S8516-S8736-S9125-S9240 Research Study of Genes in Tissue Samples From Patients With B-cell Non-Hodgkin Lymphoma

Pharmacogenomics of Oxidative Stress-Related Genes in Lymphoma

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00985699

Enrollment

337

Registered

2009-09-28

Start date

2009-04-30

Completion date

2014-06-30

Last updated

2014-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lymphoma

Keywords

non-Hodgkin lymphoma, cutaneous B-cell non-Hodgkin lymphoma, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, nodal marginal zone B-cell lymphoma

Brief summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at genes in tissue samples from patients with B-cell non-Hodgkin lymphoma.

Detailed description

OBJECTIVES: * To determine if toxicity following treatment for lymphoma varies according to genetic polymorphisms in oxidative stress-related genes (i.e., SOD2, CAT, GPX1, GSTM1, and GSTP1). * To assess whether these genetic polymorphisms are associated with progression-free survival and/or overall survival in these patients treated for lymphoma. OUTLINE: Previously collected samples are used for biomarker analysis.

Interventions

GENETICpolymorphism analysis

OTHERlaboratory biomarker analysis

OTHERpharmacogenomic studies

Study design

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Diagnosis of aggressive B-cell non-Hodgkin lymphoma * Previously treated with curative intent using anthracycline-based therapies * Previously collected paraffin-embedded diagnostic tissues from clinical trials that were collected as part of SWOG treatment protocols (S8516, S8736, S9125, S9240, and S9349) available PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * See Disease Characteristics

Design outcomes

Primary

Measure	Time frame
Association of polymorphisms in oxidative stress-related genes with overall survival and/or progression-free survival	retrospectively
Association of polymorphisms in these genes with rate of grade 4-5 hematologic toxicity	retrospectively

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026