Study of Cytokines Serum Levels in Chronic Low Back Pain

Analytical Transversal Study of Cytokines Serum Levels in Chronic Low Back Pain Due to Herniated Disk

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00991042

Acronym

cytokine

Enrollment

Registered

2009-10-07

Start date

2003-08-31

Completion date

2005-03-31

Last updated

2009-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Interleukines

Keywords

Cytokines, Low back pain, Intervertebral disk displacement, Interleukins, Tumor necrosis factor-alpha

Brief summary

The purpose of this study is to: * evaluate if there is an association between elevated levels of cytokines and chronic pain due to herniated disk disease * measured cytokines levels in chronic low back pain and in healthy subjects.

Detailed description

23 patients with at least three months of back pain due to herniated disk disease were selected Diagnosis was confirmed by magnetic resonance imaging (MRI) or computerized tomography (CT) imaging of the spine for all patients. In addition, pain severity had to be ³ 5 points on the Numerical Rating Scale (NRS) ranging from zero (no pain) to 10 (worst imaginable pain). The exclusion criteria were defined as one or more of the following: psychiatric disorders, systemic or inflammatory disease, history of allergy, presence of motor deficits, history of blood dyscrasia, pregnancy, active infection, tumor, use of analgesic drugs in the week before or inability to come to the hospital for evaluation.

Interventions

OTHERblood collect

Five milliliters of venous blood was drawn in the morning from subjects and immediately centrifuged.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* 23 patients * least three months of back pain due to herniated disk disease * pain severity had to be 5 points on the Numerical Rating Scale (NRS) * 10 healthy volunteers: * without previous history of back pain

Exclusion criteria

* One or more of the following: * psychiatric disorders * systemic or inflammatory disease * history of allergy * presence of motor deficits * history of blood dyscrasia * pregnancy * active infection, tumor * use of analgesic drugs in the week before * inability to come to the hospital for evaluation.

Design outcomes

Primary

Measure	Time frame
cytokines levels in patients with chronic low back pain and in healthy subjects	30 days after collect

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026