Collagen Analysis and Genetic Analysis of Families With Tendency to Hernias

Collagen-subtype Analysis in Subcutaneous Tissue and Genetic Analysis on Patients From Families With a Tendency to Hernias

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00991484

Enrollment

Registered

2009-10-08

Start date

2009-12-31

Completion date

2011-06-30

Last updated

2010-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hernia

Keywords

ventral, inguinal, hernia, inheritance, genetics

Brief summary

Analysis of collagen subtype subcutaneously and genetic analysis of patients from families with a tendency to hernias. Furthermore circulating biomarkers and biomarkers extracted from the subcutaneously tissue such as MMP's (matrix metallo proteinases) and TIMP's (tissue inhibitor of metallo proteinases) will be measured.

Detailed description

Research has shown relationship between hernias and collagen subtype I/III ratio, biomarkers such as MMP's TIMP's and other diseases such as Ehlers-Danlos, Marfans syndrome, AAA (abdominal aortic aneurysms), diverticulosis and rectal prolapse. Furthermore has research raised hypothesis about inheritance of hernias. The investigators are performing genetic examination combined with analysis of collagen and biomarkers on patients belonging to families with tendency to hernias. Other examinations performed on the patients enrolled in this study: * Ultrasound (US) examination of the abdominal aorta to discover possible abdominal aortic aneurysms. * Beightons score to evaluate the degree of joint hypermobility.

Interventions

None listed

Study design

Observational model

FAMILY_BASED

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* adults over 18 years * adults must be members of a family where there are presence of hernias in minimum generation.

Exclusion criteria

* infections * pregnant * mentally ill patients

Design outcomes

Primary

Measure	Time frame
Expression of collagen-genes or other relevant genes by microarray analysis compared with presence of hernia	1 year

Secondary

Measure	Time frame
Amount of collagen subtypes measured subcutaneously.	1 year

Countries

Denmark

Contacts

Primary ContactJakob Burcharth, MD

jakobburcharth@gmail.com0045 44884488

Outcome results