
Massachusetts General Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
22 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

* no previous significant meditation or yoga experience * eligible for MRI scanning (no metallic implants, not pregnant, not claustrophobic) * no significant previous meditation or yoga experience

Exclusion criteria

* DSM-IV diagnosis for depression, manic episodes, GAD, social phobia, anorexia, bulimia, schizophrenia, ADHD, substance dependency/abuse, suicidality * ineligible for MRI scanning (metallic implants, pregnant, claustrophobic)

Design outcomes

Primary

MeasureTime frame
BOLD signal on a 1.5T MRI scannerthe second time-point will take place eight weeks after the first data collection

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026