Sleep
Conditions
Keywords
shift work, diabetes, Affects of shift work and sleep loss on health
Brief summary
This study aims to determine whether abnormal bodily rhythms contribute to elevate the risk of diabetes, independently of the amount of sleep loss.
Interventions
BEHAVIORALFixed restricted bedtimes
Sleep restricted to 5 hours per night for 8 nights
BEHAVIORALSleep restriction with circadian misalignment
Sleep restricted to 5 h per day for 8 days, alternating night sleep and day sleep
Sponsors
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* normal healthy men and women between the ages of 21 years and 39 years (inclusive) with normal weight (i.e., body mass index under 28 kg/m2 in men, 27 kg/m2 in women) * normal findings on clinical examination, normal results on routine laboratory tests, normal EKG, normal glucose tolerance test, negative pregnancy test for women * no personal history of psychiatric or endocrine illness * no personal history of sleep disorder, usual total sleep time of at least 7 hours * only female volunteers with normal ovulatory cycles will be included
Exclusion criteria
* subjects with irregular life habits (shiftworkers and subjects having traveled across time zones less than one month prior to the beginning of the baseline study) * subjects taking any medication (including hormonal contraceptive therapy), and smokers are excluded * subjects with significant sleep apnea (apnea index above 10) or significant arousal-associated periodic leg movements are excluded
Countries
United States
Outcome results
None listed