Mild to Moderate Acne
Conditions
Brief summary
This is a clinical trial to compare the benefits and possible adverse events of two antibiotic treatments for mild to moderate acne. It is expected that minocycline microgranules will be more effective than lymecycline with a better adverse events profile.
Interventions
DRUGMinocycline vs Lymecycline
Minocycline 100 mg OD per mouth for 8 weeks. Lymecycline 300 mg OD per mouth for 8 weeks.
Sponsors
Darier
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
14 Years to 30 Years
Healthy volunteers
No
Inclusion criteria
* Both gender * 14 to 30 years old * Mild to moderate acne * Face localization * At least 20 non-inflammatory lesions OR * At least 15 inflammatory lesions OR * At least 30 total lesions AND * Less than 5 nodular lesions
Exclusion criteria
* Patients younger than 14 or older than 30 years old * Less than 20 non-inflammatory lesions OR * Less than 15 inflammatory lesions OR * Less than 30 total lesions * Patients with severe acne * More than 5 nodular lesions OR * More than 50 inflammatory lesions OR * More than 125 total lesions * Pregnant women * Lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of inflammatory and non-inflammatory acne lesions | 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of local and systemic adverse events | 8 weeks |
Countries
Mexico
Contacts
Primary ContactLuis Leobardo Velázquez-Arenas, MD
Backup ContactJorge Ocampo-Candiani, MD
Outcome results
None listed