Indole-3-Carbinol Effects on Estrogen Metabolism

Effects of Dietary Indole-3-Carbinol on Estrogen Metabolites Across a Wide Range of Body Mass Index: Implications for the Prevention of Endometrial Cancer in Obese Women

Status

Terminated

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00988845

Enrollment

Registered

2009-10-02

Start date

2009-09-30

Completion date

2014-01-31

Last updated

2019-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

dietary supplement, indole 3 carbinol, estrogen

Brief summary

This study will test a dietary supplement, indole-3-carbinol, for improving the estrogen profile in women across a range of body mass index.

Interventions

DIETARY_SUPPLEMENTIndole-3-carbinol

200 mg bid po X 8 weeks

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

30 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* woman aged from 30 - 50 years * regular menstrual cycle

Exclusion criteria

* taking hormone replacement or hormonal contraception * thyroid disorder * uncontrolled asthma * BMI under 18.5 * allergy to cruciferous vegetables

Design outcomes

Primary

Measure	Time frame
Change in urinary 2/16-hydroxyestrone ratio	8 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026