Basal Cell Carcinoma
Conditions
Keywords
basal cell carcinoma, photodynamic therapy, photo chemotherapy, basal cell epithelioma
Brief summary
The purpose of this study is to evaluate the efficacy of photodynamic therapy (PDT)in treatment of Basal cell carcinoma (BCC) and recurrence rate after 6 months.
Detailed description
Background and Aim: Basal cell carcinoma (BCC) is the most common skin cancer .Photodynamic therapy \_as a novel , non-invasive therapeutic approach \_may be considered a valuable strategy. This study was designed with the aim of the evaluation of efficacy of PDT in treatment of BCC and recurrence rate after 6 months . Materials and Methods: This was a clinical trial which was done on 28 BCCs. Patients were treated with ALA-PDT monthly for 1-6 sessions and evaluated for clinical response,cosmetic results,recurrence rate and probable side effects.
Interventions
RADIATIONphotodynamic therapy
5-ALA cream 20% topical administration + photodynamic therapy (red light) 120 j/cm2
Sponsors
Shahid Beheshti University of Medical Sciences
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Histologically proven BCCs
Exclusion criteria
* Rodent ulcer * Morphea type * ANA + * History of photosensitivity or photodermatosis or ingestion of phototoxic drugs during last month * Pregnancy * Breast feeding * Age\< 18 * History of another therapeutic intervention for bcc during last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| response rate at the end of therapy protocol (regarding tumor diameter and/or pathologic examination) | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| recurrence rate(regarding clinical and/or pathological examination) after 6 months of follow up | 1 year |
Outcome results
None listed