Ocular Physiology
Conditions
Brief summary
Adequate perfusion and oxygenation is essential for the function of the inner retina. Although this is a well known fact, measurement of oxygen saturation in the eye is still a delicate and not fully explored task. However, recently a new instrument for the non-invasive measurement of retinal vessel oxygen saturation has been introduced. Unfortunately, no data about reproducibility in humans is yet available for this instrument. Consequently, the current study seeks to evaluate the short term and day to day reproducibility of retinal vessel oxygenation in healthy volunteers. 20 healthy volunteers will be included and oxygen saturation of retinal vessels will be determined. The reproducibility of the results will be tested by repeated measurements and the collected data will be independently analyzed by two observers.
Interventions
DEVICEMeasurement of oxygen saturation of retinal vessels with optical reflectometer
5 repeated measurements on both study days
Sponsors
Medical University of Vienna
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and Women aged between 18 and 35 years, * Nonsmokers * Body mass index between 15th and 85th percentile * Normal ophthalmic findings, ametropia \< 3 Dpt.
Exclusion criteria
* Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study * Treatment in the previous 3 weeks with any drug except oral contraceptives * Symptoms of a clinically relevant illness in the 3 weeks before the study day * Blood donation during the previous 3 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coefficients of variation of oxygen measurement | 5 measurements on both study days |
Countries
Austria
Outcome results
None listed