TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00985049

Enrollment

350

Registered

2009-09-28

Start date

2009-03-31

Completion date

2025-12-31

Last updated

2024-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases

Brief summary

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Aged greater than 20 years * Undergoing aortic valve surgery with or without CABG surgery * Receive and apical vent as part of the surgery

Exclusion criteria

* Will not receive an apical left ventricular vent

Design outcomes

Primary

Measure	Time frame
Differential gene expression	Immediate

Countries

United States

Contacts

Primary ContactJochen D Muehlschlegel, MD, MMSc, MBA

dmuehlsch@jhu.edu4109558408

Outcome results