Non-Contact Measurement of Aortic Compliance

Non Contact Measurement of Aortic Pulse Wave Velocity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00987181

Enrollment

Registered

2009-09-30

Start date

2010-09-30

Completion date

2013-03-31

Last updated

2015-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vascular Disease

Keywords

Pulse wave velocity, Non contact, Non-invasive, Photoplethysmography, Doppler flow velocimetry

Brief summary

Reduced aortic stiffness is a powerful way to predict the outcome of cardiovascular (CV) disease. There are several non invasive methods for its estimation, most of which are based on the measurement of speed of the arterial pulse wave. (The stiffer the artery, the faster the pulse wave travels.) They rely on detecting the arterial pulse with 2 sensors placed on the skin a known distance apart and measuring the time for the pulse to travel between them. However all current methods require skilled operators and are of limited accuracy. Thus, there is a need for an easy to use and reliable device to measure pulse speed. The aim of this project is to develop a non contact device to detect the aortic pulse as it moves into the small arteries following the ribs, using the principle of thermal imaging, by means of a high sensitivity infra red camera, directed towards the subjects back. The investigators plan to validate the device and conduct a small feasibility study in patients undergoing elective angiography, by simultaneously measuring pulse speed using established methods. These are Doppler ultrasound (non-invasive) and direct intra-arterial measurement (the gold standard).

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18 years and above * Patients eligible for coronary angiography * Informed consent obtained * Able to complete experimental protocol

Exclusion criteria

* Refusal of consent * Age below 18 years * Breast feeding * Known or suspected pregnancy * Patient participating in another study at time of study entry or previous participation in this registry * diagnosed but untreated hypertension

Design outcomes

Primary

Measure	Time frame
Quantitative agreement between intra-arterial measurement of aortic pulse wave velocity and transcutaneous values: a) Contact PPG from probes on the skin of the back in the intercostal spaces and b) non-contact from infra-red camera imaging the back.	Single measurement to be made between January 2010 and June 2010

Secondary

Measure	Time frame
Assessment of differences in aPWV and between low and high risk groups of patients undergoing elective coronary angiography.	Single measurement to be made between January 2010 and June 2010

Countries

United Kingdom

Outcome results