CXCL9, CXCL10, CXCL11, and CXCR3 in Dry Eye Syndrome

Expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the Tear Film and Ocular Surface of Patients With Dry Eye Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00991679

Enrollment

Registered

2009-10-08

Start date

2008-02-29

Completion date

2008-12-31

Last updated

2009-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry Eye Syndrome

Keywords

Dry eye syndrome, CXCL9 chemokine, CXCL10 chemokine, CXCL11 chemokine, CXCR3 receptor

Brief summary

The aim of this study is to investigate the expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Thirty-three patients with dry eye (16 Sjögren's syndrome and 17 non-Sjögren's syndrome patients) and 15 control subjects were recruited. The concentrations of CXCL9, CXCL10, and CXCL11 in tears were measured using enzyme-linked immunosorbent assay. The correlation between chemokine levels and tear film and ocular surface parameters was analyzed. Expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the conjunctiva was evaluated using immunohistochemistry. Flow cytometry was performed to count CXCR3+ cells and CXCR3+CD4+ cells in the conjunctiva.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

24 Years to 77 Years

Healthy volunteers

Yes

Inclusion criteria

* clinical diagnosis of dry eye syndrome

Exclusion criteria

* active ocular infection or inflammation not associated with dry eye * drug toxicity * contact lens wear * ocular allergy * ocular surgery within the last 3 months * lid or lash abnormalities

Countries

South Korea

Outcome results