Breast Cancer, Weight Gain
Conditions
Keywords
Weight, Breast, Cancer
Brief summary
This study aims to identify and quantify the factors associated with excess weight gain following treatment for breast cancer. It is believed that breast cancer patients gain more than 4% of their weight at diagnosis which is likely accompanied by an increase in body fat and waist circumference. It is further thought that this excess weight and increase in body fat and waist circumference are associated to tumour characteristics, chemotherapy, menopause status at diagnosis and the presence of genes related to obesity. It is also thought that women treated with chemotherapy have higher levels of glucose and insulin.
Interventions
PROCEDUREFasting blood sample.
Fasting blood sample taken following informed consent for genotyping, glucose and insulin levels.
Sponsors
The Royal Bournemouth Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Females 18 years of age or older. * Diagnosed with breast cancer between 1/1/2003 and 31/12/2007. * Able to understand and willing to sign informed consent.
Exclusion criteria
* Known diagnosis of previous breast/other cancer (other than completely resected non-melanoma skin cancer or successfully treated in situ cancer of the cervix. * Known diagnosis of inflammatory bowel disease or malabsorption syndrome. * Known diagnosis of endocrine problems associated with the development of obesity (cushings syndrome, hypo/hyperthyroid, thyroiditis) * Treatment for psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To provide evidence of the relationship between weight gain following diagnosis of breast cancer and tumour characteristics, chemotherapy, menopause status at diagnosis and the presence of genes related to obesity. | 12-18 months. |
Outcome results
None listed